Abstract
Pulmonary and systemic blood flow and pulmonary vascular resistance were measured in 21 children with congenital heart disease. Blood flow was calculated by the direct Fick method, using measurements of metabolic gas exchange obtained by remote respiratory mass spectrometry. The observations showed that the administration of oxygen caused an appreciable fall in pulmonary vascular resistance in 16 of the 21 children studied and that this fall would not have been appreciated from a study of pulmonary arterial pressure alone as it was masked by a corresponding rise in blood flow. In 10 of 14 children, in whom superior vena caval blood was also sampled, the rise in flow was largely due to an increase in intracardiac left to right shunt. It was accompanied by widening of the alveolar-arterial oxygen gradient, perhaps due to imperfect gas equilibration within the lung.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baum D., Brown A. C., Church S. C. Effect of sedation on oxygen consumption of children undergoing cardiac catheterization. Pediatrics. 1967 Jun;39(6):891–895. [PubMed] [Google Scholar]
- Davies N. J., Denison D. M. The measurement of metabolic gas exchange and minute volume by mass spectrometry alone. Respir Physiol. 1979 Feb;36(2):261–267. doi: 10.1016/0034-5687(79)90029-x. [DOI] [PubMed] [Google Scholar]
- Davies N. J., Denison D. M. The uses of long sampling probes in respiratory mass spectrometry. Respir Physiol. 1979 Aug;37(3):335–346. doi: 10.1016/0034-5687(79)90080-x. [DOI] [PubMed] [Google Scholar]
- Fixler D. E., Carrell T., Browne R., Willis K., Miller W. W. Oxygen consumption in infants and children during cardiac catheterization under different sedation regimens. Circulation. 1974 Oct;50(4):788–794. doi: 10.1161/01.cir.50.4.788. [DOI] [PubMed] [Google Scholar]
- Honey M., Cotter L., Davies N., Denison D. Clinical and haemodynamic effects of diazoxide in primary pulmonary hypertension. Thorax. 1980 Apr;35(4):269–276. doi: 10.1136/thx.35.4.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ILIFF A., LEE V. A. The energy metabolism of infants and young children during postprandial sleep. Pediatrics. 1956 Nov;18(5):739–749. [PubMed] [Google Scholar]
- Kelman G. R. Digital computer subroutine for the conversion of oxygen tension into saturation. J Appl Physiol. 1966 Jul;21(4):1375–1376. doi: 10.1152/jappl.1966.21.4.1375. [DOI] [PubMed] [Google Scholar]
- Peacock A., Busst C., Dawkins K., Denison D. M. Response of pulmonary circulation to oral pirbuterol in chronic airflow obstruction. Br Med J (Clin Res Ed) 1983 Oct 22;287(6400):1178–1180. doi: 10.1136/bmj.287.6400.1178. [DOI] [PMC free article] [PubMed] [Google Scholar]