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Autophagy is induced with both starvation and pancreatitis, but the autophagic flux is retarded in pancreatitis due to inefficient lysosomal degradation resulting from impaired cathepsin processing/maturation. The illustration depicts a pancreatic acinar cell; open and closed scissors represent, respectively, normal or deficient cathepsin activity. AL, autolysosome; AP, autophagosome; L, lysosome; N, nucleus; PG, phagophore; ZG, zymogen granule.
