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. 1984 Jun;39(6):457–461. doi: 10.1136/thx.39.6.457

Intimal thickening in autogenous vein grafts in rabbits: influence of aspirin and dipyridamole.

A J Murday, A H Gershlick, Y D Syndercombe-Court, P G Mills, C T Lewis
PMCID: PMC459830  PMID: 6463916

Abstract

The effects of three different platelet modifying regimens on the degree of intimal thickening of autogenous vein grafts in rabbits were measured one month after operation. Dipyridamole alone (2 mg/kg/6 h) had little effect on the intimal thickness of these rabbits compared with that of controls (mean (1 SEM) for treated animals: 72.0 (7.9) micron; controls: 63.6 (6.0) micron). High dose acetylsalicylic acid (40 mg/kg/24 h) plus dipyridamole (2 mg/kg/6 h) increased intimal thickening significantly (85.8 (6.0) v 63.6 (6.2) micron; p = 0.05, n = 17). Low dose acetylsalicylic acid (0.5 mg/kg/24 h) plus dipyridamole (2 mg/kg/6 h) also increased intimal thickening (79.0 (6.1) v 63.6 (6.0] micron but not to a significant degree. It has previously been shown in vitro that acetylsalicylic acid increases the area of an exposed subendothelial arterial surface covered by platelets. Such an effect may explain our finding of increased intimal thickening with high dose acetylsalicylic acid plus dipyridamole.

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Selected References

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  1. BOLLACK C., BRIOT B., FONTAINE R., WINISDOERFFER B., WOLF E. Des modifications structurales de l'endothélium veineux sous l'effet de diverses agressions. Lyon Chir. 1956;52:229–241. [PubMed] [Google Scholar]
  2. Baumann F. G., Catinella F. P., Cunningham J. N., Jr, Spencer F. C. Vein contraction and smooth muscle cell extensions as causes of endothelial damage during graft preparation. Ann Surg. 1981 Aug;194(2):199–211. doi: 10.1097/00000658-198108000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baumgartner H. R., Haudenschild C. Adhesion of platelets to subendothelium. Ann N Y Acad Sci. 1972 Oct 27;201:22–36. doi: 10.1111/j.1749-6632.1972.tb16285.x. [DOI] [PubMed] [Google Scholar]
  4. Baumgartner H. R., Tschopp T. B., Weiss H. J. Platelet interaction with collagen fibrils in flowing blood. II. Impaired adhesion-aggregation in bleeding disorders. A comparison with subendothelium. Thromb Haemost. 1977 Feb 28;37(1):17–28. [PubMed] [Google Scholar]
  5. Burch J. W., Stanford N., Majerus P. W. Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest. 1978 Feb;61(2):314–319. doi: 10.1172/JCI108941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cazenave J. P., Kinlough-Rathbone R. L., Packham M. A., Mustard J. F. The effect of acetylsalicylic acid and indomethacin on rabbit platelet adherence to collagen and the subendothelium in the presence of a low or high hematocrit. Thromb Res. 1978 Dec;13(6):971–981. doi: 10.1016/0049-3848(78)90226-8. [DOI] [PubMed] [Google Scholar]
  7. Chesebro J. H., Clements I. P., Fuster V., Elveback L. R., Smith H. C., Bardsley W. T., Frye R. L., Holmes D. R., Jr, Vlietstra R. E., Pluth J. R. A platelet-inhibitor-drug trial in coronary-artery bypass operations: benefit of perioperative dipyridamole and aspirin therapy on early postoperative vein-graft patency. N Engl J Med. 1982 Jul 8;307(2):73–78. doi: 10.1056/NEJM198207083070201. [DOI] [PubMed] [Google Scholar]
  8. Hanley S. P., Bevan J., Cockbill S. R., Heptinstall S. Differential inhibition by low-dose aspirin of human venous prostacyclin synthesis and platelet thromboxane synthesis. Lancet. 1981 May 2;1(8227):969–971. doi: 10.1016/s0140-6736(81)91733-5. [DOI] [PubMed] [Google Scholar]
  9. LiCalzi L. K., Stansel H. C., Jr Failure of autogenous reversed saphenous vein femoropopliteal grafting: pathophysiology and prevention. Surgery. 1982 Mar;91(3):352–358. [PubMed] [Google Scholar]
  10. McCann R. L., Hagen P. O., Fuchs J. C. Aspirin and dipyridamole decrease intimal hyperplasia in experimental vein grafts. Ann Surg. 1980 Feb;191(2):238–243. doi: 10.1097/00000658-198002000-00018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Metke M. P., Lie J. T., Fuster V., Josa M., Kaye M. P. Reduction of intimal thickening in canine coronary bypass vein grafts with dipyridamole and aspirin. Am J Cardiol. 1979 Jun;43(6):1144–1148. doi: 10.1016/0002-9149(79)90145-0. [DOI] [PubMed] [Google Scholar]
  12. Moncada S., Gryglewski R., Bunting S., Vane J. R. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature. 1976 Oct 21;263(5579):663–665. doi: 10.1038/263663a0. [DOI] [PubMed] [Google Scholar]
  13. Moncada S., Higgs E. A., Vane J. R. Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation. Lancet. 1977 Jan 1;1(8001):18–20. doi: 10.1016/s0140-6736(77)91655-5. [DOI] [PubMed] [Google Scholar]
  14. Murday A. J., Gershlick A. H., Syndercombe-Court Y. D., Ledingham S. J., Betts N. J., Lewis C. T., Mills P. G. Intimal hyperplasia in arterial autogenous vein grafts: a new animal model. Cardiovasc Res. 1983 Aug;17(8):446–451. doi: 10.1093/cvr/17.8.446. [DOI] [PubMed] [Google Scholar]
  15. Ramírez C. A., Stemerman M. B., Isaacson K. A., Colton C. K., Smith K. A., Lees R. S. Morphological and morphometric characterization of platelet adhesion to the exposed subendothelium of the rabbit thoracic aorta in vivo. Microvasc Res. 1981 May;21(3):320–331. doi: 10.1016/0026-2862(81)90015-7. [DOI] [PubMed] [Google Scholar]
  16. Ross R., Glomset J., Kariya B., Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1207–1210. doi: 10.1073/pnas.71.4.1207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Roth G. J., Majerus P. W. The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein. J Clin Invest. 1975 Sep;56(3):624–632. doi: 10.1172/JCI108132. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rutherford R. B., Ross R. Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate. J Cell Biol. 1976 Apr;69(1):196–203. doi: 10.1083/jcb.69.1.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wyatt A. P., Taylor G. W. Vein grafts: changes in the endothelium of autogenous free vein grafts used as arterial replacements. Br J Surg. 1966 Nov;53(11):943–947. doi: 10.1002/bjs.1800531107. [DOI] [PubMed] [Google Scholar]

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