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. 1983 Oct;38(10):751–754. doi: 10.1136/thx.38.10.751

Dosage and delivery of nebulised beta agonists in hospital.

J N Stainforth, R A Lewis, A E Tattersfield
PMCID: PMC459651  PMID: 6139891

Abstract

A questionnaire was sent to physicians with an interest in chest disease to determine the dose and method of delivery of nebulised beta agonists in hospital. All of the 67 physicians replying gave beta agonists by nebuliser, and all reported either salbutamol (72%) or terbutaline (10%) as the drug they prescribed most commonly (18% gave either drug). There was a fivefold difference in the dose of salbutamol they prescribed most commonly (range 2.5-12.5 mg, mode 5 mg), a 20 fold difference in the volume of diluent solution used (range 0.5-10 ml, mode 2 ml), and a 10 fold variation in the flow rates of gas driving the nebuliser (range 1-10 1/min, mode 4 1/min). There are therefore very large variations in the dose and method of delivery of beta agonists nebulised in hospital. Studies attempting to determine the optimum dose of beta agonist for use in a nebuliser need to take the type of nebuliser, diluent volume, and gas flow rate into account.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asmundsson T., Johnson R. F., Kilburn K. H., Goodrich J. K. Efficiency of nebulizers for depositing saline in human lung. Am Rev Respir Dis. 1973 Sep;108(3):506–512. doi: 10.1164/arrd.1973.108.3.506. [DOI] [PubMed] [Google Scholar]
  2. Bennis J., Svedmyr N. A controlled comparison of salbutamol and terbutaline inhaled by IPPV in asthmatic patients: a dose-response study. Scand J Respir Dis Suppl. 1977;101:113–117. [PubMed] [Google Scholar]
  3. Blackwell E. W., Briant R. H., Conolly M. E., Davies D. S., Dollery C. T. Metabolism of isoprenaline after aerosol and direct intrabronchial administration in man and dog. Br J Pharmacol. 1974 Apr;50(4):587–591. doi: 10.1111/j.1476-5381.1974.tb08593.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Editorial: Lymphocyte subpopulations in chronic inflammatory diseases. Br Med J. 1975 Apr 5;2(5961):1–2. doi: 10.1136/bmj.2.5961.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hetzel M. R., Clark T. J. Comparison of intravenous and aerosol salbutamol. Br Med J. 1976 Oct 16;2(6041):919–919. doi: 10.1136/bmj.2.6041.919. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Larsson S., Svedmyr N. Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol in asthmatics. Am Rev Respir Dis. 1977 Nov;116(5):861–869. doi: 10.1164/arrd.1977.116.5.861. [DOI] [PubMed] [Google Scholar]
  7. Lawford P., Jones B. J., Milledge J. S. Comparison of intravenous and nebulised salbutamol in initial treatment of severe asthma. Br Med J. 1978 Jan 14;1(6105):84–84. doi: 10.1136/bmj.1.6105.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Neville E., Corris P. A., Vivian J., Nariman S., Gibson G. J. Nebulised salbutamol and angina. Br Med J (Clin Res Ed) 1982 Sep 18;285(6344):796–797. doi: 10.1136/bmj.285.6344.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Newman S. P., Pavia D., Clarke S. W. How should a pressurized beta-adrenergic bronchodilator be inhaled? Eur J Respir Dis. 1981 Feb;62(1):3–21. [PubMed] [Google Scholar]
  10. Newman S. P., Pavia D., Morén F., Sheahan N. F., Clarke S. W. Deposition of pressurised aerosols in the human respiratory tract. Thorax. 1981 Jan;36(1):52–55. doi: 10.1136/thx.36.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ruffin R. E., Obminski G., Newhouse M. T. Aerosol salbutamol administration by IPPB: lowest effective dose. Thorax. 1978 Dec;33(6):689–693. doi: 10.1136/thx.33.6.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stead W. W., Dutt A. K. Chemotherapy for tuberculosis today. Am Rev Respir Dis. 1982 Mar;125(3 Pt 2):94–101. doi: 10.1164/arrd.1982.125.3P2.94. [DOI] [PubMed] [Google Scholar]
  13. Walters E. H., Cockroft A., Griffiths T., Rocchiccioli K., Davies B. H. Optimal dose of salbutamol respiratory solution: comparison of three doses with plasma levels. Thorax. 1981 Aug;36(8):625–628. doi: 10.1136/thx.36.8.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Webber B. A., Collins J. V., Branthwaite M. A. Severe acute asthma: a comparison of three methods of inhaling salbutamol. Br J Dis Chest. 1982 Jan;76(1):69–74. [PubMed] [Google Scholar]
  15. Williams S. J., Winner S. J., Clark T. J. Comparison of inhaled and intravenous terbutaline in acute severe asthma. Thorax. 1981 Aug;36(8):629–631. doi: 10.1136/thx.36.8.629. [DOI] [PMC free article] [PubMed] [Google Scholar]

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