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. 2015 Aug 6;156(10):3581–3595. doi: 10.1210/en.2015-1145

Figure 6.

Figure 6.

Genome-wide expression profiling of liver from KLF11−/− mice. GO Enrichment analysis of genes identified as significantly altered between Klf11−/− and Klf11+/+ mice (male and female) on CD and HFD (A). Biological processes of top ten GO-enriched terms are shown. Numbers in parentheses indicate number of genes within the GO term. Enrichment scores of more than or equal to 3 correspond to a P < .05. Additional GO cellular metabolic process analysis of genes identified as significantly altered (B). Enrichment scores indicated in parentheses. Genes altered in livers of Klf11−/− and Klf11+/+ mice are correlated between Affymetrix and PPAR pathway qPCR arrays (C). qPCR of select genes Adipor1, Fasn, Pck1, Pck2, and Scd1 confirms changes among Klf11−/− and Klf11+/+ female mice on CD and HFD (*, significant change P < .05, t test) (D). Predicted PPARγ target genes are altered in Klf11−/− liver pathways (E).