Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1985 Jul;40(7):533–537. doi: 10.1136/thx.40.7.533

Ligation of patent ductus arteriosus in very low birthweight premature neonates.

P K Ghosh, J Lubliner, M Mogilnar, V Yakirevich, B A Vidne
PMCID: PMC460127  PMID: 4035621

Abstract

The results of ligation of a patent ductus arteriosus in 30 premature neonates with a very low birth weight were analysed. The mean gestational age at birth was 27 weeks and the mean weight 811 g. Attempted closure of the ductus with indomethacin in 19 infants failed, though there was temporary closure in nine. Congestive heart failure was present in 29 and respiratory distress in 22 patients. Endotracheal intubation with assisted ventilation was necessary in all cases. The mean age at operation was 13.5 days and ductal ligation was performed in the intensive care unit under local anaesthesia supplemented with pancuronium and pethidine. There were no intraoperative deaths, but five infants died in hospital. There were seven late deaths. Eighteen survivors have been followed for a mean of 26.5 months. Early ligation of a patent ductus arteriosus in premature infants with a very low birth weight improved the cardiorespiratory state. Long term follow up showed good clinical progress in two thirds of the surviving group.

Full text

PDF
533

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURNARD E. D. A murmur that may arise from the ductus arteriosus in the human baby. Proc R Soc Med. 1959 Jan;52(1):77–78. doi: 10.1177/003591575905200114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Betts E. K., Downes J. J., Schaffer D. B., Johns R. Retrolental fibroplasia and oxygen administration during general anesthesia. Anesthesiology. 1977 Dec;47(6):518–520. doi: 10.1097/00000542-197712000-00010. [DOI] [PubMed] [Google Scholar]
  3. Clarke D. R., Paton B. C., Way G. L., Stewart J. R. Patent ductus arteriosus ligation and respiratory distress syndrome in premature infants. Ann Thorac Surg. 1976 Aug;22(2):138–145. doi: 10.1016/s0003-4975(10)63974-4. [DOI] [PubMed] [Google Scholar]
  4. Coran A. G., Cabal L., Siassi B., Rosenkrantz J. G. Surgical closure of patent ductus arteriosus in the premature infant with respiratory distress. J Pediatr Surg. 1975 Jun;10(3):399–404. doi: 10.1016/0022-3468(75)90103-7. [DOI] [PubMed] [Google Scholar]
  5. Eisele J. H., Smith N. T. Cardiovascular effects of 40 percent nitrous oxide in man. Anesth Analg. 1972 Nov-Dec;51(6):956–963. [PubMed] [Google Scholar]
  6. Ellison R. C., Peckham G. J., Lang P., Talner N. S., Lerer T. J., Lin L., Dooley K. J., Nadas A. S. Evaluation of the preterm infant for patent ductus arteriosus. Pediatrics. 1983 Mar;71(3):364–372. [PubMed] [Google Scholar]
  7. Friedman W. F., Hirschklau M. J., Printz M. P., Pitlick P. T., Kirkpatrick S. E. Pharmacologic closure of patent ductus arteriosus in the premature infant. N Engl J Med. 1976 Sep 2;295(10):526–529. doi: 10.1056/NEJM197609022951003. [DOI] [PubMed] [Google Scholar]
  8. Friedman Z., Whitman V., Maisels M. J., Berman W., Jr, Marks K. H., Vesell E. S. Indomethacin disposition and indomethacin-induced platelet dysfunction in premature infants. J Clin Pharmacol. 1978 May-Jun;18(5-6):272–279. doi: 10.1002/j.1552-4604.1978.tb02446.x. [DOI] [PubMed] [Google Scholar]
  9. Gay J. H., Daily W. J., Meyer B. H., Trump D. S., Cloud D. T., Molthan M. E. Ligation of the patent ductus arteriosus in premature infants: report of 45 cases. J Pediatr Surg. 1973 Oct;8(5):677–683. doi: 10.1016/0022-3468(73)90406-5. [DOI] [PubMed] [Google Scholar]
  10. Girling D. J., Hallidie-Smith K. A. Persistant ductus arteriosus in ill and premature babies. Arch Dis Child. 1971 Apr;46(246):177–181. doi: 10.1136/adc.46.246.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hall G. S., Helmsworth J. A., Schreiber J. T., Rosenkrantz J. G., Martin L. W., Baylen B. G., Kaplan S. Premature infants with patent ductus arteriosus and respiratory distress: selection for ductal ligation. Ann Thorac Surg. 1976 Aug;22(2):146–150. doi: 10.1016/s0003-4975(10)63976-8. [DOI] [PubMed] [Google Scholar]
  12. Heymann M. A., Rudolph A. M., Silverman N. H. Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med. 1976 Sep 2;295(10):530–533. doi: 10.1056/NEJM197609022951004. [DOI] [PubMed] [Google Scholar]
  13. Kitterman J. A. Patent ductus arteriosus: current clinical status. Arch Dis Child. 1980 Feb;55(2):106–109. doi: 10.1136/adc.55.2.106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Levitsky S., Fisher E., Vidyasagar D., Hastreiter A. R., Bennett E., Raju T. N., Roper K. Interruption of patent ductus arteriosus in premature infants with respiratory distress syndrome. Ann Thorac Surg. 1976 Aug;22(2):131–137. doi: 10.1016/s0003-4975(10)63973-2. [DOI] [PubMed] [Google Scholar]
  15. Lippmann M., Nelson R. J., Emmanouilides G. C., Diskin J., Thibeault D. W. Ligation of patent ductus arteriosus in premature infants. Br J Anaesth. 1976 Apr;48(4):365–369. doi: 10.1093/bja/48.4.365. [DOI] [PubMed] [Google Scholar]
  16. Mavroudis C., Cook L. N., Fleischaker J. W., Nagaraj H. S., Shott R. J., Howe W. R., Gray L. A., Jr Management of patent ductus arteriosus in the premature infant: indomethacin versus ligation. Ann Thorac Surg. 1983 Nov;36(5):561–566. doi: 10.1016/s0003-4975(10)60686-8. [DOI] [PubMed] [Google Scholar]
  17. Mikhail M., Lee W., Toews W., Synhorst D. P., Hawes C. R., Hernandez J., Lockhart C., Whitfield J., Pappas G. Surgical and medical experience with 734 premature infants with patient ductus arteriosus. J Thorac Cardiovasc Surg. 1982 Mar;83(3):349–357. [PubMed] [Google Scholar]
  18. Neal W. A., Kyle J. M., Mullett M. D. Failure of indomethacin therapy to induce closure of patent ductus arteriosus in premature infants with respiratory distress syndrome. J Pediatr. 1977 Oct;91(4):621–623. doi: 10.1016/s0022-3476(77)80519-2. [DOI] [PubMed] [Google Scholar]
  19. Neuman G. G., Hansen D. D. The anaesthetic management of preterm infants undergoing ligation of patent ductus arteriosus. Can Anaesth Soc J. 1980 May;27(3):248–253. doi: 10.1007/BF03007435. [DOI] [PubMed] [Google Scholar]
  20. Oxnard S. C., McGough C., Jung A. L., Ruttenberg H. D. Ligation of the patent ductus arteriousus in the newborn intensive care unit. Ann Thorac Surg. 1977 Jun;23(6):564–567. doi: 10.1016/s0003-4975(10)63703-4. [DOI] [PubMed] [Google Scholar]
  21. Rittenhouse E. A. A rational approach to patent ductus arteriosus in the neonate. Chest. 1979 Jun;75(6):652–653. doi: 10.1378/chest.75.6.652. [DOI] [PubMed] [Google Scholar]
  22. Salomon N. W., Anderson R. M., Copeland J. G., Allen H. D., Goldberg S. J., Sahn D. J. A rational approach to ligation of patent ductus arteriosus in the neonate. Chest. 1979 Jun;75(6):671–674. doi: 10.1378/chest.75.6.671. [DOI] [PubMed] [Google Scholar]
  23. Scarano V. R. Ligation of patent ductus arteriosus in the neonate. Chest. 1980 Feb;77(2):248–248. doi: 10.1378/chest.77.2.248-a. [DOI] [PubMed] [Google Scholar]
  24. Siassi B., Blanco C., Cabal L. A., Coran A. G. Incidence and clinical features of patent ductus arteriosus in low-birthweight infants: a prospective analysis of 150 consecutively born infants. Pediatrics. 1976 Mar;57(3):347–351. [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES