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. 1982 Aug;37(8):602–606. doi: 10.1136/thx.37.8.602

Interaction of immune complexes and T suppressor cells in sarcoidosis.

J D Williams, M D Smith, B H Davies
PMCID: PMC459383  PMID: 6217575

Abstract

Circulating immune complexes were present in half of 31 patients with sarcoidosis and raised levels were associated with low numbers of T suppressor cells (T gamma- and Fc gamma-receptor-positive lymphocytes). Incubation of T cells with trypsin restored the percentage of T gamma cells to within or above the normal range. Incubation of normal lymphocytes with sarcoid immune complexes significantly reduced the number of detectable T gamma cells. Preincubation of normal lymphocytes with circulating immune complexes significantly reduced their blastogenic response to concanavalin A. These studies suggest an interaction between immune complexes and T suppressor cells in sarcoidosis and emphasise the importance of immune complexes in modulating the immune response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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