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. 1982 Dec;37(12):906–912. doi: 10.1136/thx.37.12.906

Accuracy of postmortem radiography of excised air-inflated human lungs in assessment of pulmonary emphysema.

S Sutinen, P Lohela, P Pääkkö, R Lahti
PMCID: PMC459456  PMID: 7170681

Abstract

The accuracy of radiography of excised air-inflated lungs in assessing pulmonary emphysema at necropsy was evaluated in a series of 107 adults who had died in hospital by reading the radiographs and examining the pathological specimens independently. The radiographic and pathological assessments of the severity of emphysema correlated significantly (r = 0.87, p less than 0.0001). Mild emphysema was recognised radiographically in 88.7% and moderate in 94.9% of the lungs. One of 16 normal lungs (6.3%) was radiographically diagnosed as showing mild emphysema. Six out of 53 lungs (11.3%) with mild emphysema were radiographically assessed as normal. The correct radiographic recognition of the type of emphysema was possible in 86% of lungs with mild and 97.4% with moderate centrilobular emphysema and in 81.8% and 87.5% respectively of the lungs with mild and moderate paracicatricial emphysema, but in only 25.0% and 28.6% of the lungs with mild and moderate panlobular emphysema. Radiographical diagnosis of centrilobular and paracicatricial emphysema was verified pathologically in all lungs showing mild emphysema, but that of panlobular emphysema in only 66.7%. Radiography of excised air-inflated lungs is a rapid, convenient, and reliable method of recognising and assessing the severity of appreciable degrees of centrilobular and paracicatricial emphysema, but less reliable in recognising panlobular emphysema. After the procedure the specimen remains available for almost any other technique.

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Selected References

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  1. Dunnill M. S. Radiology as an adjunct to pathology in elucidation of pulmonary disease at necropsy. Eur J Respir Dis. 1981 Oct;62(5):287–288. [PubMed] [Google Scholar]
  2. Hasleton P. S. The internal surface area of the lung in emphysema. Pathol Eur. 1976;11(3):211–218. [PubMed] [Google Scholar]
  3. Markarian B. A simple method of inflation--fixation and air drying of lungs. Am J Clin Pathol. 1975 Jan;63(1):20–24. doi: 10.1093/ajcp/63.3.20. [DOI] [PubMed] [Google Scholar]
  4. Nicklaus T. M., Stowell D. W., Christiansen W. R., Renzetti A. D., Jr The accuracy of the roentgenologic diagnosis of chronic pulmonary emphysema. Am Rev Respir Dis. 1966 Jun;93(6):889–899. doi: 10.1164/arrd.1966.93.6.889. [DOI] [PubMed] [Google Scholar]
  5. Pratt P. C., Kilburn K. H. A modern concept of the emphysemas based on correlations of structure and function. Hum Pathol. 1970 Sep;1(3):443–463. doi: 10.1016/s0046-8177(70)80077-6. [DOI] [PubMed] [Google Scholar]
  6. Päkkö P. Pattern recognition in radiographs of excised air-inflated human lungs. III Chronic interstitial and granulomatous inflammation, scars and lymphangitis carcinomatosa in non-emphysematous lungs. Eur J Respir Dis. 1981 Oct;62(5):289–296. [PubMed] [Google Scholar]
  7. Päkkö P., Sutinen S., Lahti R. Pattern recognition in radiographs of excised air-inflated human lungs. I. Circulatory disorders in non-emphysematous lungs. Eur J Respir Dis. 1981 Feb;62(1):21–32. [PubMed] [Google Scholar]
  8. Päkkö P., Sutinen S., Lahti R. Pattern recognition in radiographs of excised air-inflated human lungs. II. Acute inflammation in non-emphysematous lungs. Eur J Respir Dis. 1981 Feb;62(1):33–45. [PubMed] [Google Scholar]
  9. SUTINEN S., CHRISTOFORIDIS A. J., KLUGH G. A., PRATT P. C. ROENTGENOLOGIC CRITERIA FOR THE RECOGNITION OF NONSYMPTOMATIC PULMONARY EMPHYSEMA. CORRELATION BETWEEN ROENTGENOLOGIC FINDINGS AND PULMONARY PATHOLOGY. Am Rev Respir Dis. 1965 Jan;91:69–76. doi: 10.1164/arrd.1965.91.1.69. [DOI] [PubMed] [Google Scholar]
  10. Sutinen S., Päkko P., Lahti R. Post-mortem inflation, radiography, and fixation of human lungs. A method for radiological and pathological correlations and morphometric studies. Scand J Respir Dis. 1979 Feb;60(1):29–35. [PubMed] [Google Scholar]
  11. Sutinen S., Päkkö P., Lohela P., Lahti R. Pattern recognition in radiographs of excised air-inflated human lungs. IV Emphysema alone and with other common lesions. Eur J Respir Dis. 1981 Oct;62(5):297–314. [PubMed] [Google Scholar]
  12. Sutinen S., Vaajalahti P., Päkkö P. Prevalence, severity, and types of pulmonary emphysema in a population of deaths in a Finnish city. Correlation with age, sex and smoking. Scand J Respir Dis. 1978 Apr;59(2):101–115. [PubMed] [Google Scholar]
  13. Thurlbeck W. M., Dunnill M. S., Hartung W., Heard B. E., Heppleston A. G., Ryder R. C. A comparison of three methods of measuring emphysema. Hum Pathol. 1970 Jun;1(2):215–226. doi: 10.1016/s0046-8177(70)80035-1. [DOI] [PubMed] [Google Scholar]
  14. Whimster W. F. Techniques for the examination of excised lungs. Hum Pathol. 1970 Jun;1(2):305–314. doi: 10.1016/s0046-8177(70)80042-9. [DOI] [PubMed] [Google Scholar]

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