Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1984 Apr;39(4):272–276. doi: 10.1136/thx.39.4.272

Assessment of the clinical usefulness of nebulised ipratropium bromide in patients with chronic airflow limitation.

I G Brown, C S Chan, C A Kelly, A G Dent, P V Zimmerman
PMCID: PMC459782  PMID: 6232724

Abstract

The effect of adding nebulised ipratropium bromide to bronchodilator treatment was studied in 20 patients with severe chronic airflow limitation. Maintenance theophylline with or without a steroid preparation was continued and comparison made between placebo, nebulised salbutamol, and a combination of nebulised salbutamol and ipratropium. Although the mean FEV1 values showed the combination to produce a small but significant increase in peak bronchodilatation over the effect of salbutamol alone, there were eight patients in whom no clinically useful improvement occurred. The remaining 12 patients did obtain clinically useful improvement in the magnitude or the duration of bronchodilatation (or both) as a result of the added ipratropium. The conclusion is that individual patients with chronic airflow limitation responded to the addition of nebulised ipratropium bromide in a variable way. Patients who could obtain additional benefit from ipratropium need to be identified by an appropriate reversibility study before its inclusion in their bronchodilator treatment.

Full text

PDF
272

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baigelman W., Chodosh S. Bronchodilator action of the anticholinergic drug, ipratropium bromide (Sch 1000), as an aerosol in chronic bronchitis and asthma. Chest. 1977 Mar;71(3):324–328. doi: 10.1378/chest.71.3.324. [DOI] [PubMed] [Google Scholar]
  2. Connolly C. K. Adverse reaction to ipratropium bromide. Br Med J (Clin Res Ed) 1982 Oct 2;285(6346):934–935. doi: 10.1136/bmj.285.6346.934. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Douglas N. J., Davidson I., Sudlow M. F., Flenley D. C. Bronchodilatation and the site of airway resistance in severe chronic bronchitis. Thorax. 1979 Feb;34(1):51–56. doi: 10.1136/thx.34.1.51. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Leitch A. G., Hopkin J. M., Ellis D. A., Merchant S., McHardy G. J. The effect of aerosol ipratropium bromide and salbutamol on exercise tolerance in chronic bronchitis. Thorax. 1978 Dec;33(6):711–713. doi: 10.1136/thx.33.6.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lightbody I. M., Ingram C. G., Legge J. S., Johnston R. N. Ipratropium bromide, salbutamol and prednisolone in bronchial asthma and chronic bronchitis. Br J Dis Chest. 1978 Jul;72(3):181–186. doi: 10.1016/0007-0971(78)90039-6. [DOI] [PubMed] [Google Scholar]
  6. Marlin G. E., Berend N., Harrison A. C. Combined cholinergic antagonist and beta 2-adrenoceptor agonist bronchodilator therapy by inhalation. Aust N Z J Med. 1979 Oct;9(5):511–514. doi: 10.1111/j.1445-5994.1979.tb03386.x. [DOI] [PubMed] [Google Scholar]
  7. Marlin G. E., Bush D. E., Berend N. Comparison of ipratropium bromide and fenoterol in asthma and chronic bronchitis. Br J Clin Pharmacol. 1978 Dec;6(6):547–549. doi: 10.1111/j.1365-2125.1978.tb00885.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pak C. C., Kradjan W. A., Lakshminarayan S., Marini J. J. Inhaled atropine sulfate: dose-response characteristics in adult patients with chronic airflow obstruction. Am Rev Respir Dis. 1982 Mar;125(3):331–334. doi: 10.1164/arrd.1982.125.3.331. [DOI] [PubMed] [Google Scholar]
  9. Pakes G. E., Brogden R. N., Heel R. C., Speight T. M., Avery G. S. Ipratropium bromide: a review of its pharmacological properties and therapeutic efficacy in asthma and chronic bronchitis. Drugs. 1980 Oct;20(4):237–266. doi: 10.2165/00003495-198020040-00001. [DOI] [PubMed] [Google Scholar]
  10. Petrie G. R., Palmer K. N. Comparison of aerosol ipratropium bromide and salbutamol in chronic bronchitis and asthma. Br Med J. 1975 Feb 22;1(5955):430–432. doi: 10.1136/bmj.1.5955.430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ruffin R. E., Fitzgerald J. D., Rebuck A. S. A comparison of the bronchodilator activity of Sch 1000 and salbutamol. J Allergy Clin Immunol. 1977 Feb;59(2):136–141. doi: 10.1016/0091-6749(77)90215-9. [DOI] [PubMed] [Google Scholar]
  12. Ruffin R. E., Wolff R. K., Dolovich M. B., Rossman C. M., Fitzgerald J. D., Newhouse M. T. Aerosol therapy with Sch 1000. Short-term mucociliary clearance in normal and bronchitic subjects and toxicology in normal subjects. Chest. 1978 Apr;73(4):501–506. doi: 10.1378/chest.73.4.501. [DOI] [PubMed] [Google Scholar]
  13. Ward M. J., Fentem P. H., Smith W. H., Davies D. Ipratropium bromide in acute asthma. Br Med J (Clin Res Ed) 1981 Feb 21;282(6264):598–600. doi: 10.1136/bmj.282.6264.598. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES