Journal club
4081 Transposition of exercise protocols: cardiovascular response to exercise in patients with transposition of the great arteries
R. Sless and N. J. Stern
Special section: Twenty-five years of CLC transport proteins
4083 Twenty-five years of CLC chloride transport proteins
Peying Fong
4085 In the beginning: a personal reminiscence on the origin and legacy of ClC-0, the ‘ Torpedo Cl− channel’
Christopher Miller
4091 Discovery of CLC transport proteins: cloning, structure, function and pathophysiology
Thomas J. Jentsch
4111 Regulatory–auxiliary subunits of CLC chloride channel–transport proteins
Alejandro Barrallo-Gimeno, Antonella Gradogna, Ilaria Zanardi, Michael Pusch and Raúl Estévez
4129 Structure and gating of CLC channels and exchangers
Alessio Accardi
4139 A tale of two CLCs: biophysical insights toward understanding ClC-5 and ClC-7 function in endosomes and lysosomes
Giovanni Zifarelli
4151 Chloride transporters and receptor-mediated endocytosis in the renal proximal tubule
Olivier Devuyst and Alessandro Luciani
4165 Structural determinants of interaction, trafficking and function in the ClC-2/MLC1 subunit GlialCAM involved in leukodystrophy
Xavier Capdevila-Nortes, Elena Jeworutzki, Xabier Elorza-Vidal, Alejandro Barrallo-Gimeno, Michael Pusch and Raúl Estévez
4181 ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype–phenotype correlation
P. Imbrici, L. Maggi, G. F. Mangiatordi, M. M. Dinardo, C. Altamura, R. Brugnoni, D. Alberga, G. Lauria Pinter, G. Ricci, G. Siciliano, R. Micheli, G. Annicchiarico, G. Lattanzi, O. Nicolotti, L. Morandi, P. Bernasconi, J.-F. Desaphy, R. Mantegazza and D. Conte Camerino
Cardiovascular
4201 Differential thermosensitivity in mixed syndrome cardiac sodium channel mutants
Mena Abdelsayed, Colin H. Peters and Peter C. Ruben
Respiratory
4225 Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO2: role of carotid body CO2
Curtis. A. Smith, Grégory M. Blain, Kathleen S. Henderson and Jerome A. Dempsey
Muscle
4245 Effect of hyperinsulinaemia–hyperaminoacidaemia on leg muscle protein synthesis and breakdown: reassessment of the two-pool arterio-venous balance model
Gordon I. Smith, Bruce W. Patterson, Seth J. Klein and Bettina Mittendorfer
4259 Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation
Ruth E. Tanner, Lucille B. Brunker, Jakob Agergaard, Katherine M. Barrows, Robert A. Briggs, Oh Sung Kwon, Laura M. Young, Paul N. Hopkins, Elena Volpi, Robin L. Marcus, Paul C. LaStayo and Micah J. Drummond
4275 Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise
Andrew Philp, Simon Schenk, Joaquin Perez-Schindler, D. Lee Hamilton, Leigh Breen, Erin Laverone, Stewart Jeromson, Stuart M. Phillips and Keith Baar
Integrative
4285 Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training
Llion A. Roberts, Truls Raastad, James F. Markworth, Vandre C. Figueiredo, Ingrid M. Egner, Anthony Shield, David Cameron-Smith, Jeff S. Coombes and Jonathan M. Peake
Editor-in-Chief
David J. Paterson Oxford, UK
Deputy Editors-in-Chief
Asia/Pacific
Yoshihiro Kubo Okazaki, Japan
Europe
Julian Paton Bristol, UK
The Americas
Kim E. Barrett San Diego, CA, USA
Senior Reviews Editor
Ian D. Forsythe Leicester, UK
Senior CrossTalk Editor
Jerome A. Dempsey Madison, WI, USA
CrossTalk Editor
Peying Fong Manhattan, KS, USA
CrossTalk Editor – Neuroscience
Derek Bowie Montreal, QC, Canada
Senior Editors
Donald M. Bers Davis, CA, USA
Simon Gandevia Sydney, Australia
Michael C. Hogan La Jolla, CA, USA
Gianmaria Maccaferri Chicago, IL, USA
Ole Paulsen Cambridge, UK
Scott K. Powers Gainesville, FL, USA
Ingrid H. Sarelius Rochester, NY, USA
Statistics Consultant
Alan Batterham Middlesbrough, UK
Editors
David Adams Melbourne, Australia
Bruno Allard Lyon, France
Andrew Allen Melbourne, Australia
Jaideep S. Bains Calgary, Canada
Kenneth M. Baldwin Irvine, CA, USA
Laura Bennet Auckland, New Zealand
Derek Bowie Montreal, Canada
Keith Buckler Oxford, UK
Julie Chan Kaohsiung, Taiwan
Nisha Charkoudian Rochester, MN, USA
Diego Contreras Philadelphia, PA, USA
Kim Dora Oxford, UK
Peying Fong Manhattan, KS, USA
Mike Frenneaux Aberdeen, UK
Gregory Funk Edmonton, Canada
Wayne Giles Calgary, Canada
Dino Giussani Cambridge, UK
Ann Goodchild Sydney, Australia
Alexander Gourine London, UK
Kathy Griendling Atlanta, GA, USA
David Grundy Sheffield, UK
Christian Hansel Chicago, IL, USA
Ylva Hellsten Copenhagen, Denmark
Troy Hornberger Madison, USA
Virginia H. Huxley Columbia, MO, USA
Tadashi Isa Okazaki, Japan
Masanobu Kano Tokyo, Japan
Andrew King Oxford, UK
Bjorn Knollmann Nashville, TN, USA
Anne McArdle Liverpool, UK
Andrew McCulloch San Diego, CA, USA
Giovanni Mann London, UK
Walter Marcotti Sheffield, UK
Gary M. Mawe Burlington, VT, USA
Gero Miesenböck Oxford, UK
Bettina Mittendorfer St Louis, USA
Kathleen G. Morgan Boston, MA, USA
Ruth Murrell-Lagnado Cambridge, UK
Matthew Nolan Edinburgh, UK
Yasushi Okamura Osaka, Japan
Anant Parekh Oxford, UK
Reinhold Penner Honolulu, HI, USA
Frank Powell San Diego, CA, USA
Nanduri Prabhakar Chicago, IL, USA
Louise Robson Sheffield, UK
Jochen Roeper Frankfurt, Germany
Stephen D. Roper Miami, FL, USA
Michael Sanguinetti Salt Lake City, UT, USA
Harold D. Schultz Omaha, NE, USA
Steve Segal Columbia, MO, USA
Keith Sharkey Calgary, Canada
Michael Shattock London, UK
Hartwig R. Siebner Copenhagen, Denmark
Jesper Sjöström Montreal, Canada
Bruce Smaill Auckland, New Zealand
Nicolas Smith Auckland, New Zealand
Kenneth W. Spitzer Salt Lake City, UT, USA
Javier Stern Augusta, GA, USA
Janet Taylor Sydney, Australia
W. Rowland Taylor Portland, OR, USA
Katalin Toth Quebec City, Canada
Jamie Vandenberg Sydney, Australia
Richard G. Wise Cardiff, UK
Zhuan Zhou Beijing, China
Consulting Editors
Frances M. Ashcroft Oxford, UK
Jonathan Ashmore London, UK
David Attwell London, UK
John I. Bell Oxford, UK
Colin Blakemore Oxford, UK
Kay E. Davies Oxford, UK
Peter Hunter Auckland, New Zealand
Erwin Neher Göttingen, Germany
Roger Nicoll San Francisco, CA, USA
Denis Noble Oxford, UK
Ole Petersen Cardiff, UK
Mu-Ming Poo Berkeley, CA, USA
Peter Ratcliffe Oxford, UK
Carol V. Robinson Oxford, UK
Bert Sakmann Heidelberg, Germany
Roger Y. Tsien San Diego, CA, USA
Editorial Staff
Sally Howells Managing Editor
Ann Watson Peer Review Manager
Diana Jones Peer Review Coordinator
Marie Allan Peer Review Coordinator
Priya Mistry Editorial Administrator
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