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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Ophthalmology. 2015 Jul 30;122(10):1987–2001. doi: 10.1016/j.ophtha.2015.06.041

Table 4.

Incidence of IOP* elevation (IOP* ≥ 21, 30, 10mmHg rise) in pediatric eyes with non-infectious uveitis over 2 years: Absolute risk, relative hazard and risk factors

IOP*≥21mmHg IOP*≥ 30mmHg IOP*≥10mmHg rise
Variable Univariate Multivariate* Univariate Multivariate* Univariate Multivariate*
2-year
Incidence
Estimate (95%
CI*)		 Hazard Ratio
(95% CI*)		 P* Hazard Ratio
(95% CI)		 P* 2-year
Incidence
Estimate
(95% CI*)		 Hazard Ratio
(95% CI*)		 P* Hazard Ratio
(95% CI)		 P* 2-year
Incidence
Estimate
(95% CI*)		 Hazard Ratio
(95% CI*)		 P* Hazard Ratio
(95% CI)		 P*
Age at presentation <6 years 0.39 (0.21, 0.54) 1.19 (0.67, 2.12) 0.57 1.23 (0.69, 2.18) 0.74 0.16 (0.02, 0.29) 1.11 (0.45, 2.77) 0.93 1.20 (0.48, 3.01) 0.92 0.29 (0.10, 0.43) 1.22 (0.60, 2.49) 0.82 1.32 (0.60, 2.90) 0.78
6–12 years 0.34 (0.27, 0.41) 1 1 0.15 (0.10, 0.20) 1 1 0.24 (0.18, 0.30) 1 1
13–17 years 0.31 (0.23, 0.38) 0.88 (0.61, 1.27) 0.95 (0.64, 1.42) 0.14 (0.08, 0.19) 0.94 (0.56, 1.58) 1.0003 (0.57, 1.77) 0.24 (0.17, 0.30) 0.96 (0.65, 1.43) 1.01 (0.65, 1.56)
Sex Male 0.35 (0.27, 0.42) 1 0.62 1 0.54 0.13 (0.08, 0.18) 1 0.33 1 0.40 0.25 (0.19, 0.31) 1 0.70 1 0.58
Female 0.32 (0.26, 0.39) 0.92 (0.65, 1.30) 0.89 (0.62, 1.28) 0.16 (0.11, 0.21) 1.28 (0.78, 2.11) 1.26 (0.74, 2.14) 0.24 (0.18, 0.29) 0.93 (0.64, 1.35) 0.89 (0.58, 1.35)
Race category White 0.31 (0.25, 0.37) 1 0.39 1 0.98 0.13 (0.09, 0.17) 1 0.27 1 0.78 0.23 (0.18, 0.27) 1 0.06 1 0.69
Black 0.41 (0.21, 0.56) 1.39 (0.78, 2.49) 0.97 (0.55, 1.71) 0.26 (0.07, 0.42) 2.13 (0.96, 4.71) 1.59 (0.59, 4.28) 0.40 (0.22, 0.53) 1.97 (1.16, 3.35) 1.12 (0.53, 2.36)
Hispanic 0.45 (0.20, 0.62) 1.58 (0.83, 3.01) 1.14 (0.60, 2.18) 0.19 (0.04, 0.32) 1.47 (0.61, 3.51) 1.21 (0.49, 3.01) 0.33 (0.13, 0.48) 1.54 (0.78, 3.01) 1.52 (0.74, 3.11)
Other 0.36 (0.16, 0.52) 1.20 (0.63, 2.28) 1.01 (0.53, 1.90) 0.14 (0, 0.27) 1.07 (0.35, 3.25) 1.27 (0.42, 3.81) 0.20 (0.03, 0.34) 0.86 (0.35, 2.11) 0.93 (0.38, 2.31)
Juvenile idiopathic arthritis No 0.33 (0.27, 0.39) 1 0.80 1 0.59 0.14 (0.10, 0.19) 1 0.62 1 0.11 0.24 (0.19, 0.29) 1 0.76 1 0.13
Yes 0.34 (0.25, 0.43) 1.05 (0.73, 1.50) 0.87 (0.53, 1.44) 0.16 (0.09, 0.23) 1.14 (0.68, 1.91) 0.57 (0.29, 1.14) 0.25 (0.17, 0.33) 1.07 (0.71, 1.59) 0.67 (0.39, 1.13)
Sarcoidosis No 0.34 (0.28, 0.39) 1 0.66 1 0.13 0.15 (0.11, 0.19) 1 n/a 1 n/a 0.25 (0.20, 0.29) 1 0.29 1 0.09
Yes 0.27 (0, 0.49) 0.78 (0.26, 2.36) 0.54 (0.25, 1.19) 0 (n/a) 0 (n/a) 0 (n/a) 0.15 (0, 0.28) 0.57 (0.20, 1.62) 0.40 (0.13, 1.17)
HLA-B27 No 0.34 (0.28, 0.39) 1 0.13 1 0.03 0.15 (0.11, 0.19) 1 0.42 1 0.07 0.25 (0.20, 0.29) 1 0.21 1 0.02
Yes 0.21 (0.06, 0.34) 0.57 (0.27, 1.18) 0.35 (0.13, 0.91) 0.10 (0.002, 0.19) 0.66 (0.24, 1.82) 0.38 (0.13, 1.09) 0.16 (0.04, 0.26) 0.61 (0.28, 1.32) 0.35 (0.15, 0.85)
Adamantiades-Behçet’s disease No 0.34 (0.28, 0.39) 1 0.47 1 0.24 0.15 (0.11, 0.19) 1 0.92 1 0.03 0.24 (0.20, 0.29) 1 0.72 1 0.83
Yes 0.17 (0, 0.44) 0.46 (0.06, 3.75) 0.45 (0.12, 1.71) 0.16 (0, 0.42) 1.11 (0.13, 9.30) 4.75 (1.15, 19.6) 0.17 (0, 0.44) 0.67 (0.08, 5.61) 1.15 (0.32, 4.16)
Hypertension No 0.34 (0.28, 0.39) 1 0.17 1 0.12 0.15 (0.11, 0.19) 1 0.46 1 0.10 0.25 (0.20, 0.29) 1 0.53 1 0.11
Yes 0.10 (0, 0.26) 0.25 (0.03, 1.78) 0.21 (0.03, 1.49) 0.07 (0, 0.20) 0.48 (0.07, 3.41) 0.19 (0.02, 1.41) 0.17 (0, 0.35) 0.64 (0.16, 2.53) 0.41 (0.14, 1.23)
Cataract surgery Never 0.32 (0.27, 0.37) 1 0.03 1 0.54 0.14 (0.10, 0.18) 1 0.051 1 0.87 0.23 (0.18, 0.27) 1 0.005 1 0.85
Prior to SITE 0.35 (0.07, 0.54) 1.09 (0.47, 2.51) 0.59 (0.18, 1.90) 0.32 (0.05, 0.52) 2.63 (1.07, 6.48) 1.19 (0.36, 3.95) 0.42 (0.22, 0.57) 2.14 (1.20, 3.82) 0.79 (0.28, 2.17)
During SITE 0.59 (0.31, 0.75) 2.27 (1.23, 4.19) 0.67 (0.28, 1.59) 0.26 (0.06, 0.42) 2.06 (0.91, 4.65) 0.85 (0.30, 2.42) 0.46 (0.19, 0.64) 2.37 (1.21, 4.66) 1.05 (0.39, 2.81)
Pars plana vitrectomy (not retinal detachment) No 0.32 (0.26, 0.37) 1 <0.001 1 <0.001 0.14 (0.10, 0.18) 1 0.15 1 0.52 0.23 (0.19, 0.28) 1 0.01 1 0.20
Yes 0.68 (0.42, 0.82) 2.98 (1.74, 5.11) 3.36 (1.75, 6.45) 0.24 (0.07, 0.37) 1.74 (0.81, 3.72) 1.40 (0.50, 3.93) 0.45 (0.21, 0.62) 2.24 (1.20, 4.19) 1.72 (0.75, 3.93)
Retinal detachment surgery No 0.34 (0.28, 0.39) 1 n/a 1 n/a 0.15 (0.11, 0.19) 1 0.93 1 0.42 0.24 (0.20, 0.29) 1 0.98 1 0.60
Yes 0 (n/a) 0 (n/a) 0 (n/a) 0.14 (0, 0.37) 0.91 (0.10, 8.10) 2.92 (0.22, 39.2) 0.25 (0, 0.55) 1.03 (0.18, 5.87) 1.71 (0.23, 13.0)
Uveitis category Anterior 0.36 (0.28, 0.43) 1 0.06 1 0.92 0.16 (0.10, 0.22) 1 0.84 1 0.33 0.27 (0.20, 0.34) 1 0.30 1 0.41
Intermediate 0.28 (0.20, 0.35) 0.75 (0.51, 1.10) 0.98 (0.60, 1.62) 0.14 (0.08, 0.19) 0.86 (0.50, 1.46) 1.09 (0.58, 2.06) 0.22 (0.15, 0.28) 0.76 (0.50, 1.16) 0.93 (0.55, 1.57)
Posterior 0.25 (0.06, 0.40) 0.64 (0.28, 1.47) 0.84 (0.36, 1.96) 0.10 (0, 0.20) 0.62 (0.20, 1.91) 1.15 (0.35, 3.81) 0.15 (0.03, 0.26) 0.51 (0.21, 1.24) 0.60 (0.23, 1.53)
Panuveitis 0.48 (0.30, 0.61) 1.48 (0.90, 2.43) 1.15 (0.63, 2.09) 0.14 (0.03, 0.24) 0.88 (0.37, 2.08) 0.35 (0.11, 1.12) 0.29 (0.15, 0.40) 1.05 (0.59, 1.90) 0.58 (0.27, 1.25)
Bilateral uveitis No 0.48 (0.33, 0.60) 1 0.01 1 0.29 0.16 (0.06, 0.25) 1 0.73 1 0.59 0.35 (0.21, 0.47) 1 0.049 1 0.84
Yes 0.32 (0.26, 0.37) 0.59 (0.39, 0.90) 0.76 (0.45, 1.27) 0.15 (0.10, 0.19) 0.89 (0.45, 1.75) 1.26 (0.54, 2.94) 0.23 (0.18, 0.28) 0.61 (0.38, 0.998) 0.94 (0.51, 1.73)
Duration of uveitis prior to presentation <6 Months 0.39 (0.31, 0.47) 1 0.14 1 0.01 0.15 (0.09, 0.20) 1 0.83 1 0.81 0.27 (0.20, 0.33) 1 0.48 1 0.65
6 Months to <2 Years 0.30 (0.22, 0.38) 0.72 (0.49, 1.07) 0.63 (0.43, 0.94) 0.16 (0.09, 0.22) 1.08 (0.62, 1.89) 1.11 (0.64, 1.92) 0.22 (0.15, 0.29) 0.80 (0.52, 1.25) 0.82 (0.51, 1.32)
2 to <5 Years 0.25 (0.12, 0.36) 0.57 (0.31, 1.04) 0.48 (0.24, 0.97) 0.12 (0.03, 0.20) 0.80 (0.35, 1.81) 0.65 (0.23, 1.80) 0.18 (0.08, 0.28) 0.65 (0.33, 1.25) 0.66 (0.30, 1.46)
5+ Years 0.28 (0.14, 0.40) 0.65 (0.36, 1.17) 0.52 (0.26, 1.01) 0.18 (0.05, 0.28) 1.25 (0.57, 2.70) 0.85 (0.31, 2.35) 0.28 (0.14, 0.39) 1.04 (0.59, 1.86) 0.79 (0.39, 1.59)
Other eye history of IOP* elevation Normal 0.30 (0.24, 0.35) 1 <0.001 1 <0.001 0.10 (0.07, 0.14) 1 <0.001 1 <0.001 0.22 (0.17, 0.27) 1 0.009 1 0.03
21 – <30 0.60 (0.45, 0.72) 2.63 (1.76, 3.92) 2.85 (1.88, 4.31) 0.27 (0.16, 0.36) 2.92 (1.72, 4.96) 3.36 (2.00, 5.63) 0.31 (0.19, 0.40) 1.46 (0.93, 2.30) 1.74 (1.11, 2.75)
≥30 0.64 (0, 0.91) 2.92 (0.78, 11.0) 2.46 (0.57, 10.6) 0.58 (0, 0.88) 8.04 (1.91, 33.8) 9.54 (1.95, 46.7) 0.57 (0.06, 0.81) 3.42 (1.35, 8.65) 2.34 (0.60, 9.07)
Drops/Surgery 0.43 (0.20, 0.59) 1.59 (0.86, 2.92) 1.83 (0.88, 3.81) 0.39 (0.18, 0.54) 4.55 (2.41, 8.58) 6.22 (2.69, 14.4) 0.37 (0.19, 0.52) 1.88 (1.04, 3.43) 2.22 (1.09, 4.55)
History of hypotony* No 0.33 (0.28, 0.39) 1 0.75 1 0.07 0.15 (0.11, 0.19) 1 0.40 1 0.09 0.24 (0.20, 0.29) 1 0.52 1 0.35
Yes 0.29 (0, 0.50) 0.85 (0.30, 2.41) 0.40 (0.15, 1.07) 0.06 (0, 0.18) 0.41 (0.05, 3.21) 0.13 (0.01, 1.38) 0.31 (0.05, 0.50) 1.34 (0.55, 3.22) 0.66 (0.28, 1.57)
Other eye history of hypotony* No 0.34 (0.28, 0.39) 1 0.70 1 0.06 0.15 (0.11, 0.19) 1 0.90 1 0.15 0.24 (0.20, 0.29) 1 0.17 1 0.30
Yes 0.29 (0.05, 0.48) 0.85 (0.36, 2.00) 0.39 (0.15, 1.04) 0.14 (0, 0.30) 0.92 (0.23, 3.66) 0.28 (0.05, 1.60) 0.37 (0.12, 0.55) 1.65 (0.81, 3.37) 0.66 (0.30, 1.44)
Visual acuity 20/40 or better 0.30 (0.23, 0.36) 1 0.02 1 0.13 0.11 (0.07, 0.15) 1 0.004 1 0.12 0.19 (0.14, 0.24) 1 0.003 1 0.27
>20/40 – <20/200 0.44 (0.33, 0.52) 1.62 (1.13, 2.32) 1.35 (0.90, 2.03) 0.23 (0.14, 0.31) 2.34 (1.40, 3.91) 1.89 (1.03, 3.47) 0.32 (0.23, 0.40) 1.81 (1.21, 2.71) 1.45 (0.89, 2.34)
20/200 or worse 0.31 (0.16, 0.42) 1.03 (0.59, 1.78) 0.81 (0.42, 1.55) 0.20 (0.08, 0.30) 1.94 (0.98, 3.82) 1.52 (0.60, 3.84) 0.35 (0.21, 0.47) 2.02 (1.22, 3.34) 1.54 (0.80, 2.94)
Inflammatory activity Inactive 0.36 (0.28, 0.43) 1 0.59 1 0.34 0.16 (0.10, 0.22) 1 0.22 1 0.83 0.26 (0.20, 0.32) 1 0.15 1 0.66
Slightly active 0.33 (0.20, 0.44) 0.90 (0.56, 1.46) 1.13 (0.66, 1.92) 0.20 (0.09, 0.30) 1.26 (0.66, 2.40) 1.03 (0.48, 2.23) 0.31 (0.19, 0.42) 1.22 (0.75, 1.97) 1.26 (0.70, 2.26)
Active 0.31 (0.23, 0.38) 0.83 (0.58, 1.18) 1.42 (0.89, 2.27) 0.11 (0.06, 0.16) 0.69 (0.39, 1.21) 0.80 (0.35, 1.84) 0.20 (0.14, 0.26) 0.73 (0.47, 1.13) 0.97 (0.51, 1.86)
Anterior chamber cells Quiet 0.35 (0.27, 0.41) 1 0.01 1 <0.001 0.15 (0.10, 0.20) 1 0.01 1 0.005 0.24 (0.18, 0.30) 1 0.01 1 0.004
0.5+ 0.43 (0.32, 0.52) 1.32 (0.90, 1.93) 0.88 (0.61, 1.27) 0.23 (0.14, 0.31) 1.59 (0.95, 2.66) 1.23 (0.73, 2.09) 0.34 (0.24, 0.43) 1.51 (1.005, 2.28) 1.08 (0.71, 1.64)
1+ 0.28 (0.16, 0.39) 0.78 (0.47, 1.31) 0.46 (0.26, 0.81) 0.11 (0.04, 0.18) 0.73 (0.36, 1.48) 0.40 (0.18, 0.87) 0.20 (0.11, 0.29) 0.83 (0.47, 1.48) 0.50 (0.27, 0.94)
2+ or worse 0.20 (0.10, 0.29) 0.53 (0.31, 0.93) 0.30 (0.17, 0.52) 0.06 (0.004, 0.10) 0.35 (0.14, 0.92) 0.19 (0.06, 0.61) 0.15 (0.06, 0.22) 0.58 (0.31, 1.08) 0.36 (0.19, 0.68)
Vitreous cells Quiet 0.36 (0.29, 0.42) 1 0.24 1 0.43 0.16 (0.11, 0.22) 1 0.11 1 0.07 0.26 (0.20, 0.32) 1 0.29 1 0.25
0.5+ 0.26 (0.14, 0.36) 0.68 (0.41, 1.13) 0.70 (0.40, 1.25) 0.06 (0.009, 0.11) 0.34 (0.14, 0.80) 0.26 (0.10, 0.73) 0.16 (0.07, 0.24) 0.55 (0.30, 1.01) 0.49 (0.23, 1.03)
1+ 0.37 (0.23, 0.48) 1.03 (0.64, 1.65) 1.16 (0.70, 1.91) 0.15 (0.06, 0.23) 0.88 (0.43, 1.78) 0.82 (0.38, 1.79) 0.24 (0.14, 0.33) 0.88 (0.52, 1.48) 0.80 (0.43, 1.48)
2+ or worse 0.25 (0.12, 0.36) 0.65 (0.37, 1.14) 0.94 (0.51, 1.73) 0.15 (0.05, 0.23) 0.89 (0.44, 1.83) 0.93 (0.40, 2.16) 0.23 (0.13, 0.32) 0.86 (0.50, 1.48) 0.96 (0.50, 1.86)
Vitreous haze Quiet 0.35 (0.29, 0.40) 1 0.73 1 0.52 0.15 (0.10, 0.19) 1 0.98 1 0.93 0.24 (0.19, 0.29) 1 0.91 1 0.80
1+ 0.29 (0.12, 0.43) 0.81 (0.42, 1.56) 0.60 (0.28, 1.26) 0.14 (0.01, 0.25) 0.90 (0.35, 2.35) 0.75 (0.27, 2.03) 0.28 (0.12, 0.41) 1.16 (0.60, 2.23) 0.68 (0.31, 1.48)
2+ or worse 0.34 (0.08, 0.53) 0.98 (0.43, 2.23) 1.24 (0.53, 2.91) 0.17 (0.01, 0.30) 1.12 (0.42, 3.01) 0.90 (0.33, 2.40) 0.26 (0.09, 0.40) 1.08 (0.52, 2.24) 0.82 (0.32, 2.13)
Missing 0.27 (0.12, 0.39) 0.74 (0.41, 1.34) 0.91 (0.49, 1.69) 0.13 (0.02, 0.23) 0.87 (0.36, 2.08) 0.82 (0.30, 2.26) 0.21 (0.07, 0.33) 0.83 (0.41, 1.68) 0.93 (0.41, 2.11)
Snowballs No 0.35 (0.29, 0.40) 1 0.04 1 0.25 0.16 (0.11, 0.20) 1 0.10 1 0.18 0.26 (0.21, 0.31) 1 0.01 1 0.07
Yes 0.19 (0.06, 0.29) 0.48 (0.24, 0.96) 0.66 (0.32, 1.35) 0.06 (0, 0.13) 0.37 (0.11, 1.22) 0.39 (0.10, 1.56) 0.08 (0, 0.15) 0.27 (0.10, 0.77) 0.35 (0.11, 1.08)
Keratic precipitates No 0.35 (0.29, 0.40) 1 0.40 1 0.43 0.15 (0.11, 0.19) 1 0.92 1 0.30 0.25 (0.20, 0.30) 1 0.68 1 0.42
Yes 0.29 (0.14, 0.42) 0.81 (0.46, 1.44) 0.69 (0.37, 1.27) 0.13 (0.02, 0.23) 0.86 (0.35, 2.10) 0.70 (0.23, 2.12) 0.19 (0.06, 0.30) 0.72 (0.35, 1.49) 0.64 (0.29, 1.40)
Missing 0.22 (0.02, 0.37) 0.57 (0.22, 1.45) 0.74 (0.26, 2.10) 0.16 (0, 0.31) 1.12 (0.39, 3.21) 2.04 (0.72, 5.81) 0.23 (0.04, 0.39) 0.93 (0.39, 2.19) 1.38 (0.53, 3.58)
Peripheral anterior synechia No 0.33 (0.28, 0.38) 1 0.44 1 0.42 0.15 (0.10, 0.18) 1 0.26 1 0.47 0.24 (0.19, 0.28) 1 0.07 1 0.13
Yes 0.45 (0.01, 0.69) 1.48 (0.54, 4.03) 1.64 (0.49, 5.49) 0.26 (0, 0.47) 1.91 (0.62, 5.86) 1.50 (0.50, 4.50) 0.43 (0.13, 0.62) 2.04 (0.95, 4.36) 2.00 (0.81, 4.95)
Posterior synechia No 0.33 (0.27, 0.38) 1 0.53 1 0.005 0.14 (0.09, 0.18) 1 0.23 1 0.0501 0.23 (0.18, 0.28) 1 0.18 1 0.04
Yes 0.36 (0.27, 0.43) 1.11 (0.80, 1.53) 0.56 (0.38, 0.84) 0.18 (0.11, 0.24) 1.31 (0.84, 2.04) 0.61 (0.37, 1.0003) 0.28 (0.21, 0.35) 1.27 (0.89, 1.80) 0.64 (0.42, 0.99)
Band keratopathy No 0.32 (0.26, 0.38) 1 0.03 1 0.71 0.12 (0.08, 0.16) 1 0.003 1 0.02 0.21 (0.16, 0.26) 1 0.004 1 0.21
Yes 0.44 (0.33, 0.53) 1.51 (1.06, 2.14) 1.20 (0.77, 1.87) 0.26 (0.16, 0.34) 2.28 (1.41, 3.68) 2.06 (1.08, 3.90) 0.37 (0.27, 0.45) 1.90 (1.30, 2.77) 1.35 (0.85, 2.15)
Missing 0.22 (0.02, 0.38) 0.64 (0.25, 1.64) 0.98 (0.36, 2.66) 0.17 (0, 0.31) 1.44 (0.50, 4.16) 2.87 (1.01, 8.21) 0.24 (0.04, 0.39) 1.13 (0.48, 2.68) 1.92 (0.77, 4.76)
Immunosuppressive therapy/Biologics No 0.30 (0.23, 0.36) 1 0.06 1 0.31 0.14 (0.09, 0.18) 1 0.47 1 0.58 0.23 (0.17, 0.28) 1 0.41 1 1.00
Yes 0.39 (0.30, 0.46) 1.39 (0.99, 1.95) 1.21 (0.84, 1.76) 0.16 (0.10, 0.22) 1.19 (0.74, 1.93) 0.86 (0.49, 1.49) 0.26 (0.19, 0.33) 1.17 (0.80, 1.72) 0.999 (0.64, 1.56)
Systemic corticosteroids None 0.31 (0.25, 0.36) 1 0.01 1 0.38 0.15 (0.10, 0.19) 1 0.02 1 0.08 0.23 (0.17, 0.27) 1 0.003 1 0.14
≤7.5mg/day 0.33 (0.15, 0.47) 1.07 (0.58, 1.99) 1.05 (0.53, 2.07) 0.02 (0, 0.06) 0.12 (0.02, 0.88) 0.11 (0.01, 0.94) 0.19 (0.06, 0.30) 0.83 (0.40, 1.71) 0.85 (0.37, 1.91)
>7.5mg/day 0.50 (0.35, 0.62) 1.90 (1.23, 2.95) 1.39 (0.87, 2.22) 0.25 (0.11, 0.38) 1.88 (0.97, 3.63) 1.43 (0.68, 3.03) 0.41 (0.27, 0.53) 2.08 (1.31, 3.31) 1.69 (0.98, 2.92)
Topical corticosteroids None/day 0.18 (0.13, 0.24) 1 <0.001 1 <0.001 0.07 (0.04, 0.11) 1 <0.001 1 <0.001 0.12 (0.08, 0.16) 1 <0.001 1 <0.001
1 drop/day 0.13 (0.01, 0.24) 0.70 (0.27, 1.80) 0.75 (0.28, 2.03) 0.08 (0, 0.15) 1.07 (0.36, 3.17) 0.97 (0.29, 3.23) 0.07 (0, 0.15) 0.59 (0.18, 1.88) 0.58 (0.17, 2.01)
2 drops/day 0.36 (0.19, 0.49) 2.15 (1.16, 4.01) 3.06 (1.67, 5.60) 0.11 (0.01, 0.20) 1.56 (0.59, 4.11) 1.88 (0.66, 5.38) 0.29 (0.14, 0.41) 2.70 (1.45, 5.05) 3.10 (1.60, 6.01)
3 drops/day 0.46 (0.25, 0.62) 3.03 (1.62, 5.68) 3.57 (1.82, 7.02) 0.15 (0.02, 0.27) 2.15 (0.79, 5.85) 2.75 (1.03, 7.32) 0.20 (0.04, 0.34) 1.81 (0.75, 4.35) 2.35 (0.91, 6.07)
4 drops/day 0.57 (0.39, 0.69) 4.09 (2.50, 6.69) 4.61 (2.81, 7.57) 0.31 (0.17, 0.43) 4.76 (2.45, 9.24) 6.07 (2.79, 13.2) 0.53 (0.37, 0.66) 6.10 (3.61, 10.3) 6.67 (3.72, 12.0)
5–8 drops/day 0.60 (0.40, 0.73) 4.51 (2.68, 7.60) 5.55 (3.22, 9.59) 0.32 (0.12, 0.48) 5.00 (2.34, 10.7) 7.76 (3.03, 19.9) 0.44 (0.25, 0.58) 4.62 (2.54, 8.38) 5.21 (2.49, 10.9)
>8 drops/day 0.54 (0.31, 0.69) 3.77 (2.05, 6.91) 5.15 (2.52, 10.5) 0.36 (0.16, 0.52) 5.85 (2.77, 12.3) 8.77 (3.45, 22.3) 0.50 (0.29, 0.65) 5.53 (2.99, 10.2) 6.26 (3.08, 12.7)
Periocular corticosteroids No 0.32 (0.26, 0.37) 1 <0.001 1 <0.001 0.14 (0.10, 0.18) 1 <0.001 1 <0.001 0.23 (0.19, 0.28) 1 <0.001 1 <0.001
Yes 0.99 (0.90, 0.9997) 13.5 (7.37, 24.8) 7.96 (4.29, 14.7) 0.81 (0.22, 0.95) 10.9 (4.48, 26.4) 7.54 (2.71, 20.9) 0.97 (0.68, 0.996) 12.9 (6.40, 26.0) 7.31 (3.28, 16.3)
Intraocular corticosteroids No 0.33 (0.28, 0.38) 1 <0.001 1 0.02 0.15 (0.11, 0.19) 1 <0.001 1 0.004 0.24 (0.19, 0.28) 1 <0.001 1 <0.001
Yes >0.99 (0, 1) 69.6 (20.4, 238) 6.96 (1.41, 34.2) >0.99 (0, 1) 113 (31.0, 412) 18.1 (2.55, 129) >0.99 (0.89, 1) 92.0 (34.5, 245) 19.7 (4.45, 86.8)
*

IOP-Intraocular Pressure, CI-Confidence Interval, P-Probability, SITE-Systemic Immunosuppressive Therapy in Eye Diseases Study, n/a-Not Applicable, Hypotony was noted if any eye exhibited an episode of IOP ≤5mmHg.

Time-updated variables include: Cataract surgery, Pars plana vitrectomy (not retinal detachment), Retinal detachment surgery, Other eye history of IOP elevation, History of hypotony, Other eye history of hypotony, Visual acuity, Inflammatory activity, Anterior chamber cells, Vitreous cells, Vitreous haze, Snowballs, Keratic precipitates, Peripheral anterior synechia, Posterior synechia, Band keratopathy, Immunosuppressive therapy/Biologics, Systemic corticosteroids, Topical corticosteroids, Periocular corticosteroids and Intraocular corticosteroids. For time-varying characteristics, eyes potentially contribute partial time to more than one level of the covariate, so the numbers in each category cannot be calculated.

Multivariate: The variables by which risk was adjusted for were: Juvenile idiopathic arthritis, Cataract surgery, Pars plana vitrectomy (not retinal detachment), Uveitis category, Bilateral uveitis, Duration of uveitis prior to presentation, Other eye history of IOP elevation, Visual acuity, Anterior chamber cells, Snowballs, Peripheral anterior synechia, Band keratopathy, Immunosuppressive therapy/Biologics, Systemic corticosteroids, Topical corticosteroids and Periocular corticosteroids.