Figure 3.
Targeting of PrPC and its partners in CSCs for cancer therapy. Conventional therapy targets tumor cells by destroying them or decreasing their proliferation. Tumor growth is governed by multiple cellular mechanisms in which PrPC plays a role. The progression of tumor development is related to the presence of cancer stem cells that have a pivotal role in cell resistance, culminating in tumor recurrence. Indeed, PrPC and its ligands in cancer stem cells could also be targeted, suggesting a promising approach for novel cancer therapies. Cells with dotted lines represent cells undergoing cell death.