Abstract
In a survey of 1000 patients with tuberculosis 28 were found to have miliary disease. Half of these patients were over 60 years old. Anorexia and weight loss were present in 19 (70%) and pyrexia in 17 (63%). A factor predisposing to tuberculosis or a history of recent contact was found in 12 (43%), and 21 (75%) had positive cultures. Seventeen (61%) had classical miliary shadowing while four (14%) had cryptic miliary tuberculosis with no radiological evidence of tuberculosis. The remaining seven patients (25%) had radiological changes consistent with pulmonary tuberculosis, but no miliary shadows. Of those who completed chemotherapy, only five (42%) received 18 months' treatment. Nine patients (32%) died from their miliary tuberculosis. Failure to consider the diagnosis, leading to a delay in starting chemotherapy, appeared to be a major problem.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barling R. W., Selkon J. B. The penetration of antibiotics into cerebrospinal fluid and brain tissue. J Antimicrob Chemother. 1978 May;4(3):203–227. doi: 10.1093/jac/4.3.203. [DOI] [PubMed] [Google Scholar]
- Cameron S. J., Horne N. W. The effect of tuberculosis and ist treatment on erythropoiesis and folate activity. Tubercle. 1971 Mar;52(1):37–48. doi: 10.1016/0041-3879(71)90029-8. [DOI] [PubMed] [Google Scholar]
- MEDD W. E., HAYHOE F. G. Tuberculous miliary necrosis with pancytopenia. Q J Med. 1955 Oct;24(96):351–364. [PubMed] [Google Scholar]
- MORROW L. B., ANDERSON R. E. ACTIVE TUBERCULOSIS IN LEUKEMIA. MALIGNANT LYMPHOMA AND MYELOFIBROSIS. Arch Pathol. 1965 May;79:484–493. [PubMed] [Google Scholar]
- Millar J. W., Horne N. W. Tuberculosis in immunosuppressed patients. Lancet. 1979 Jun 2;1(8127):1176–1178. doi: 10.1016/s0140-6736(79)91852-x. [DOI] [PubMed] [Google Scholar]
- Monie R. D., Hunter A. M., Rocchiccioli K. M., White J. P., Campbell I. A., Kilpatrick G. S. Management of extra-pulmonary tuberculosis (excluding miliary and meningeal) in south and west Wales (1976-8). Br Med J (Clin Res Ed) 1982 Aug 7;285(6339):415–418. doi: 10.1136/bmj.285.6339.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Monie R. D., Hunter A. M., Rocchiccioli K., White J., Campbell I. A., Kilpatrick G. S. Survey of pulmonary tuberculosis in south and west Wales (1976-8). Br Med J (Clin Res Ed) 1982 Feb 20;284(6315):571–573. doi: 10.1136/bmj.284.6315.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OSWALD N. C. ACUTE TUBERCULOSIS AND GRANULOCYTIC DISORDERS. Br Med J. 1963 Dec 14;2(5371):1489–1496. doi: 10.1136/bmj.2.5371.1489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Proudfoot A. T., Akhtar A. J., Douglas A. C., Horne N. W. Miliary tuberculosis in adults. Br Med J. 1969 May 3;2(5652):273–276. doi: 10.1136/bmj.2.5652.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RODIN A. E., HNATKO S. I. NON-REACTIVE TUBERCULOSIS. Can Med Assoc J. 1963 Oct 19;89:817–820. [PMC free article] [PubMed] [Google Scholar]
- Stephens M. E., Craft J., Peters T. J., Hoffbrand A. V. Oral contraceptives and folate metabolism. Clin Sci. 1972 Apr;42(4):405–414. doi: 10.1042/cs0420405. [DOI] [PubMed] [Google Scholar]