Abstract
Naftidrofuryl enhances oxidative phosphorylation and might therefore be expected to improve exercise tolerance and breathlessness in advanced chronic bronchitis. This hypothesis was tested in a four-week placebo-controlled trial in 11 bronchitic patients. Seven patients completed the study. There was no evidence of any benefit from naftidrofuryl either subjectively or after a 12-minute walking test.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- McGavin C. R., Artvinli M., Naoe H., McHardy G. J. Dyspnoea, disability, and distance walked: comparison of estimates of exercise performance in respiratory disease. Br Med J. 1978 Jul 22;2(6132):241–243. doi: 10.1136/bmj.2.6132.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGavin C. R., Gupta S. P., Lloyd E. L., McHardy G. J. Physical rehabilitation for the chronic bronchitic: results of a controlled trial of exercises in the home. Thorax. 1977 Jun;32(3):307–311. doi: 10.1136/thx.32.3.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGavin C. R., Gupta S. P., McHardy G. J. Twelve-minute walking test for assessing disability in chronic bronchitis. Br Med J. 1976 Apr 3;1(6013):822–823. doi: 10.1136/bmj.1.6013.822. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shaw S. W., Johnson R. H. The effect of naftidrofuryl on the metabolic response to exercise in man. Acta Neurol Scand. 1975 Sep;52(3):231–237. doi: 10.1111/j.1600-0404.1975.tb05777.x. [DOI] [PubMed] [Google Scholar]
- Woodcock A. A., Gross E. R., Geddes D. M. Drug treatment of breathlessness: contrasting effects of diazepam and promethazine in pink puffers. Br Med J (Clin Res Ed) 1981 Aug 1;283(6287):343–346. doi: 10.1136/bmj.283.6287.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodcock A. A., Gross E. R., Geddes D. M. Oxygen relieves breathlessness in "pink puffers". Lancet. 1981 Apr 25;1(8226):907–909. doi: 10.1016/s0140-6736(81)91612-3. [DOI] [PubMed] [Google Scholar]