Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1982 Feb;37(2):114–117. doi: 10.1136/thx.37.2.114

Serum studies of leucocyte elastase in acute and chronic lung diseases.

R A Stockley, K Ohlsson
PMCID: PMC459260  PMID: 6919307

Abstract

Immunoreactive leucocyte elastase was measured in the serum of patients with chronic obstructive bronchitis. No evidence was found to demonstrate the release of this enzyme in the pulmonary circulation. However the average serum concentrations (573 . 0 micrograms/l; SD +/- 261 . 0) were higher (2p less than 0 . 001) in this group of patients than in age matched control subjects (355 . 2 micrograms/l; SD +/- 274 . 8). Further studies confirmed this finding but patients with other active lung diseases had similarly increased leucocyte elastase concentration in the serum. This suggests that a raised serum leucocyte elastase concentration is a feature of active lung diseases and not a feature of obstructive bronchitis alone.

Full text

PDF
114

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Janoff A., Sloan B., Weinbaum G., Damiano V., Sandhaus R. A., Elias J., Kimbel P. Experimental emphysema induced with purified human neutrophil elastase: tissue localization of the instilled protease. Am Rev Respir Dis. 1977 Mar;115(3):461–478. doi: 10.1164/arrd.1977.115.3.461. [DOI] [PubMed] [Google Scholar]
  2. Kramps J. A., Bakker W., Dijkman J. H. A matched-pair study of the leukocyte elastase-like activity in normal persons and in emphysematous patients with and without alpha 1-antitrypsin deficiency. Am Rev Respir Dis. 1980 Feb;121(2):253–261. doi: 10.1164/arrd.1980.121.2.253. [DOI] [PubMed] [Google Scholar]
  3. Lam S., Abboud R. T., Chan-Yeung M., Rushton J. M. Neutrophil elastase and pulmonary function in subjects with intermediate alpha1-antitrypsin deficiency (MZ phenotype). Am Rev Respir Dis. 1979 Jun;119(6):941–951. doi: 10.1164/arrd.1979.119.6.941. [DOI] [PubMed] [Google Scholar]
  4. Ohlsson K., Laurell C. B. The disappearance of enzyme-inhibitor complexes from the circulation of man. Clin Sci Mol Med. 1976 Jul;51(1):87–92. doi: 10.1042/cs0510087. [DOI] [PubMed] [Google Scholar]
  5. Ohlsson K., Olsson A. S. Immunoreactive granulocyte elastase in human serum. Hoppe Seylers Z Physiol Chem. 1978 Nov;359(11):1531–1539. doi: 10.1515/bchm2.1978.359.2.1531. [DOI] [PubMed] [Google Scholar]
  6. Ohlsson K., Tegner H. Granulocyte collagenase, elastase and plasma protease inhibitors in purulent sputum. Eur J Clin Invest. 1975 Jun 12;5(3):221–227. doi: 10.1111/j.1365-2362.1975.tb00448.x. [DOI] [PubMed] [Google Scholar]
  7. Rodriguez J. R., Seals J. E., Radin A., Lin J. S., Mandl I., Turino G. M. Neutrophil lysosomal elastase activity in normal subjects and in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1979 Mar;119(3):409–417. doi: 10.1164/arrd.1979.119.3.409. [DOI] [PubMed] [Google Scholar]
  8. SIMON G. RADIOLOGY AND EMPHYSEMA. Clin Radiol. 1964 Oct;15:293–306. doi: 10.1016/s0009-9260(64)80001-5. [DOI] [PubMed] [Google Scholar]
  9. Stockley R. A., Burnett D. Alpha,-antitrypsin and leukocyte elastase in infected and noninfected sputum. Am Rev Respir Dis. 1979 Nov;120(5):1081–1086. doi: 10.1164/arrd.1979.120.5.1081. [DOI] [PubMed] [Google Scholar]
  10. Stockley R. A., Burnett D., Bradwell A. R. An arterio-venous study of serum alpha1-antitrypsin in patients with chronic bronchitis. Clin Chim Acta. 1978 Aug 15;88(1):127–133. doi: 10.1016/0009-8981(78)90159-6. [DOI] [PubMed] [Google Scholar]
  11. Thurlbeck W. M., Simon G. Radiographic appearance of the chest in emphysema. AJR Am J Roentgenol. 1978 Mar;130(3):429–440. doi: 10.2214/ajr.130.3.429. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES