Table 4.

Top 25 highly expressed ion channel genes in HEMs.

Gene Name (Gene ID)	Average FPKM ± SEM
chloride intracellular channel 1 (CLIC1)	242.8 ± 28.6
purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7)	78.4 ± 16.7
TRP cation channel, subfamily V, member 2 (TRPV2)	75.6 ± 16.2
chloride channel, voltage-sensitive 3 (CLCN3)	72.4 ± 13.5
chloride intracellular channel 4 (CLIC4)	71.4 ± 16.7
TRP cation channel, subfamily M, member 1 (TRPM1)	57.8 ± 9.4
two pore segment channel 2 (TPCN2)	52.1 ± 7.2
chloride channel, voltage-sensitive 7 (CLCN7)	50.6 ± 8.0
polycystic kidney disease 2 (PKD2)	31.6 ± 7.6
bestrophin 1 (BEST1)	31.3 ± 7.4
pannexin 1 (PANX1)	25.2 ± 2.7
anoctamin 10 (ANO10)	23.5 ± 3.1
anoctamin 6 (ANO6)	21.7 ± 4.0
potassium channel, subfamily J, member 13 (KCNJ13)	17.6 ± 9.4
purinergic receptor P2X, ligand-gated ion channel, 4 (P2RX4)	17.1 ± 1.7
mucolipin 1 (MCOLN1, TRPML1)	16.8 ± 3.3
mucolipin 3 (MCOLN3, TRPML3)	15.5 ± 5.6
inositol 1,4,5-trisphosphate receptor, type 3 (ITPR3)	12.6 ± 3.0
chloride channel, voltage-sensitive 6 (CLCN6)	11.8 ± 2.3
potassium channel, delayed-rectifier, subfamily S, member 3 (KCNS3)	10.7 ± 2.3
TRP cation channel, subfamily M, member 7 (TRPM7)	10.2 ± 3.1
gap junction protein, gamma 1, 45kDa (GJC1)	9.5 ± 2.7
two pore segment channel 1 (TPCN1)	8.8 ± 2.3
chloride channel, voltage-sensitive 5 (CLCN5)	5.1 ± 0.6
gap junction protein, alpha 3, 46kDa (GJA3)	4.8 ± 0.3

The highest expressed ion channels in melanocytes were obtained by averaging their FPKM from each library. Nine out of the 25 genes are chloride channels (shown in dark grey background). Ion channels reported to be important for melanocyte function are in bold.