Abstract
Ten patients with severe dyspnoea and chronic airflow obstruction entered a randomised double-blind crossover trial comparing the effect of carbimazole 80 mg daily for two months with that of placebo. Assessment of thyroid function, lung function, and exercise tolerance was performed monthly. The mean free thyroxine index after two months of carbimazole was significantly lower at 64.1 (+/- 10.5, SEM) than the 89.1 (+/- 3.8) while on placebo. Serum tri-iodothyronine was reduced and thyroid stimulating hormone raised while on the active drug. There was no significant difference in the 12-minute walking distance (TMD), the rating of perceived exertion during the TMD, the oxygen cost score, the dyspnoea grade, the resting arterialised capillary blood gas tensions or the resting minute ventilation. During a progressive exercise test to exhaustion on a cycle ergometer, there was no significant difference in the minute ventilation, heart rate, blood gas tensions at exhaustion, or the total work done. There were no symptoms or signs of hypothyroidism. Lung function (FEV1, FVC, TLC, KCO) was unchanged. Thus a 28% reduction in the free thyroxine index produced no symptomatic or objective benefit in exercise tolerance in patients with severe airflow obstruction. These results provide no support for the use of carbimazole in chronic airflow obstruction.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BISHOP J. M., DONALD K. W., WADE O. L. Circulatory dynamics at rest and on exercise in the hyperkinetic states. Clin Sci. 1955 May;14(2):329–360. [PubMed] [Google Scholar]
- BLAKEMORE W. S., FORSTER R. E., MORTON J. W., OGILVIE C. M. A standardized breath holding technique for the clinical measurement of the diffusing capacity of the lung for carbon monoxide. J Clin Invest. 1957 Jan;36(1 Pt 1):1–17. doi: 10.1172/JCI103402. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bernard E., Israel L., Vincent J., Gamain B., Coby J. La thyroidectomie par l'iode 131 chez les insuffisants respiratoires graves. (Etude de trois cas) J Fr Med Chir Thorac. 1965 Sep-Oct;19(6):703–711. [PubMed] [Google Scholar]
- Borg G. Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med. 1970;2(2):92–98. [PubMed] [Google Scholar]
- Burack R., Edwards R. H., Green M., Jones N. L. The response to exercise before and after treatment of myxedema with thyroxine. J Pharmacol Exp Ther. 1971 Jan;176(1):212–219. [PubMed] [Google Scholar]
- Butland R. J., Pang J. A., Geddes D. M. Thyroxine and dyspnoea in emphysema. Br J Dis Chest. 1981 Jan;75(1):96–98. doi: 10.1016/s0007-0971(81)80014-9. [DOI] [PubMed] [Google Scholar]
- HURST A., LEVINE M. H., RICH D. R. Radioactive iodine in the management of patients with severe pulmonary emphysema. Ann Allergy. 1955 Jul-Aug;13(4):393–397. [PubMed] [Google Scholar]
- HURST A., LEVINE M. H. Radioactive iodine in treatment of pulmonary emphysema. Rocky Mt Med J. 1955 Feb;52(2 Pt 1):129–131. [PubMed] [Google Scholar]
- Jones N. L. Pulmonary gas exchange during exercise in patients with chronic airway obstruction. Clin Sci. 1966 Aug;31(1):39–50. [PubMed] [Google Scholar]
- LEVINE M. H., HURST A. RADIOACTIVE IODINE IN PULMONARY EMPHYSEMA. Rocky Mt Med J. 1963 Sep;60:35–PASSIM. [PubMed] [Google Scholar]
- MASSUMI R. A., WINNACKER J. L. SEVERE DEPRESSION OF THE RESPIRATORY CENTER IN MYXEDEMA. Am J Med. 1964 Jun;36:876–882. doi: 10.1016/0002-9343(64)90117-2. [DOI] [PubMed] [Google Scholar]
- Massey D. G., Becklake M. R., McKenzie J. M., Bates D. V. Circulatory and ventilatory response to exercise in thyrotoxicosis. N Engl J Med. 1967 May 18;276(20):1104–1112. doi: 10.1056/NEJM196705182762002. [DOI] [PubMed] [Google Scholar]
- McGavin C. R., Artvinli M., Naoe H., McHardy G. J. Dyspnoea, disability, and distance walked: comparison of estimates of exercise performance in respiratory disease. Br Med J. 1978 Jul 22;2(6132):241–243. doi: 10.1136/bmj.2.6132.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGavin C. R., Gupta S. P., McHardy G. J. Twelve-minute walking test for assessing disability in chronic bronchitis. Br Med J. 1976 Apr 3;1(6013):822–823. doi: 10.1136/bmj.1.6013.822. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NORDQVIST P., DHUNER K. G., STENBERG K., ORNDAHL G. Myxoedema coma and carbon dioxide-retention. Acta Med Scand. 1960 Mar 10;166:189–194. [PubMed] [Google Scholar]
- Stein M., Kimbel P., Johnson R. L. PULMONARY FUNCTION IN HYPERTHYROIDISM. J Clin Invest. 1961 Feb;40(2):348–363. doi: 10.1172/JCI104262. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILSON W. R., BEDELL G. N. The pulmonary abnormalities in myxedema. J Clin Invest. 1960 Jan;39:42–55. doi: 10.1172/JCI104025. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zwillich C. W., Matthay M., Potts D. E., Adler R., Hofeldt F., Weil J. V. Thyrotoxicosis: comparison of effects of thyroid ablation and beta-adrenergic blockade on metabolic rate and ventilatory control. J Clin Endocrinol Metab. 1978 Mar;46(3):491–500. doi: 10.1210/jcem-46-3-491. [DOI] [PubMed] [Google Scholar]
- Zwillich C. W., Pierson D. J., Hofeldt F. D., Lufkin E. G., Weil J. V. Ventilatory control in myxedema and hypothyroidism. N Engl J Med. 1975 Mar 27;292(13):662–665. doi: 10.1056/NEJM197503272921302. [DOI] [PubMed] [Google Scholar]