Abstract
Seven patients with the severe obstructive sleep apnoea syndrome were treated with nasal continuous positive airway pressure for from three to 22 months. This treatment reversed all symptoms due to the syndrome in every patient and continued to be used in five patients. One patient stopped treatment after eight months and subsequently remained incapacitated and another underwent tracheostomy at the time of transphenoidal hypophysectomy. Nasal continuous positive airway pressure is a safe, non-invasive treatment, which may be used in the presence of cardiac and respiratory failure. It is able fully to reverse upper airway obstruction and can be used at home on a long term basis.
Full text
PDF





Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brownell L. G., West P., Sweatman P., Acres J. C., Kryger M. H. Protriptyline in obstructive sleep apnea: a double-blind trial. N Engl J Med. 1982 Oct 21;307(17):1037–1042. doi: 10.1056/NEJM198210213071701. [DOI] [PubMed] [Google Scholar]
- Cartwright R. D., Samelson C. F. The effects of a nonsurgical treatment for obstructive sleep apnea. The tongue-retaining device. JAMA. 1982 Aug 13;248(6):705–709. [PubMed] [Google Scholar]
- Coleman R. M., Roffwarg H. P., Kennedy S. J., Guilleminault C., Cinque J., Cohn M. A., Karacan I., Kupfer D. J., Lemmi H., Miles L. E. Sleep-wake disorders based on a polysomnographic diagnosis. A national cooperative study. JAMA. 1982 Feb 19;247(7):997–1003. [PubMed] [Google Scholar]
- Guilleminault C., Simmons F. B., Motta J., Cummiskey J., Rosekind M., Schroeder J. S., Dement W. C. Obstructive sleep apnea syndrome and tracheostomy. Long-term follow-up experience. Arch Intern Med. 1981 Jul;141(8):985–988. [PubMed] [Google Scholar]
- Miller W. P. Cardiac arrhythmias and conduction disturbances in the sleep apnea syndrome. Prevalence and significance. Am J Med. 1982 Sep;73(3):317–321. doi: 10.1016/0002-9343(82)90716-1. [DOI] [PubMed] [Google Scholar]
- Motta J., Guilleminault C., Schroeder J. S., Dement W. C. Tracheostomy and hemodynamic changes in sleep-inducing apnea. Ann Intern Med. 1978 Oct;89(4):454–458. doi: 10.7326/0003-4819-89-4-454. [DOI] [PubMed] [Google Scholar]
- Olsen K. D., Suh K. W., Staats B. A. Surgically correctable causes of sleep apnea syndrome. Otolaryngol Head Neck Surg. 1981 Sep-Oct;89(5):726–731. doi: 10.1177/019459988108900506. [DOI] [PubMed] [Google Scholar]
- Rapoport D. M., Sorkin B., Garay S. M., Goldring R. M. Reversal of the "Pickwickian syndrome" by long-term use of nocturnal nasal-airway pressure. N Engl J Med. 1982 Oct 7;307(15):931–933. doi: 10.1056/NEJM198210073071507. [DOI] [PubMed] [Google Scholar]
- Sullivan C. E., Berthon-Jones M., Issa F. G. Remission of severe obesity-hypoventilation syndrome after short-term treatment during sleep with nasal continuous positive airway pressure. Am Rev Respir Dis. 1983 Jul;128(1):177–181. doi: 10.1164/arrd.1983.128.1.177. [DOI] [PubMed] [Google Scholar]
- Sullivan C. E., Issa F. G., Berthon-Jones M., Eves L. Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet. 1981 Apr 18;1(8225):862–865. doi: 10.1016/s0140-6736(81)92140-1. [DOI] [PubMed] [Google Scholar]
- Wagner D. R., Pollak C. P., Weitzman E. D. Nocturnal nasal-airway pressure for sleep apnea. N Engl J Med. 1983 Feb 24;308(8):461–462. doi: 10.1056/nejm198302243080820. [DOI] [PubMed] [Google Scholar]

