Skip to main content
Thorax logoLink to Thorax
. 1984 Jan;39(1):52–56. doi: 10.1136/thx.39.1.52

Jaundice after open heart surgery: a prospective study.

C M Chu, C H Chang, Y F Liaw, M J Hsieh
PMCID: PMC459721  PMID: 6695353

Abstract

One hundred and fifty four consecutive adult patients having cardiac surgery for a variety of cardiac lesions were evaluated prospectively for postoperative jaundice, those with a raised preoperative serum bilirubin concentration (greater than 34 mumol/l or 2 mg/100 ml) being excluded. The incidence of early postoperative jaundice, as defined by a serum bilirubin concentration of 50 mumol/l (3.0 mg/100 ml) or greater, was 23.4%. The jaundice was mild (bilirubin concentration 51-100 mumol/l (3.0-6.0 mg/100 ml] in 26 patients (16.9%) and moderate to severe (greater than 100 mumol/l (6.0 mg/100 ml] in 10 patients (6.5%). Important contributing factors were the preoperative severity of right heart failure (raised right atrial pressure at heart catheterisation) and hypotension or hypoxaemia and the amount of blood transfused during or shortly after surgery. Age, sex, underlying cardiac lesion, whether halothane was used, operative procedure, duration of cardiopulmonary bypass, and presence or absence of hepatitis B surface antigen were not predictive of postoperative jaundice.

Full text

PDF
52

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen M. N., Gabrieli E., Zizzi J. A. Chronic hemolysis in patients with ball-valve prostheses. J Thorac Cardiovasc Surg. 1965 Oct;50(4):501–510. [PubMed] [Google Scholar]
  2. BLUMBERG B. S., ALTER H. J., VISNICH S. A "NEW" ANTIGEN IN LEUKEMIA SERA. JAMA. 1965 Feb 15;191:541–546. doi: 10.1001/jama.1965.03080070025007. [DOI] [PubMed] [Google Scholar]
  3. Chen P. C., Liaw Y. F., Chang-Chien C. S., Wu C. S., Chen L. [Hepatitis after halothane exposure (author's transl)]. Taiwan Yi Xue Hui Za Zhi. 1978 Sep;77(9):685–691. [PubMed] [Google Scholar]
  4. DYKES M. H., WALZER S. G., SLATER E. M., GIBSON J. M., ELLIS D. S. ACUTE PARENCHYMATOUS HEPATIC DISEASE FOLLOWING GENERAL ANESTHESIA: CLINICAL APPRAISAL OF HEPATOTOXICITY FOLLOWING ADMINISTRATION OF HALOTHANE. JAMA. 1965 Aug 2;193:339–344. doi: 10.1001/jama.1965.03090050015005. [DOI] [PubMed] [Google Scholar]
  5. Dodson M. E., Richards T. G. A prospective study of changes in liver function after operation under two forms of general anaesthesia. Br J Anaesth. 1972 Jan;44(1):47–60. doi: 10.1093/bja/44.1.47. [DOI] [PubMed] [Google Scholar]
  6. Evans C., Evans M., Pollock A. V. The incidence and causes of postoperative jaundice. A prospective study. Br J Anaesth. 1974 Jul;46(7):520–525. doi: 10.1093/bja/46.7.520. [DOI] [PubMed] [Google Scholar]
  7. Kingsley D. P. Hepatic damage following profound hypothermia and extracorporeal circulation in man. Thorax. 1966 Jan;21(1):91–98. doi: 10.1136/thx.21.1.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Klatskin G., Kimberg D. V. Recurrent hepatitis attributable to halothane sensitization in an anesthetist. N Engl J Med. 1969 Mar 6;280(10):515–522. doi: 10.1056/NEJM196903062801001. [DOI] [PubMed] [Google Scholar]
  9. Koff R. S. Postoperative jaundice. Med Clin North Am. 1975 Jul;59(4):823–829. doi: 10.1016/s0025-7125(16)31978-2. [DOI] [PubMed] [Google Scholar]
  10. Liaw Y. F., Sung J. L. Liver biopsy in asymptomatic carriers of HBsAg. Gastroenterology. 1979 May;76(5 Pt 1):1084–1084. [PubMed] [Google Scholar]
  11. Lockey E., McIntyre N., Ross D. N., Brookes E., Sturridge M. F. Early jaundice after open-heart surgery. Thorax. 1967 Mar;22(2):165–169. doi: 10.1136/thx.22.2.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MUSHIN W. W., ROSEN M., BOWEN D. J., CAMPBELL H. HALOTHANE AND LIVER DYSFUNCTION: A RETROSPECTIVE STUDY. Br Med J. 1964 Aug 8;2(5405):329–341. doi: 10.1136/bmj.2.5405.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mundth E. D., Keller A. R., Austen W. G. Progressive hepatic and renal failure associated with low cardiac output following open-heart surgery. J Thorac Cardiovasc Surg. 1967 Feb;53(2):275–284. [PubMed] [Google Scholar]
  14. POPPER H. Liver disease-morphologic considerations. Am J Med. 1954 Jan;16(1):98–117. doi: 10.1016/0002-9343(54)90326-5. [DOI] [PubMed] [Google Scholar]
  15. REFSUM H. E. ARTERIAL HYPOXAEMIA, SERUM ACTIVITIES OF GO-T, GP-T AND LDH, AND CENTRILOBULAR LIVER CELL NECROSIS IN PULMONARY INSUFFICIENCY. Clin Sci. 1963 Dec;25:369–374. [PubMed] [Google Scholar]
  16. Reed W. D., Williams R. Halothane hepatitis as seen by the physician. Br J Anaesth. 1972 Sep;44(9):935–940. doi: 10.1093/bja/44.9.935. [DOI] [PubMed] [Google Scholar]
  17. Robinson J. S., Cole F. R., Gibson P., Simpson J. A. Jaundice following cardiopulmonary bypass. Thorax. 1967 May;22(3):232–237. doi: 10.1136/thx.22.3.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. SCHMID M., HEFTI M. L., GATTIKER R., KISTLER H. J., SENNING A. BENIGN POSTOPERATIVE INTRAHEPATIC CHOLESTASIS. N Engl J Med. 1965 Mar 18;272:545–550. doi: 10.1056/NEJM196503182721101. [DOI] [PubMed] [Google Scholar]
  19. SHERLOCK S. The liver in heart failure; relation of anatomical, functional, and circulatory changes. Br Heart J. 1951 Jul;13(3):273–293. doi: 10.1136/hrt.13.3.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sanderson R. G., Ellison J. H., Benson J. A., Jr, Starr A. Jaundice following open-heart surgery. Ann Surg. 1967 Feb;165(2):217–224. doi: 10.1097/00000658-196702000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Trowell J., Peto R., Smith A. C. Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium. Lancet. 1975 Apr 12;1(7911):821–824. [PubMed] [Google Scholar]
  22. Wu J. S., Chen C. H., Chiang Y. H., Lee Y. C., Lee M. H., Ko Y. C., Hu H. T. Hepatitis B virus infection in Taiwan with reference to anti-HBc versus HBsAg and anti-HBs. Taiwan Yi Xue Hui Za Zhi. 1980 Sep;79(9):760–767. [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES