Abstract
Lung function at rest was assessed in 50 patients before and six months after mitral valve surgery. There were small increases in spirometric volumes (FEV1 and vital capacity) with decreases in total lung capacity and residual volume, but no change in carbon monoxide transfer factor or transfer coefficient (KCO). Progressive exercise tests performed before and after operation in 19 of the patients confirmed an improved exercise capacity after surgery. The patients with the greatest symptomatic improvement in breathlessness were also those who achieved the greatest increase in maximum work load and the greatest decrease in ventilation for a given oxygen consumption. Depression of the ST segment of the electrocardiogram and frequent ventricular ectopic beats on exercise remained common after surgery and may have been due to digoxin treatment.
Full text
PDF





Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BERGLUND E., BIRATH G., BJURE J., GRIMBY G., KJELLMER I., SANDQVIST L., SODERHOLM B. Spirometric studies in normal subjects. I. Forced expirograms in subjects between 7 and 70 years of age. Acta Med Scand. 1963 Feb;173:185–192. [PubMed] [Google Scholar]
- BLAKEMORE W. S., FORSTER R. E., MORTON J. W., OGILVIE C. M. A standardized breath holding technique for the clinical measurement of the diffusing capacity of the lung for carbon monoxide. J Clin Invest. 1957 Jan;36(1 Pt 1):1–17. doi: 10.1172/JCI103402. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bradley J., Bye C., Hayden S. P., Hughes D. T. Normal values of transfer factor and transfer coefficients in healthy males and females. Respiration. 1979;38(4):221–226. doi: 10.1159/000194084. [DOI] [PubMed] [Google Scholar]
- CARROLL D. G., COHEN G., COHN J. E., JOHNS C. J., RILEY R. L., SHEPARD R. H. The diffusing capacity of the lungs in patients with mitral stenosis studied post-operatively. J Clin Invest. 1956 Sep;35(9):1008–1014. doi: 10.1172/JCI103346. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COSBY R. S., STOWELL E. C., Jr, HARTWIG W. R., MAYO M. Abnormal ventilatory patterns in mitral stenosis. Dis Chest. 1956 Jun;29(6):633–640. doi: 10.1378/chest.29.6.633. [DOI] [PubMed] [Google Scholar]
- CURTI P. C., COHEN G., CASTLEMAN B., SCANNELL J. G., FRIEDLICH A. L., MYERS G. S. Respiratory and circulatory studies of patients with mitral stenosis. Circulation. 1953 Dec;8(6):893–904. doi: 10.1161/01.cir.8.6.893. [DOI] [PubMed] [Google Scholar]
- Cotes J. E., Dabbs J. M., Elwood P. C., Hall A. M., McDonald A., Saunders M. J. Iron-deficiency anaemia: its effect on transfer factor for the lung (diffusiong capacity) and ventilation and cardiac frequency during sub-maximal exercise. Clin Sci. 1972 Mar;42(3):325–335. doi: 10.1042/cs0420325. [DOI] [PubMed] [Google Scholar]
- DOGLIOTTI G. C., ANGELINO P. F., BRUSCA A., GARBAGNI R., GAVOSTO F., MAGRI G., MINETTO E. Pulmonary function in mitral valve disease; hemodynamic and ventilatory studies. Am J Cardiol. 1959 Jan;3(1):28–39. doi: 10.1016/0002-9149(59)90392-3. [DOI] [PubMed] [Google Scholar]
- DUBOIS A. B., BOTELHO S. Y., BEDELL G. N., MARSHALL R., COMROE J. H., Jr A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects. J Clin Invest. 1956 Mar;35(3):322–326. doi: 10.1172/JCI103281. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GARBAGNI R., ANGELINO P. F., BRUSCA A., MINETTO E. Residual lung volume in mitral disease. Br Heart J. 1958 Oct;20(4):479–482. doi: 10.1136/hrt.20.4.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GOLDMAN H. I., BECKLAKE M. R. Respiratory function tests; normal values at median altitudes and the prediction of normal results. Am Rev Tuberc. 1959 Apr;79(4):457–467. doi: 10.1164/artpd.1959.79.4.457. [DOI] [PubMed] [Google Scholar]
- Gilmour D. G., Spiro S. G., Raphael M. J., Freedman S. Exercise tests before and after heart valve replacement. Br J Dis Chest. 1976 Jul;70(3):185–194. doi: 10.1016/0007-0971(76)90028-0. [DOI] [PubMed] [Google Scholar]
- KORY R. C., CALLAHAN R., BOREN H. G., SYNER J. C. The Veterans Administration-Army cooperative study of pulmonary function. I. Clinical spirometry in normal men. Am J Med. 1961 Feb;30:243–258. doi: 10.1016/0002-9343(61)90096-1. [DOI] [PubMed] [Google Scholar]
- MACINTOSH D. J., SINNOTT J. C., MILNE I. G., REID E. A. Some aspects of disordered pulmonary function in mitral stenosis. Ann Intern Med. 1958 Dec;49(6):1294–1304. doi: 10.7326/0003-4819-49-6-1294. [DOI] [PubMed] [Google Scholar]
- Morris S. N., Phillips J. F., Jordan J. W., McHenry P. L. Incidence and significance of decreases in systolic blood pressure during graded treadmill exercise testing. Am J Cardiol. 1978 Feb;41(2):221–226. doi: 10.1016/0002-9149(78)90160-1. [DOI] [PubMed] [Google Scholar]
- Reed J. W., Ablett M., Cotes J. E. Ventilatory responses to exercise and to carbon dioxide in mitral stenosis before and after valvulotomy: causes of tachypnoea. Clin Sci Mol Med. 1978 Jan;54(1):9–16. doi: 10.1042/cs0540009. [DOI] [PubMed] [Google Scholar]
- Rhodes K. M., Evemy K., Nariman S., Gibson G. J. Relation between severity of mitral valve disease and results of routine lung function tests in non-smokers. Thorax. 1982 Oct;37(10):751–755. doi: 10.1136/thx.37.10.751. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Singh T., Dinda P., Chatterjee S. S., Riding W. D., Patel T. K. Pulmonary function studies before and after closed mitral valvotomy. Am Rev Respir Dis. 1970 Jan;101(1):62–66. doi: 10.1164/arrd.1970.101.1.62. [DOI] [PubMed] [Google Scholar]
