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Change in γH2AX in patient peripheral blood blasts at 2 h following vosaroxin treatment in the weekly schedule on days 1 and 8 (50 mg/m2, n=1; 60 mg/m2, n=2; 72 mg/m2, n=5; 90 mg/m2, n=2) at one study center. Responders (filled symbols: 50 mg/m2, n=1; 60 mg/m2, n=1; 72 mg/m2, n=1; 90 mg/m2, n=2) had bone marrow blasts <5% after treatment and non-responders (open symbols: 60 mg/m2, n=1; 72 mg/m2, n=4) had bone marrow blasts ≥5% after treatment.
