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Schematic representation of how CaMKIIγ regulates Oct4 expression in lung cancer cells. CaMKIIγ enhances Oct4 expression depending on the increase of histone acetylation, which is mediated by acetylation transferases, especially for PCAF. Besides, Akt, activated by CaMKIIγ, is involved in this epigenetic regulation, which can be suppressed by Akt inhibitor.
