Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1984 Jul;39(7):500–504. doi: 10.1136/thx.39.7.500

Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.

N C Barnes, P J Piper, J F Costello
PMCID: PMC459849  PMID: 6463929

Abstract

The comparative actions of inhaled leukotriene C4 (LTC4), leukotriene D4 (LTD4), and histamine were studied in six normal subjects. LTC4 and LTD4 were shown to be more potent bronchoconstrictors than histamine, with a more sustained action. LTC4 and LTD4 caused wheezing without cough or throat irritation and were shown to act on large and small airways.

Full text

PDF
500

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bouhuys A., Hunt V. R., Kim B. M., Zapletal A. Maximum expiratory flow rates in induced bronchoconstriction in man. J Clin Invest. 1969 Jun;48(6):1159–1168. doi: 10.1172/JCI106073. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DUBOIS A. B., BOTELHO S. Y., COMROE J. H., Jr A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest. 1956 Mar;35(3):327–335. doi: 10.1172/JCI103282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dahlén S. E., Hedqvist P., Hammarström S., Samuelsson B. Leukotrienes are potent constrictors of human bronchi. Nature. 1980 Dec 4;288(5790):484–486. doi: 10.1038/288484a0. [DOI] [PubMed] [Google Scholar]
  4. Drazen J. M., Austen K. F. Effects of intravenous administration of slow-reacting substance of anaphylaxis, histamine, bradykinin, and prostaglandin F2alpha on pulmonary mechanics in the guinea pig. J Clin Invest. 1974 Jun;53(6):1679–1685. doi: 10.1172/JCI107719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Drazen J. M., Austen K. F., Lewis R. A., Clark D. A., Goto G., Marfat A., Corey E. J. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4354–4358. doi: 10.1073/pnas.77.7.4354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Griffin M., Weiss J. W., Leitch A. G., McFadden E. R., Jr, Corey E. J., Austen K. F., Drazen J. M. Effects of leukotriene D on the airways in asthma. N Engl J Med. 1983 Feb 24;308(8):436–439. doi: 10.1056/NEJM198302243080807. [DOI] [PubMed] [Google Scholar]
  7. Holroyde M. C., Altounyan R. E., Cole M., Dixon M., Elliott E. V. Bronchoconstriction produced in man by leukotrienes C and D. Lancet. 1981 Jul 4;2(8236):17–18. doi: 10.1016/s0140-6736(81)90254-3. [DOI] [PubMed] [Google Scholar]
  8. Ingram R. H., Jr, McFadden E. R., Jr Localization and mechanisms of airway responses. N Engl J Med. 1977 Sep 15;297(11):596–600. doi: 10.1056/NEJM197709152971108. [DOI] [PubMed] [Google Scholar]
  9. Lewis R. A., Austen K. F., Drazen J. M., Clark D. A., Marfat A., Corey E. J. Slow reacting substances of anaphylaxis: identification of leukotrienes C-1 and D from human and rat sources. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3710–3714. doi: 10.1073/pnas.77.6.3710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lewis R. A., Drazen J. M., Austen K. F., Clark D. A., Corey E. J. Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity. Biochem Biophys Res Commun. 1980 Sep 16;96(1):271–277. doi: 10.1016/0006-291x(80)91210-3. [DOI] [PubMed] [Google Scholar]
  11. Mead J., Turner J. M., Macklem P. T., Little J. B. Significance of the relationship between lung recoil and maximum expiratory flow. J Appl Physiol. 1967 Jan;22(1):95–108. doi: 10.1152/jappl.1967.22.1.95. [DOI] [PubMed] [Google Scholar]
  12. Morris H. R., Piper P. J., Taylor G. W., Tippins J. R. Comparative studies on immunologically and non-immunologically produced slow-reacting substances from man, guinea-pig and rat. Br J Pharmacol. 1979 Oct;67(2):179–184. doi: 10.1111/j.1476-5381.1979.tb08664.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Morris H. R., Taylor G. W., Piper P. J., Tippins J. R. Structure of slow-reacting substance of anaphylaxis from guinea-pig lung. Nature. 1980 May 8;285(5760):104–106. doi: 10.1038/285104a0. [DOI] [PubMed] [Google Scholar]
  14. Pride N. B. Assessment of changes in airway calibre I. Tests of forced expiration. Br J Clin Pharmacol. 1979 Sep;8(3):193–203. doi: 10.1111/j.1365-2125.1979.tb01002.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pride N. B. The assessment of airflow obstruction. Role of measurements of airways resistance and of tests of forced expiration. Br J Dis Chest. 1971 Jul;65:135–169. doi: 10.1016/0007-0971(71)90018-0. [DOI] [PubMed] [Google Scholar]
  16. Ryan G., Dolovich M. B., Roberts R. S., Frith P. A., Juniper E. F., Hargreave F. E., Newhouse M. T. Standardization of inhalation provocation tests: two techniques of aerosol generation and inhalation compared. Am Rev Respir Dis. 1981 Feb;123(2):195–199. doi: 10.1164/arrd.1981.123.2.195. [DOI] [PubMed] [Google Scholar]
  17. Sirois P., Roy S., Tétrault J. P., Borgeat P., Picard S., Corey E. J. Pharmacological activity of leukotrienes A4, B4, C4 and D4 on selected guinea-pig, rat, rabbit and human smooth muscles. Prostaglandins Med. 1981 Oct;7(4):327–340. doi: 10.1016/0161-4630(81)90137-3. [DOI] [PubMed] [Google Scholar]
  18. Weichman B. M., Muccitelli R. M., Osborn R. R., Holden D. A., Gleason J. G., Wasserman M. A. In vitro and in vivo mechanisms of leukotriene-mediated bronchoconstriction in the guinea pig. J Pharmacol Exp Ther. 1982 Jul;222(1):202–208. [PubMed] [Google Scholar]
  19. Weiss J. W., Drazen J. M., Coles N., McFadden E. R., Jr, Weller P. F., Corey E. J., Lewis R. A., Austen K. F. Bronchoconstrictor effects of leukotriene C in humans. Science. 1982 Apr 9;216(4542):196–198. doi: 10.1126/science.7063880. [DOI] [PubMed] [Google Scholar]
  20. Weiss J. W., Drazen J. M., McFadden E. R., Jr, Weller P., Corey E. J., Lewis R. A., Austen K. F. Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy. JAMA. 1983 May 27;249(20):2814–2817. [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES