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. 1983 Feb;38(2):108–112. doi: 10.1136/thx.38.2.108

Beta-blockers in bronchial asthma: effect of propranolol and pindolol on large and small airways.

D Patakas, V Argiropoulou, G Louridas, V Tsara
PMCID: PMC459498  PMID: 6344309

Abstract

In 11 asthmatic subjects the relative magnitude and the site of airway bronchoconstriction were compared after the oral administration of 40 mg of propranolol and 2.5 mg of pindolol and the magnitude and site of bronchodilation produced by 0.5 mg subcutaneous terbutaline were tested after pretreatment with propranolol and pindolol. Specific airway conductance (sGaw) and peak expiratory flow rate (PEFR), both believed to reflect changes in large airways, and capacity isoflow (Ciso-v) and delta Vmax50, both believed to reflect changes in small airways, were determined before and after administration of placebo, pindolol, and propranolol. Treatments were given double blind and in random order. After the administration of propranolol we noted a significant bronchoconstrictive effect in the large airways (mean values of PEFR and sGaw, expressed as percentages of control values, decreased by 87.4% +/- 13.2% and 43.3% +/- 8.9%) and in the small airways (mean value of Ciso-v increased by 20.6% +/- 4.7% and that of delta Vmax50 decreased by 50% +/- 11.9% of control). By contrast, pindolol produced no significant effect on sGaw or PEFR but the tests of small airway function showed significant bronchoconstriction (mean values of Ciso-v increased by 12.9% +/- 2.6% and those of delta Vmax50 decreased by 47.2% +/- 9.2%). This action makes pindolol potentially dangerous in asthmatic patients. The bronchodilator action of terbutaline on large airways is diminished after the use of both propranolol and pindolol.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRISCOE W. A., DUBOIS A. B. The relationship between airway resistance, airway conductance and lung volume in subjects of different age and body size. J Clin Invest. 1958 Sep;37(9):1279–1285. doi: 10.1172/JCI103715. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Conolly M. E., Kersting F., Dollery C. T. The clinical pharmacology of beta-adrenoceptor-blocking drugs. Prog Cardiovasc Dis. 1976 Nov-Dec;19(3):203–234. doi: 10.1016/0033-0620(76)90016-5. [DOI] [PubMed] [Google Scholar]
  3. DUBOIS A. B., BOTELHO S. Y., COMROE J. H., Jr A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest. 1956 Mar;35(3):327–335. doi: 10.1172/JCI103282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Decalmer P. B., Chatterjee S. S., Cruickshank J. M., Benson M. K., Sterling G. M. Beta-blockers and asthma. Br Heart J. 1978 Feb;40(2):184–189. doi: 10.1136/hrt.40.2.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Despas P. J., Leroux M., Macklem P. T. Site of airway obstruction in asthma as determined by measuring maximal expiratory flow breathing air and a helium-oxygen mixture. J Clin Invest. 1972 Dec;51(12):3235–3243. doi: 10.1172/JCI107150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hutcheon M., Griffin P., Levison H., Zamel N. Volume of isoflow. A new test in detection of mild abnormalities of lung mechanics. Am Rev Respir Dis. 1974 Oct;110(4):458–465. doi: 10.1164/arrd.1974.110.4.458. [DOI] [PubMed] [Google Scholar]
  7. Johnsson G., Svedmyr N., Thiringer G. Effects of intravenous propranolol and metoprolol and their interaction with isoprenaline on pulmonary function, heart rate and blood pressure in asthmatics. Eur J Clin Pharmacol. 1975 Apr 4;8(3-4):175–180. doi: 10.1007/BF00567111. [DOI] [PubMed] [Google Scholar]
  8. Macdonald J. B., Cole T. J. The flow-volume loop: reproducibility of air and helium-based tests in normal subjects. Thorax. 1980 Jan;35(1):64–69. doi: 10.1136/thx.35.1.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McGavin C. R., Williams I. P. The effects of oral propranolol and metoprolol on lung function and exercise performance in chronic airways obstruction. Br J Dis Chest. 1978 Oct;72(4):327–332. [PubMed] [Google Scholar]
  10. Paterson J. W. Beta-adrenergic blocking drugs. Br Med J. 1971 Jun 12;2(5762):652–652. doi: 10.1136/bmj.2.5762.652-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Tashkin D. P., Trevor E., Chopra S. K., Taplin G. V. Sites of airway dilatation in asthma following inhaled versus subcutaneous terbutaline. Comparison of physiologic tests with radionuclide lung images. Am J Med. 1980 Jan;68(1):14–26. doi: 10.1016/0002-9343(80)90156-4. [DOI] [PubMed] [Google Scholar]

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