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. 2015 Jun 3;4(11):e1032492. doi: 10.1080/2162402X.2015.1032492

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© 2015 The Author(s). Published with license by Taylor & Francis

© Panagiotis Karagiannis, Federica Villanova, Debra H Josephs, Isabel Correa, Mieke Van Hemelrijck, Carl Hobbs, Louise Saul, Isioma U Egbuniwe, Isabella Tosi, Kristina M Ilieva, Emma Kent, Eduardo Calonje, Mark Harries, Ian Fentiman, Joyce Taylor-Papadimitriou, Joy Burchell, James F Spicer, Katie E Lacy, Frank O Nestle, and Sophia N Karagiannis

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 4. — IgG4+ cell infiltrates are detected in melanoma skin tumors. A tissue microarray (TMA; BioMax, n = 256) consisting of melanoma skin tumors (n = 108), melanoma lymph nodes metastases (n = 56), distant organ metastases (n = 60) and healthy skin (n = 32) specimens (top panel) was examined for the presence of IgG4 by immunohistochemistry. IgG4 positive infiltrates were detected by alkaline phosphatase (in red, selected areas shown by black arrows) and sections were counterstained in hematoxylin (in blue). Representative images of IgG4 immunohistochemical staining for IgG4⁺ infiltration revealed positive staining in skin lesions (top and second panels), lymph node and distant metastases (third panel), while staining was less frequent in healthy skin (bottom panel). Black bar represents 800 µm (third bottom right panel).