Skip to main content
Thorax logoLink to Thorax
. 1985 Mar;40(3):187–190. doi: 10.1136/thx.40.3.187

Serum concentrations of vitamin D metabolites in untreated tuberculosis.

P D Davies, R C Brown, J S Woodhead
PMCID: PMC460025  PMID: 3872485

Abstract

A prospective study of 50 consecutive patients presenting with tuberculosis has shown that patients have on average lower serum concentrations of 25-hydroxycholecalciferol (25-OHD) than healthy matched controls. No difference was shown in serum 1,25-(OH)2D, 24,25-(OH)2D, or parathyroid hormone. Uncorrected serum calcium was lower in the patient group but identical when correction concentrations were made for albumin. Serum liver enzyme concentrations were significantly higher in the patient population. Low serum vitamin D concentrations may be a consequence of disease. The possibility that low serum 25-OHD concentrations may predispose to tuberculosis infection cannot, however, be excluded. Prolonged treatment with isoniazid or rifampicin, both of which have been shown to reduce serum 25-OHD, may increase the risk of vitamin D deficiency and consequent osteomalacia in groups of patients most at risk, such as those of Indian subcontinental ethnic origin.

Full text

PDF
187

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bowry S., Chan C. H., Weiss H., Katz S., Zimmerman H. J. Hepatic involvement in pulmonary tuberculosis. Histologic and functional characteristics. Am Rev Respir Dis. 1970 Jun;101(6):941–948. doi: 10.1164/arrd.1970.101.6.941. [DOI] [PubMed] [Google Scholar]
  2. Brodie M. J., Boobis A. R., Dollery C. T., Hillyard C. J., Brown D. J., MacIntyre I., Park B. K. Rifampicin and vitamin D metabolism. Clin Pharmacol Ther. 1980 Jun;27(6):810–814. doi: 10.1038/clpt.1980.115. [DOI] [PubMed] [Google Scholar]
  3. Clemens T. L., Hendy G. N., Graham R. F., Baggiolini E. G., Uskokovic M. R., O'Riordan J. L. A radioimmunoassay for 1,25-dihydroxycholecalciferol. Clin Sci Mol Med. 1978 Mar;54(3):329–332. doi: 10.1042/cs0540329. [DOI] [PubMed] [Google Scholar]
  4. DUNNIGAN M. G., PATON J. P., HAASE S., McNICOL G. W., GARDNER M. D., SMITH C. M. Late rickets and osteomalacia in the Pakistani community in Glasgow. Scott Med J. 1962 Apr;7:159–167. doi: 10.1177/003693306200700402. [DOI] [PubMed] [Google Scholar]
  5. Ford J. A., Colhoun E. M., McIntosh W. B., Dunnigan M. G. Rickets and osteomalacia in the Glasgow Pakistani community, 1961-71. Br Med J. 1972 Jun 17;2(5815):677–680. doi: 10.1136/bmj.2.5815.677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Grenville-Mathers R., Clark J. B. The development of tuberculosis in Afro-Asian immigrants. Tubercle. 1979 Mar;60(1):25–29. doi: 10.1016/0041-3879(79)90052-7. [DOI] [PubMed] [Google Scholar]
  7. Hunt S. P., O'Riordan J. L., Windo J., Truswell A. S. Vitamin D status in different subgroups of British Asians. Br Med J. 1976 Dec 4;2(6048):1351–1354. doi: 10.1136/bmj.2.6048.1351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jha V. K., Kotilingam K., Shukla P. K., Roy D. C., Joshi M. Liver function in pulmonary tuberculosis. Indian J Chest Dis. 1974 Jul;16(3):171–181. [PubMed] [Google Scholar]
  9. McCarthy D. M., Hibbin J. A., Goldman J. M. A role for 1,25-dihydroxyvitamin D3 in control of bone-marrow collagen deposition? Lancet. 1984 Jan 14;1(8368):78–80. doi: 10.1016/s0140-6736(84)90007-2. [DOI] [PubMed] [Google Scholar]
  10. Moss D. W., Whitby L. G. A simplified heat-inactivation method for investigating alkaline phosphatase isoenzymes in serum. Clin Chim Acta. 1975 May 15;61(1):63–71. doi: 10.1016/0009-8981(75)90398-8. [DOI] [PubMed] [Google Scholar]
  11. Prasad M., Tyagi S. P., Ahmad K. N., Bahadur P., Tajuddin M. Liver in pulmonary tuberculosis. Indian J Chest Dis. 1973 Jan;15(1):38–44. [PubMed] [Google Scholar]
  12. Sen P. K., Saha J. R., Chatterjee R., Dutta T. K. Liver function tests in health and tuberculosis. Indian J Med Res. 1972 May;60(5):674–682. [PubMed] [Google Scholar]
  13. Whitaker K. B., Whitby L. G., Moss D. W. Activities of bone and liver alkaline phosphatases in serum in health and disease. Clin Chim Acta. 1977 Oct 1;80(1):209–220. doi: 10.1016/0009-8981(77)90281-9. [DOI] [PubMed] [Google Scholar]
  14. Whitby L. G., Moss D. W. Analysis of heat inactivation curves of alkaline phosphatase isoenzymes in serum. Clin Chim Acta. 1975 Mar 24;59(3):361–367. doi: 10.1016/0009-8981(75)90012-1. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES