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. 2015 Oct 2;201(2):377–402. doi: 10.1534/genetics.115.179457

Figure 3.

Figure 3

Expression of pathogenic human polyQ protein in Drosophila causes severe eye degeneration that is suppressed by Hsp70. Eyes (A–C) and retinal sections (D–F) of flies expressing expanded polyQ protein alone or with human Hsp70, using the gmr-GAL4 driver to express UAS-transgenes. (A and D) Control eye structure. These are flies expressing human hsp70 gene and the eye structure is nearly normal. (B and E) Flies expressing the expanded polyglutamine protein SCA3tr-Q78. These flies have severely degenerate eyes that lack pigment and show severe loss of structure. (C and F) Flies expressing both SCA3tr-Q78 and Hsp70. Hsp70 expression mitigates the degenerative effects of the pathogenic polyQ protein to restore the external eye completely and the internal eye back toward normal [reprinted from Warrick et al. (1999)].