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. 1984 Jan;39(1):46–51. doi: 10.1136/thx.39.1.46

Sex hormone suppression and sexual impotence in hypoxic pulmonary fibrosis.

P D Semple, G H Beastall, T M Brown, K W Stirling, R J Mills, W S Watson
PMCID: PMC459720  PMID: 6695352

Abstract

Eight men with hypoxia associated with idiopathic pulmonary fibrosis were studied. Serum testosterone concentrations were low in two subjects and fell to subnormal levels in two others as the clinical condition and arterial oxygen tension deteriorated. There was a significant correlation between serum testosterone concentrations and arterial oxygen tensions (p less than 0.05). Three patients showed evidence of suppression of luteinising hormone secretion at the pituitary level. Only occasional abnormalities of thyroid and prolactin concentrations were noted. Most of the men suffered from organic sexual impotence, which is considered to be due at least in part to endocrine disturbance. These findings are similar to observations in patients with hypoxic chronic obstructive airways disease and support the hypothesis that hypoxia of lung disease suppresses the hypothalamo-pituitary-testicular axis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIRATH G., KJELLMER I., SANDQVIST L. Spirometric studies in normal subjects. II. Ventilatory capacity tests in adults. Acta Med Scand. 1963 Feb;173:193–198. [PubMed] [Google Scholar]
  2. BURROWS B., KASIK J. E., NIDEN A. H., BARCLAY W. R. Clinical usefulness of the single-breath pulmonucy diffusing capacity test. Am Rev Respir Dis. 1961 Dec;84:789–806. doi: 10.1164/arrd.1961.84.6.789. [DOI] [PubMed] [Google Scholar]
  3. CRIDLAND M. D. Seasonal incidence of clinical onset of Hodgkin's disease. Br Med J. 1961 Sep 2;2(5252):621–623. doi: 10.1136/bmj.2.5252.621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Caminos-Torres R., Ma L., Snyder P. J. Gynecomastia and semen abnormalities induced by spironolactone in normal men. J Clin Endocrinol Metab. 1977 Aug;45(2):255–260. doi: 10.1210/jcem-45-2-255. [DOI] [PubMed] [Google Scholar]
  5. Challand G. S., Ratcliffe W. A., Ratcliffe J. G. Semi-automated radioimmunoassays for total serum thyroxine and triiodothyronine. Clin Chim Acta. 1975 Apr 2;60(1):25–32. doi: 10.1016/0009-8981(75)90176-x. [DOI] [PubMed] [Google Scholar]
  6. Cowden E. A., Ratcliffe W. A., Beastall G. H., Ratcliffe J. G. Laboratory assessment of prolactin status. Ann Clin Biochem. 1979 May;16(3):113–121. doi: 10.1177/000456327901600126. [DOI] [PubMed] [Google Scholar]
  7. De Groot G. W., Faiman C., Winter J. S. Cyclophosphamide and the prepubertal gonad: a negative report. J Pediatr. 1974 Jan;84(1):123–125. doi: 10.1016/s0022-3476(74)80572-x. [DOI] [PubMed] [Google Scholar]
  8. Fairley K. F., Barrie J. U., Johnson W. Sterility and testicular atrophy related to cyclophosphamide therapy. Lancet. 1972 Mar 11;1(7750):568–569. doi: 10.1016/s0140-6736(72)90358-3. [DOI] [PubMed] [Google Scholar]
  9. Fisher C., Schiavi P., Lear H., Edwards A., Davis D. M., Witkin A. P. The assessment of nocturnal REM erection in the differential diagnosis of sexual impotence. J Sex Marital Ther. 1975 Summer;1(4):277–289. doi: 10.1080/00926237508403702. [DOI] [PubMed] [Google Scholar]
  10. Guerra-García R., Velásquez A., Coyotupa J. A test of endocrine gonadal function in men: urinary testosterone after the injection of HCG. A different response of the high altitude native. J Clin Endocrinol Metab. 1969 Feb;29(2):179–182. doi: 10.1210/jcem-29-2-179. [DOI] [PubMed] [Google Scholar]
  11. Hall R., Amos J., Ormston B. J. Radioimmunoassay of human serum thyrotrophin. Br Med J. 1971 Mar 13;1(5749):582–585. doi: 10.1136/bmj.1.5749.582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hosking D. J., Bennet T., Hampton J. R., Evans D. F., Clark A. J., Robertson G. Diabetic impotence: studies of nocturnal erection during REM sleep. Br Med J. 1979 Dec 1;2(6202):1394–1396. doi: 10.1136/bmj.2.6202.1394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Marmorston J., Weiner J. M., Hopkins C. E., Stern E. Abnormalities in urinary hormone patterns in lung cancer and emphysema. Cancer. 1966 Jul;19(7):985–995. doi: 10.1002/1097-0142(196607)19:7<985::aid-cncr2820190712>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  14. Rose L. I., Underwood R. H., Newmark S. R., Kisch E. S., Williams G. H. Pathophysiology of spironolactone-induced gynecomastia. Ann Intern Med. 1977 Oct;87(4):398–403. doi: 10.7326/0003-4819-87-4-398. [DOI] [PubMed] [Google Scholar]
  15. Semple P. D., Beastall G. H., Watson W. S., Hume R. Hypothalamic-pituitary dysfunction in respiratory hypoxia. Thorax. 1981 Aug;36(8):605–609. doi: 10.1136/thx.36.8.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Semple P. D., Beastall G. H., Watson W. S., Hume R. Serum testosterone depression associated with hypoxia in respiratory failure. Clin Sci (Lond) 1980 Jan;58(1):105–106. doi: 10.1042/cs0580105. [DOI] [PubMed] [Google Scholar]
  17. Semple P. D., Brown T. M., Beastall G. H., Semple C. G. Sexual dysfunction and erectile impotence in chronic obstructive pulmonary disease. Chest. 1983 Mar;83(3):587–588. doi: 10.1378/chest.83.3.587b. [DOI] [PubMed] [Google Scholar]
  18. Stearns E. L., MacDonnell J. A., Kaufman B. J., Padua R., Lucman T. S., Winter J. S., Faiman C. Declining testicular function with age. Hormonal and clinical correlates. Am J Med. 1974 Nov;57(5):761–766. doi: 10.1016/0002-9343(74)90850-x. [DOI] [PubMed] [Google Scholar]
  19. d'A Semple P., Watson W. S., Beastall G. H., Bethel M. I., Grant J. K., Hume R. Diet, absorption, and hormone studies in relation to body weight in obstructive airways disease. Thorax. 1979 Dec;34(6):783–788. doi: 10.1136/thx.34.6.783. [DOI] [PMC free article] [PubMed] [Google Scholar]

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