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. 1984 Feb;39(2):150–154. doi: 10.1136/thx.39.2.150

Importance of viruses and Legionella pneumophila in respiratory exacerbations of young adults with cystic fibrosis.

J Efthimiou, M E Hodson, P Taylor, A G Taylor, J C Batten
PMCID: PMC459743  PMID: 6422578

Abstract

From January to April 1980 46 young adults with cystic fibrosis were studied for evidence of infection with a wide variety of microorganisms, including viruses and Legionella pneumophila. Two groups of patients were investigated: a "deteriorated" group of 24 patients who had experienced an increase in lower respiratory tract symptoms and fall in lung function values in the course of one month before the start of the study and a "stable" group of 22 patients with no such deterioration. All serological tests were repeated at one month and then one year after the beginning of the study. A fourfold rise in titres of antibodies to various viruses, Mycoplasma pneumoniae, and Coxiella burnetii was obtained in seven (29%) of the deteriorated group but in only one (4.5%) of the stable group (p less than 0.05). One other patient showed a fourfold rise in L pneumophila antibody titre (on the basis of the indirect fluorescent antibody test), which was accompanied by a respiratory illness consistent with legionnaires' disease. Eight of the 46 patients (17.4%) had demonstrable titres of antibody against L pneumophila (1/32 or above).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSEN D. H. Cystic fibrosis of the pancreas. J Chronic Dis. 1958 Jan;7(1):58–90. doi: 10.1016/0021-9681(58)90185-1. [DOI] [PubMed] [Google Scholar]
  2. DI SANT'AGNESE P. A. The pulmonary manifestations of fibrocystic disease of the pancreas. Dis Chest. 1955 Jun;27(6):654–667. doi: 10.1378/chest.27.6.654. [DOI] [PubMed] [Google Scholar]
  3. HUANG N. N., VAN LOON E. L., SHENG K. T. The flora of the respiratory tract of patients with cystic fibrosis of the pancreas. J Pediatr. 1961 Oct;59:512–521. doi: 10.1016/s0022-3476(61)80234-5. [DOI] [PubMed] [Google Scholar]
  4. Harrison T. G., Taylor A. G. Diagnosis of Legionella pneumophila infections by means of formolised yolk sac antigens. J Clin Pathol. 1982 Feb;35(2):211–214. doi: 10.1136/jcp.35.2.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Henderson F. W., Collier A. M., Clyde W. A., Jr, Denny F. W. Respiratory-syncytial-virus infections, reinfections and immunity. A prospective, longitudinal study in young children. N Engl J Med. 1979 Mar 8;300(10):530–534. doi: 10.1056/NEJM197903083001004. [DOI] [PubMed] [Google Scholar]
  6. Hernandez F. J., Kirby B. D., Stanley T. M., Edelstein P. H. Legionnaires' disease. Postmortem pathologic findings of 20 cases. Am J Clin Pathol. 1980 Apr;73(4):488–495. doi: 10.1093/ajcp/73.4.488. [DOI] [PubMed] [Google Scholar]
  7. Holt S., Ryan W. F., Epstein E. J. Severe mycoplasma pneumonia. Thorax. 1977 Feb;32(1):112–115. doi: 10.1136/thx.32.1.112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. May J. R., Herrick N. C., Thompson D. Bacterial infection in cystic fibrosis. Arch Dis Child. 1972 Dec;47(256):908–913. doi: 10.1136/adc.47.256.908. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nelson L. A., Callerame M. L., Schwartz R. H. Aspergillosis and atopy in cystic fibrosis. Am Rev Respir Dis. 1979 Oct;120(4):863–873. doi: 10.1164/arrd.1979.120.4.863. [DOI] [PubMed] [Google Scholar]
  10. Saravolatz L. D., Burch K. H., Fisher E., Madhavan T., Kiani D., Neblett T., Quinn E. L. The compromised host and Legionnaires' disease. Ann Intern Med. 1979 Apr;90(4):533–537. doi: 10.7326/0003-4819-90-4-533. [DOI] [PubMed] [Google Scholar]
  11. Swartz M. N. Clinical aspects of Legionnaires' disease. Ann Intern Med. 1979 Apr;90(4):492–495. doi: 10.7326/0003-4819-90-4-492. [DOI] [PubMed] [Google Scholar]
  12. Taylor A. G., Harrison T. G., Andrews B. E., Sillis M. Serological differentiation of Legionnaires' Disease and Mycoplasma pneumoniae pneumonia. Lancet. 1980 Apr 5;1(8171):764–764. doi: 10.1016/s0140-6736(80)91254-4. [DOI] [PubMed] [Google Scholar]
  13. Taylor A. G., Harrison T. G., Dighero M. W., Bradstreet C. M. False positive reactions in the indirect fluorescent antibody test for Legionnaires' disease eliminated by use of formolised yolk-sac antigen. Ann Intern Med. 1979 Apr;90(4):686–689. doi: 10.7326/0003-4819-90-4-686. [DOI] [PubMed] [Google Scholar]
  14. Wright P. F., Khaw K. T., Oxman M. N., Shwachman H. Evaluation of the safety of amantadine-HC1 and the role of respiratory viral infections in children with cystic fibrosis. J Infect Dis. 1976 Aug;134(2):144–149. doi: 10.1093/infdis/134.2.144. [DOI] [PubMed] [Google Scholar]

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