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. 2015 Oct 6;23(10):1889–1899. doi: 10.1016/j.str.2015.07.016

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

PepT1 and PepT2 are Modular Proteins with Functionally Distinct Domains

(A) Homology model of the human PepT1 transporter generated using the crystal structure of MmPepT1^ECD (colored blue to red as in Figure 1B) and the recently determined bacterial homolog PepT_So representing the transmembrane portion of the transporter (shown in gray). The peptide-binding site is highlighted (magenta).

(B) Kinetic analysis of Gly-Sar uptake in human PepT1 and PepT2 using the TEVC method.

(C) Kinetic analysis of Gly-Sar uptake in the PepT2^ΔECD, PepT2^T1ECD, and PepT1^D573A constructs.

(D) K_i values for the different constructs for lysyl-lysine and cefaclor are shown, indicating no effect of removing the ECD on peptide or drug uptake in PepT2.