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. 1983 Jun;38(6):458–462. doi: 10.1136/thx.38.6.458

Inhalation challenge with specific grass pollen antigens in asthmatics and the effect of lodoxamide tromethamine.

R W Parrish, B H Davies
PMCID: PMC459583  PMID: 6136101

Abstract

Highly purified species-specific grass pollen antigens were used for inhalation bronchial challenge in 12 patients with atopic asthma. This was found to result in reproducible experimental asthma. Lodoxamide tromethamine was administered by inhalation in two different doses, 0.01 mg and 0.1 mg, to each patient, in double-blind, random, placebo-controlled manner, 15 minutes before pollen inhalation. It was found to have a significant protective action at both doses (p less than 0.05), but it produced troublesome side effects at the higher dose of 0.1 mg.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Case R. L., Rogers P. B., VanArsdel P. P., Jr, Altman L. C. The protective effect of lodoxamide on antigen-induced bronchospasm. An orally active antiallergic drug. JAMA. 1982 Feb 5;247(5):661–664. [PubMed] [Google Scholar]
  2. Chai H., Farr R. S., Froehlich L. A., Mathison D. A., McLean J. A., Rosenthal R. R., Sheffer A. L., Spector S. L., Townley R. G. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol. 1975 Oct;56(4):323–327. doi: 10.1016/0091-6749(75)90107-4. [DOI] [PubMed] [Google Scholar]
  3. Cockcroft D. W., Ruffin R. E., Dolovich J., Hargreave F. E. Allergen-induced increase in non-allergic bronchial reactivity. Clin Allergy. 1977 Nov;7(6):503–513. doi: 10.1111/j.1365-2222.1977.tb01481.x. [DOI] [PubMed] [Google Scholar]
  4. Empey D. W., Laitinen L. A., Jacobs L., Gold W. M., Nadel J. A. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 1976 Feb;113(2):131–139. doi: 10.1164/arrd.1976.113.2.131. [DOI] [PubMed] [Google Scholar]
  5. Frigas E., Reed C. E. Effect of iodoxamide ethyl on allergy skin tests. J Allergy Clin Immunol. 1980 Apr;65(4):257–262. doi: 10.1016/0091-6749(80)90152-9. [DOI] [PubMed] [Google Scholar]
  6. Johnson H. G., VanHout C. A., Wright J. B. Inhibition of allergic reactions by cromoglycate and by a new anti-allergy drug U-42,585E. I. Activity in rats. Int Arch Allergy Appl Immunol. 1978;56(5):416–423. doi: 10.1159/000232051. [DOI] [PubMed] [Google Scholar]
  7. Johnson H. G., VanHout C. A., Wright J. B. Inhibition of allergic reactions by cromoglycate and by a new antiallergy drug U-42,585E. II. Activity in primates against aerosolized Ascaris suum antigen. Int Arch Allergy Appl Immunol. 1978;56(6):481–487. doi: 10.1159/000232062. [DOI] [PubMed] [Google Scholar]
  8. Jones D. G., Kay A. B. Inhibition of eosinophil chemotaxis by the antagonist of slow reacting substance of anaphylaxis--compound FPL 55712. J Pharm Pharmacol. 1974 Nov;26(11):917–918. doi: 10.1111/j.2042-7158.1974.tb09208.x. [DOI] [PubMed] [Google Scholar]
  9. Taylor A. J., Davies R. J., Hendrick D. J., Pepys J. Recurrent nocturnal asthmatic reactions to bronchial provocation tests. Clin Allergy. 1979 May;9(3):213–219. doi: 10.1111/j.1365-2222.1979.tb01544.x. [DOI] [PubMed] [Google Scholar]
  10. Ungerer R. G., Tashkin D. P., Siegel S. C., Deutsch R. I. Effect of inhaled iodoxamide tromethamine in prevention of antigen-induced bronchospasm. J Allergy Clin Immunol. 1981 Dec;68(6):471–478. doi: 10.1016/0091-6749(81)90201-3. [DOI] [PubMed] [Google Scholar]
  11. Watt G. D., Bui T. C., Bewtra A. K., Townley R. G. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286–294. doi: 10.1016/0091-6749(80)90023-8. [DOI] [PubMed] [Google Scholar]

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