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. 1993 Feb 1;90(3):873–877. doi: 10.1073/pnas.90.3.873

Dissociation of human mid-dorsolateral from posterior dorsolateral frontal cortex in memory processing.

M Petrides 1, B Alivisatos 1, A C Evans 1, E Meyer 1
PMCID: PMC45772  PMID: 8430100

Abstract

Work with non-human primates had previously demonstrated that the mid-dorsolateral frontal cortex, which comprises cytoarchitectonic areas 46 and 9, plays a critical role in the performance of non-spatial self-ordered working memory tasks, whereas the immediately adjacent posterior dorsolateral frontal cortex (area 8) is critical for the learning and performance of visual conditional associative tasks. The present study used positron emission tomography with magnetic resonance imaging to demonstrate the existence, within the human brain, of these two functionally distinct subdivisions of the lateral frontal cortex. These findings provide direct evidence that, just as the monkey brain, the human lateral frontal cortex is functionally heterogeneous and that comparable anatomical areas underlie similar functions in the two species.

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Selected References

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  1. Bruce C. J., Goldberg M. E. Primate frontal eye fields. I. Single neurons discharging before saccades. J Neurophysiol. 1985 Mar;53(3):603–635. doi: 10.1152/jn.1985.53.3.603. [DOI] [PubMed] [Google Scholar]
  2. Evans A. C., Marrett S., Neelin P., Collins L., Worsley K., Dai W., Milot S., Meyer E., Bub D. Anatomical mapping of functional activation in stereotactic coordinate space. Neuroimage. 1992 Aug;1(1):43–53. doi: 10.1016/1053-8119(92)90006-9. [DOI] [PubMed] [Google Scholar]
  3. Evans A. C., Marrett S., Torrescorzo J., Ku S., Collins L. MRI-PET correlation in three dimensions using a volume-of-interest (VOI) atlas. J Cereb Blood Flow Metab. 1991 Mar;11(2):A69–A78. doi: 10.1038/jcbfm.1991.40. [DOI] [PubMed] [Google Scholar]
  4. Fox P. T., Fox J. M., Raichle M. E., Burde R. M. The role of cerebral cortex in the generation of voluntary saccades: a positron emission tomographic study. J Neurophysiol. 1985 Aug;54(2):348–369. doi: 10.1152/jn.1985.54.2.348. [DOI] [PubMed] [Google Scholar]
  5. Fox P. T., Mintun M. A., Reiman E. M., Raichle M. E. Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of subtracted PET images. J Cereb Blood Flow Metab. 1988 Oct;8(5):642–653. doi: 10.1038/jcbfm.1988.111. [DOI] [PubMed] [Google Scholar]
  6. Fox P. T., Perlmutter J. S., Raichle M. E. A stereotactic method of anatomical localization for positron emission tomography. J Comput Assist Tomogr. 1985 Jan-Feb;9(1):141–153. doi: 10.1097/00004728-198501000-00025. [DOI] [PubMed] [Google Scholar]
  7. Halsband U., Passingham R. The role of premotor and parietal cortex in the direction of action. Brain Res. 1982 May 27;240(2):368–372. doi: 10.1016/0006-8993(82)90239-6. [DOI] [PubMed] [Google Scholar]
  8. Haxby J. V., Grady C. L., Horwitz B., Ungerleider L. G., Mishkin M., Carson R. E., Herscovitch P., Schapiro M. B., Rapoport S. I. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1621–1625. doi: 10.1073/pnas.88.5.1621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Milner B. Interhemispheric differences in the localization of psychological processes in man. Br Med Bull. 1971 Sep;27(3):272–277. doi: 10.1093/oxfordjournals.bmb.a070866. [DOI] [PubMed] [Google Scholar]
  10. Pardo J. V., Pardo P. J., Janer K. W., Raichle M. E. The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. Proc Natl Acad Sci U S A. 1990 Jan;87(1):256–259. doi: 10.1073/pnas.87.1.256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Petrides M. Deficits in non-spatial conditional associative learning after periarcuate lesions in the monkey. Behav Brain Res. 1985 Aug;16(2-3):95–101. doi: 10.1016/0166-4328(85)90085-3. [DOI] [PubMed] [Google Scholar]
  12. Petrides M. Deficits on conditional associative-learning tasks after frontal- and temporal-lobe lesions in man. Neuropsychologia. 1985;23(5):601–614. doi: 10.1016/0028-3932(85)90062-4. [DOI] [PubMed] [Google Scholar]
  13. Petrides M., Milner B. Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man. Neuropsychologia. 1982;20(3):249–262. doi: 10.1016/0028-3932(82)90100-2. [DOI] [PubMed] [Google Scholar]
  14. Petrides M. Monitoring of selections of visual stimuli and the primate frontal cortex. Proc Biol Sci. 1991 Dec 23;246(1317):293–298. doi: 10.1098/rspb.1991.0157. [DOI] [PubMed] [Google Scholar]
  15. Petrides M. Motor conditional associative-learning after selective prefrontal lesions in the monkey. Behav Brain Res. 1982 Aug;5(4):407–413. doi: 10.1016/0166-4328(82)90044-4. [DOI] [PubMed] [Google Scholar]
  16. Petrides M. Nonspatial conditional learning impaired in patients with unilateral frontal but not unilateral temporal lobe excisions. Neuropsychologia. 1990;28(2):137–149. doi: 10.1016/0028-3932(90)90096-7. [DOI] [PubMed] [Google Scholar]
  17. Raichle M. E., Martin W. R., Herscovitch P., Mintun M. A., Markham J. Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation. J Nucl Med. 1983 Sep;24(9):790–798. [PubMed] [Google Scholar]
  18. Roland P. E., Skinhøj E., Lassen N. A., Larsen B. Different cortical areas in man in organization of voluntary movements in extrapersonal space. J Neurophysiol. 1980 Jan;43(1):137–150. doi: 10.1152/jn.1980.43.1.137. [DOI] [PubMed] [Google Scholar]
  19. Schall J. D. Neuronal activity related to visually guided saccadic eye movements in the supplementary motor area of rhesus monkeys. J Neurophysiol. 1991 Aug;66(2):530–558. doi: 10.1152/jn.1991.66.2.530. [DOI] [PubMed] [Google Scholar]
  20. Stanton G. B., Deng S. Y., Goldberg M. E., McMullen N. T. Cytoarchitectural characteristic of the frontal eye fields in macaque monkeys. J Comp Neurol. 1989 Apr 15;282(3):415–427. doi: 10.1002/cne.902820308. [DOI] [PubMed] [Google Scholar]
  21. Worsley K. J., Evans A. C., Marrett S., Neelin P. A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab. 1992 Nov;12(6):900–918. doi: 10.1038/jcbfm.1992.127. [DOI] [PubMed] [Google Scholar]

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