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. 2015 Jun 30;64(10):3564–3572. doi: 10.2337/db15-0022

Figure 2.

Figure 2

Acute hypoglycemia study. A: VMH administration of SGLT1 shRNA reduced SGLT1 mRNA by ∼53%. B: Plasma glucose concentrations during the clamp in control and SGLT1 knockdown (KD) groups. C: Diminished GIRs in SGLT1 KD compared with control animals. Increased plasma glucagon (D) and epinephrine (E) responses to hypoglycemia in SGLT1 KD compared with control rats. F: Hepatic glucose production (HGP) during hypoglycemia was 88% greater in the SGLT1 KD group than in controls. Data are mean ± SEM. *P < 0.05 vs. SGLT1 KD; ***P < 0.001 vs. SGLT1 KD.