Table 4.
Five amino acid residues at the receptor binding site (RBS) of HA glycoproteins for 38 human H1 strains and 23 human H3 strains and their respective receptor specificity.
| Virus strain | Subtype | 138 | 190 | 225 | 226 | 228 | α2-3 | α2-6 |
|---|---|---|---|---|---|---|---|---|
| A/Kawasaki/173/2001 | H1 | S | D | D | Q | G | − | + |
| A/Puerto Rico/8/1934 | H1 | A | E | D | Q | G | + | + |
| A/Memphis/1971 | H3 | A | E | G | L | S | + | + |
| A/Udorn/307/1972 | H3 | A | E | G | L | S | + | + |
| A/Philippines/2/1982/X-79 | H3 | T | E | G | L | S | + | + |
| A/Memphis/14/1996-M [22] | H1 | S | D | D | Q | G | − | + |
| A/New Caledorial/20/1999 [57] | H1 | S | D | D | Q | G | − | + |
| A/Oklahoma/447/2008 [58] | H1 | S | D | D | Q | G | − | + |
| A/Ohio/07/2009 [57] | H1 | A | D | D | Q | G | − | + |
| A/Texas/05/2009 [57] | H1 | A | D | D | Q | G | − | + |
| A/NewYork/18/2009 [57] | H1 | A | D | D | Q | G | − | + |
| A/South Carolina/1/1918 [59] | H1 | A | D | D | Q | G | − | + |
| A/South Carolina/1/1918 [12] | H1 | A | D | D | Q | G | − | + |
| A/South Carolina/1/1918 [56] | H1 | A | D | D | Q | G | − | + |
| A/South Carolina/1/1918 (D225G) [56] | H1 | A | D | G | Q | G | + | + |
| A/California/4/2009 [56] | H1 | A | D | D | Q | G | − | + |
| A/California/4/2009 (D225E) [56] | H1 | A | D | E | Q | G | − | + |
| A/California/4/2009 (D225G) [56] | H1 | A | D | G | Q | G | + | + |
| A/California/4/2009 [22] | H1 | A | D | D | Q | G | + | + |
| A/California/07/2009 [23] | H1 | A | D | D | Q | G | + | + |
| A/California/07/2009 [60] | H1 | A | D | D | Q | G | − | + |
| A/Brisbane/59/2007 [23] | H1 | S | N | D | Q | G | + | + |
| A/Hamburg/5/2009 [22] | H1 | A | D | D | Q | G | + | + |
| A/Iowa/1/2006 [22] | H1 | A | D | N | Q | G | + | + |
| A/Mexico/Indre/4114/2009 [57] | H1 | A | D | G | Q | G | + | + |
| A/New Jersey/1976 [22] | H1 | A | D | G | Q | G | + | + |
| A/New Jersey/1976 [57] | H1 | A | D | G | Q | G | + | + |
| A/New York/1/1918 [59] | H1 | A | D | G | Q | G | + | + |
| A/New York/1/1918 [12] | H1 | A | D | G | Q | G | + | + |
| A/New York/1/1918(D190E) [12] | H1 | A | E | G | Q | G | + | − |
| A/New York/4/2009 [57] | H1 | A | D | G | Q | G | + | + |
| A/Texas/36/1991 [12] | H1 | S | D | D | Q | G | + | + |
| A/Puerto Rico/8/1934 [50] | H1 | A | E | D | Q | G | + | + |
| A/Puerto Rico/8/1934 [15] | H1 | A | E | D | Q | G | + | + |
| A/Fort Monmouth/1/1947 [15] | H1 | A | D | G | Q | G | + | + |
| A/Roma/1/1949 [15] | H1 | A | D | G | Q | G | + | + |
| A/Malaya/302/1954 [15] | H1 | A | D | G | Q | G | − | + |
| A/Denver/1957 [15] | H1 | A | E | D | Q | G | + | − |
| A/New Jersey /8/1976 [15] | H1 | A | D | G | Q | G | − | + |
| A/USSR/90/1977 [15] | H1 | S | D | G | Q | G | − | + |
| A/Brazil/11/1978 [15] | H1 | S | D | G | Q | G | − | + |
| A/India/6263/1980 [15] | H1 | S | N | D | Q | G | − | + |
| A/Chile/1/1983 [15] | H1 | A | D | N | Q | G | − | + |
| A/Taiwan/1/1986 [15] | H1 | S | D | G | Q | G | − | + |
| A/Memphis/12/1986 [15] | H1 | S | D | G | Q | G | − | + |
| A/CHR/157/1983 [15] | H1 | S | D | D | Q | G | − | + |
| A/Kawasaki/173/2001 [51] | H1 | S | D | D | Q | G | − | + |
| A/Kawasaki/173/2001 [8] | H1 | S | D | D | Q | G | − | + |
| A/Aichi/2/1968 [46] | H3 | A | E | G | L | S | + | + |
| A/Aichi/2/1968 [61] | H3 | A | E | G | L | S | + | + |
| A/Memphis/102/1972 [46] | H3 | A | E | G | L | S | + | + |
| A/LosAngeles/2/1987 [46] | H3 | A | E | G | L | S | + | + |
| A/Udorn/307/1972 [61] | H3 | A | E | G | L | S | + | + |
| A/Philippines/2/1982/X-79 [17] | H3 | A | E | G | I | S | + | + |
| A/Victoria/3/1975 [61] | H3 | A | E | G | L | S | + | + |
| A/Shanghai/11/1989 [46] | H3 | A | E | G | L | S | + | + |
| A/Udorn/307/1972 [46] | H3 | A | E | G | L | S | + | + |
| A/Udorn/307/1972 [17] | H3 | A | E | G | L | S | + | + |
| A/Udorn/307/1972(E190D) [45] | H3 | A | D | G | L | S | − | + |
| A/Hongkong/1/1968 [60] | H3 | A | E | G | L | S | − | + |
| A/Texas/1/1977 [61] | H3 | A | E | G | L | S | − | + |
| A/Shanghai/31/1980 [61] | H3 | A | E | G | L | S | − | + |
| A/LosAngeles/2/1987 [61] | H3 | A | E | G | L | S | − | + |
| A/Oklahoma/483/2008 [58] | H3 | A | D | D | I | S | − | + |
| A/Oklahoma/323/2003 [17] | H3 | A | D | D | I | S | − | + |
| A/Oklahoma/369/2005 [17] | H3 | S | D | D | I | S | − | + |
| A/Oklahoma/1992/2005 [17] | H3 | A | D | D | I | S | − | + |
| A/Tottori/872K4/1994 [62] | H3 | A | D | G | L | S | − | + |
| A/Tottori/872AM2/1994 [62] | H3 | A | D | G | L | S | − | + |
| A/Tottori/872AM4/1994 [62] | H3 | A | D | G | Q | S | + | − |
| A/Tottori/872AM1AL3/1994 [62] | H3 | A | D | G | Q | S | + | − |
| A/Tottori/872AM2AL3/1994 [62] | H3 | A | D | G | Q | S | + | − |
| A/Mem/1/71-Bel42 [47] | H3 | A | E | G | L | S | + | + |