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. 1985 May;40(5):364–370. doi: 10.1136/thx.40.5.364

Changes in ventilation and its components in normal subjects during sleep.

J R Stradling, G A Chadwick, A J Frew
PMCID: PMC460068  PMID: 4023990

Abstract

Non-invasive measurements were made of ventilation, its derivatives, the contributions of abdomen and rib cage and arterial oxygen saturation in six healthy normal men whilst awake and during sleep. Minute ventilation fell significantly during slow wave (SW) sleep and rapid eye movement (REM) sleep (awake = 6.3 1 min-1, SW sleep = 5.7 1 min-1, REM sleep = 5.4 1 min-1; p less than 0.04). Mean inspiratory flow also fell significantly but timing was unchanged. The abdominal (diaphragmatic) contribution to ventilation fell very significantly during SW sleep but returned to awake levels during REM sleep (awake 54%, SW sleep 38%, REM sleep 56%; p less than 0.007). There were also significant falls in arterial oxygen saturation during SW and REM sleep (awake 97.3%, SW sleep 96.5%, REM sleep 96.2%; p less than 0.002). These falls represent reductions in arterial oxygen tension similar to those seen in patients with chronic airways obstruction and can be accounted for entirely by the associated reduction in ventilation.

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Selected References

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  1. Askanazi J., Silverberg P. A., Foster R. J., Hyman A. I., Milic-Emili J., Kinney J. M. Effects of respiratory apparatus on breathing pattern. J Appl Physiol Respir Environ Exerc Physiol. 1980 Apr;48(4):577–580. doi: 10.1152/jappl.1980.48.4.577. [DOI] [PubMed] [Google Scholar]
  2. Berthon-Jones M., Sullivan C. E. Ventilatory and arousal responses to hypoxia in sleeping humans. Am Rev Respir Dis. 1982 Jun;125(6):632–639. doi: 10.1164/arrd.1982.125.6.632. [DOI] [PubMed] [Google Scholar]
  3. Block A. J., Boysen P. G., Wynne J. W. The origins of cor pulmonale; a hypothesis. Chest. 1979 Feb;75(2):109–110. doi: 10.1378/chest.75.2.109. [DOI] [PubMed] [Google Scholar]
  4. Chapman K. R., D'Urzo A., Rebuck A. S. The accuracy and response characteristics of a simplified ear oximeter. Chest. 1983 Jun;83(6):860–864. doi: 10.1378/chest.83.6.860. [DOI] [PubMed] [Google Scholar]
  5. Douglas N. J., Calverley P. M., Leggett R. J., Brash H. M., Flenley D. C., Brezinova V. Transient hypoxaemia during sleep in chronic bronchitis and emphysema. Lancet. 1979 Jan 6;1(8106):1–4. doi: 10.1016/s0140-6736(79)90451-3. [DOI] [PubMed] [Google Scholar]
  6. Douglas N. J., White D. P., Pickett C. K., Weil J. V., Zwillich C. W. Respiration during sleep in normal man. Thorax. 1982 Nov;37(11):840–844. doi: 10.1136/thx.37.11.840. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Douglas N. J., White D. P., Weil J. V., Pickett C. K., Martin R. J., Hudgel D. W., Zwillich C. W. Hypoxic ventilatory response decreases during sleep in normal men. Am Rev Respir Dis. 1982 Mar;125(3):286–289. doi: 10.1164/arrd.1982.125.3.286. [DOI] [PubMed] [Google Scholar]
  8. Flenley D. C. Clinical hypoxia: Causes, consequences, and correction. Lancet. 1978 Mar 11;1(8063):542–546. doi: 10.1016/s0140-6736(78)90564-0. [DOI] [PubMed] [Google Scholar]
  9. Gilbert R., Auchincloss J. H., Jr, Brodsky J., Boden W. Changes in tidal volume, frequency, and ventilation induced by their measurement. J Appl Physiol. 1972 Aug;33(2):252–254. doi: 10.1152/jappl.1972.33.2.252. [DOI] [PubMed] [Google Scholar]
  10. Gilbert R., Auchincloss J. H., Jr, Peppi D. Relationship of rib cage and abdomen motion to diaphragm function during quiet breathing. Chest. 1981 Nov;80(5):607–612. doi: 10.1378/chest.80.5.607. [DOI] [PubMed] [Google Scholar]
  11. Guilleminault C., Tilkian A., Dement W. C. The sleep apnea syndromes. Annu Rev Med. 1976;27:465–484. doi: 10.1146/annurev.me.27.020176.002341. [DOI] [PubMed] [Google Scholar]
  12. Hudgel D. W., Martin R. J., Capehart M., Johnson B., Hill P. Contribution of hypoventilation to sleep oxygen desaturation in chronic obstructive pulmonary disease. J Appl Physiol Respir Environ Exerc Physiol. 1983 Sep;55(3):669–677. doi: 10.1152/jappl.1983.55.3.669. [DOI] [PubMed] [Google Scholar]
  13. Krieger J., Kurtz D. Effects of pneumotachographic recording of breathing on sleep and respiration during sleep. Bull Eur Physiopathol Respir. 1983 Nov-Dec;19(6):641–644. [PubMed] [Google Scholar]
  14. Mortola J. P., Anch A. M. Chest wall configuration in supine man: wakefulness and sleep. Respir Physiol. 1978 Nov;35(2):201–213. doi: 10.1016/0034-5687(78)90022-1. [DOI] [PubMed] [Google Scholar]
  15. Parmeggiani P. L., Sabattini L. Electromyographic aspects of postural, respiratory and thermoregulatory mechanisms in sleeping cats. Electroencephalogr Clin Neurophysiol. 1972 Jul;33(1):1–13. doi: 10.1016/0013-4694(72)90020-x. [DOI] [PubMed] [Google Scholar]
  16. Phillipson E. A. Control of breathing during sleep. Am Rev Respir Dis. 1978 Nov;118(5):909–939. doi: 10.1164/arrd.1978.118.5.909. [DOI] [PubMed] [Google Scholar]
  17. Sackner J. D., Nixon A. J., Davis B., Atkins N., Sackner M. A. Effects of breathing through external dead space on ventilation at rest and during exercise. II. Am Rev Respir Dis. 1980 Dec;122(6):933–940. doi: 10.1164/arrd.1980.122.6.933. [DOI] [PubMed] [Google Scholar]
  18. Skatrud J., Iber C., McHugh W., Rasmussen H., Nichols D. Determinants of hypoventilation during wakefulness and sleep in diaphragmatic paralysis. Am Rev Respir Dis. 1980 Mar;121(3):587–593. doi: 10.1164/arrd.1980.121.3.587. [DOI] [PubMed] [Google Scholar]
  19. Stradling J. R., Lane D. J. Nocturnal hypoxaemia in chronic obstructive pulmonary disease. Clin Sci (Lond) 1983 Feb;64(2):213–222. doi: 10.1042/cs0640213. [DOI] [PubMed] [Google Scholar]
  20. Stradling J. R., Nicholl C. G., Cover D., Davies E. E., Hughes J. M., Pride N. B. The effects of oral almitrine on pattern of breathing and gas exchange in patients with chronic obstructive pulmonary disease. Clin Sci (Lond) 1984 Apr;66(4):435–442. doi: 10.1042/cs0660435. [DOI] [PubMed] [Google Scholar]
  21. TRASK C. H., CREE E. M. Oximeter studies on patients with chronic obstructive emphysema, awake and during sleep. N Engl J Med. 1962 Mar 29;266:639–642. doi: 10.1056/NEJM196203292661303. [DOI] [PubMed] [Google Scholar]
  22. Tabachnik E., Muller N. L., Bryan A. C., Levison H. Changes in ventilation and chest wall mechanics during sleep in normal adolescents. J Appl Physiol Respir Environ Exerc Physiol. 1981 Sep;51(3):557–564. doi: 10.1152/jappl.1981.51.3.557. [DOI] [PubMed] [Google Scholar]
  23. Tobin M. J., Chadha T. S., Jenouri G., Birch S. J., Gazeroglu H. B., Sackner M. A. Breathing patterns. 2. Diseased subjects. Chest. 1983 Sep;84(3):286–294. doi: 10.1378/chest.84.3.286. [DOI] [PubMed] [Google Scholar]
  24. Tusiewicz K., Moldofsky H., Bryan A. C., Bryan M. H. Mechanics of the rib cage and diaphragm during sleep. J Appl Physiol Respir Environ Exerc Physiol. 1977 Oct;43(4):600–602. doi: 10.1152/jappl.1977.43.4.600. [DOI] [PubMed] [Google Scholar]
  25. West J. B. Ventilation-perfusion inequality and overall gas exchange in computer models of the lung. Respir Physiol. 1969 Jun;7(1):88–110. doi: 10.1016/0034-5687(69)90071-1. [DOI] [PubMed] [Google Scholar]
  26. Zimmerman P. V., Connellan S. J., Middleton H. C., Tabona M. V., Goldman M. D., Pride N. Postural changes in rib cage and abdominal volume-motion coefficients and their effect on the calibration of a respiratory inductance plethysmograph. Am Rev Respir Dis. 1983 Feb;127(2):209–214. doi: 10.1164/arrd.1983.127.2.209. [DOI] [PubMed] [Google Scholar]

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