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. 1982 Feb;37(2):118–123. doi: 10.1136/thx.37.2.118

Mechanisms of sulphur dioxide induced bronchoconstriction in normal and asthmatic man.

P D Snashall, C Baldwin
PMCID: PMC459261  PMID: 6805088

Abstract

We have examined the inhibitory effect of atropine and sodium cromoglycate (SCG) on the bronchial response to sulphur dioxide (SO2) in groups of normal and asthmatic subjects. Eleven normal subjects were premedicated with propranolol (100 mg orally) one hour before each experiment. After baseline measurements of specific airways conductance (sGaw) the subject inhaled an aerosol from a Wright nebuliser for five minutes. In separate experiments this contained water (control), atropine methonitrate (0 . 2%), or SCG (1%). Fifteen minutes later sGaw was remeasured and the subject then breathed SO2 (8 ppm) for three minutes through the mouth. Specific airways conductance was measured for the duration of the subsequent response. Intervals between experiments on any one subject were one week or more. After control SO2 inhalation sGaw decreased in all subjects (mean 34 +/- 17 (SD)%). Atropine and SCG significantly inhibited the SO2 response (p less than 0 . 01 for both). After atropine the mean decrease in sGaw was 13 +/- 24%; after SCG 16 +/- 12% (range -3- + 55%). With atropine the degree of inhibition was inversely related to the subject's responsiveness to the control SO2 inhalation (r = 0 . 75; p less than 0 . 01). In four asthmatics (without beta-blockade and with lower SO2 exposure) atropine did not inhibit the SO2 response; SCG had a similar effect to that seen in normal subjects. Therefore, vagal efferent mechanisms are involved in the bronchial response to SO2 in normal subjects, but the lack of inhibition caused by atropine in hyperreactive normal and asthmatic subjects suggests that vagal mechanisms are not important in the causation of hyperreactivity to SO2. The mechanism of inhibition with SCG is unknown.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cox J. S., Beach J. E., Blair A. M., Clarke A. J., King J., Lee T. B., Loveday D. E., Moss G. F., Orr T. S., Ritchie J. T. Disodium cromoglycate (Intal). Adv Drug Res. 1970;5:115–196. [PubMed] [Google Scholar]
  2. Cox J. S. Disodium cromoglycate (FPL 670) ('Intal'): a specific inhibitor of reaginic antibody-antigen mechanisms. Nature. 1967 Dec 30;216(5122):1328–1329. doi: 10.1038/2161328a0. [DOI] [PubMed] [Google Scholar]
  3. DUBOIS A. B., BOTELHO S. Y., COMROE J. H., Jr A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest. 1956 Mar;35(3):327–335. doi: 10.1172/JCI103282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FRANK N. R., AMDUR M. O., WHITTENBERGER J. L. A COMPARISON OF THE ACUTE EFFECTS OF SO2 ADMINISTERED ALONE OR IN COMBINATION WITH NACL PARTICLES ON THE RESPIRATORY MECHANICS OF HEALTHY ADULTS. Air Water Pollut. 1964 Feb;8:125–133. [PubMed] [Google Scholar]
  5. Jackson D. M., Richards I. M. The effects of sodium cromoglycate on histamine aerosol-induced reflex bronchoconstriction in the anaesthetized dog. Br J Pharmacol. 1977 Oct;61(2):257–262. doi: 10.1111/j.1476-5381.1977.tb08413.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jones R. S. Significance of effect of beta blockade on ventilatory function in normal and asthmatic subjects. Thorax. 1972 Sep;27(5):572–576. doi: 10.1136/thx.27.5.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jonsen A. R. Editorial: Ethicist's heyday. Am Rev Respir Dis. 1976 Jan;113(1):5–6. doi: 10.1164/arrd.1976.113.1.5. [DOI] [PubMed] [Google Scholar]
  8. Kerr J. W., Govindaraj M., Patel K. R. Effect of alpha-receptor blocking drugs and disodium cromoglyate on histamine hypersensitivity in bronchial asthma. Br Med J. 1970 Apr 18;2(5702):139–141. doi: 10.1136/bmj.2.5702.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. NADEL J. A., SALEM H., TAMPLIN B., TOKIWA Y. MECHANISM OF BRONCHOCONSTRICTION DURING INHALATION OF SULFUR DIOXIDE. J Appl Physiol. 1965 Jan;20:164–167. doi: 10.1152/jappl.1965.20.1.164. [DOI] [PubMed] [Google Scholar]
  10. SIM V. M., PATTLE R. E. Effect of possible smog irritants on human subjects. J Am Med Assoc. 1957 Dec 14;165(15):1908–1913. doi: 10.1001/jama.1957.02980330010003. [DOI] [PubMed] [Google Scholar]
  11. STRANDBERG L. G. SO2 ABSORPTION IN THE RESPIRATORY TRACT. STUDIES ON THE ABSORPTION IN RABBIT, ITS DEPENDANCE ON CONCENTRATION AND BREATHING PHASE. Arch Environ Health. 1964 Aug;9:160–166. doi: 10.1080/00039896.1964.10663814. [DOI] [PubMed] [Google Scholar]
  12. Speizer F. E., Frank N. R. A comparison of changes in pulmonary flow resistance in healthy volunteers acutely exposed to SO-2 by mouth and by nose. Br J Ind Med. 1966 Jan;23(1):75–79. doi: 10.1136/oem.23.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]

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