Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1982 Feb;37(2):129–132. doi: 10.1136/thx.37.2.129

Exercise testing in pulmonary sarcoidosis

CG Ingram 1, Patricia C Reid 1, RN Johnston 1
PMCID: PMC459263  PMID: 7080012

Abstract

The change in transfer coefficient (Kco) with increasing heart rate during exercise was studied in 25 normal subjects and in 21 patients with pulmonary sarcoidosis. The slope of the Kco response against heart rate was found to be 0·0053 mmol min−1 kPa−1 l−1 per beat in the normal group but in many of the patients was two standard deviations or more below this normal slope, even when their routine function tests were normal. This response of Kco to exercise is a more sensitive index of changed function than more routine function tests in pulmonary sarcoidosis.

Full text

PDF
129

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson T. W., Shephard R. J. The effects of hyperventilation and exercise upon the pulmonary diffusing capacity. Respiration. 1968;25(6):465–484. doi: 10.1159/000192581. [DOI] [PubMed] [Google Scholar]
  2. Freyschuss U., Holmgren A. On the variation of D-LCO with increasing oxygen uptake during exercise in healthy ordinarily untrained young men and women. Acta Physiol Scand. 1965 Nov;65(3):193–206. doi: 10.1111/j.1748-1716.1965.tb04263.x. [DOI] [PubMed] [Google Scholar]
  3. HAMER N. A. CHANGES IN THE COMPONENTS OF THE DIFFUSING CAPACITY IN PULMONARY SARCOIDOSIS. Thorax. 1963 Sep;18:275–287. doi: 10.1136/thx.18.3.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. JOHNSON R. L., Jr, TAYLOR H. F., LAWSON W. H., Jr MAXIMAL DIFFUSING CAPACITY OF THE LUNG FOR CARBON MONOXIDE. J Clin Invest. 1965 Mar;44:349–355. doi: 10.1172/JCI105148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Levinson R. S., Metzger L. F., Stanley N. N., Kelsen S. G., Altose M. D., Cherniack N. S., Brody J. S. Airway function in sarcoidosis. Am J Med. 1977 Jan;62(1):51–59. doi: 10.1016/0002-9343(77)90349-7. [DOI] [PubMed] [Google Scholar]
  6. MARSHALL R., SMELLIE H., BAYLIS J. H., HOYLE C., BATES D. V. Pulmonary function in sarcoidosis. Thorax. 1958 Mar;13(1):48–58. doi: 10.1136/thx.13.1.48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Marshall R., Karlish A. J. Lung function in sarcoidosis. An investigation of the disease as seen at a clinic in England and a comparison of the value of various lung function tests. Thorax. 1971 Jul;26(4):402–405. doi: 10.1136/thx.26.4.402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Radwan L., Grebska E., Koziorowski A. Small airways function in pulmonary sarcoidosis. Scand J Respir Dis. 1978 Feb;59(1):37–43. [PubMed] [Google Scholar]
  9. SILTZBACH L. E. Pulmonary sarcoidosis. Am J Surg. 1955 Feb;89(2):556–568. doi: 10.1016/0002-9610(55)90100-8. [DOI] [PubMed] [Google Scholar]
  10. Sharma O. P., Colp C., Williams M. H., Jr Course of pulmonary sarcoidosis with and without corticosteriod therapy as determined by pulmonary function studies. Am J Med. 1966 Oct;41(4):541–551. doi: 10.1016/0002-9343(66)90216-6. [DOI] [PubMed] [Google Scholar]
  11. Studdy P., Bird R., James D. G. Serum angiotensin-converting enzyme (SACE) in sarcoidosis and other granulomatous disorders. Lancet. 1978 Dec 23;2(8104-5):1331–1334. doi: 10.1016/s0140-6736(78)91972-4. [DOI] [PubMed] [Google Scholar]
  12. Turiaf J., Basset G., Georges R. Données à long terme de l'exploration fonctionnelle respiratoire chez les sujets guérins de sarcoïdose pulmonaire. Poumon Coeur. 1969;25(1):1–15. [PubMed] [Google Scholar]
  13. Turton C. W., Grundy E., Firth G., Mitchell D., Rigden B. G., Turner-Warwick M. Value of measuring serum angiotensin I converting enzyme and serum lysozyme in the management of sarcoidosis. Thorax. 1979 Feb;34(1):57–62. doi: 10.1136/thx.34.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES