Table 1.
Observed behavioral abnormalities in Prnp0/0 mouse lines with different genetic backgrounds
| Author and year | Mouse line and age | Behavior tests | Behavioral abnormalities |
|---|---|---|---|
| Bueler et al., 19922 | Zrch I, 129/Sv×C57BL/6J, (7 months) | 2-way avoidance, water maze | no abnormalities |
| Manson et 19941 | Edingb., 129OLA, (7 months) | researcher observation | no abnormalities |
| Tobler et al., 19979 | Zrch I, 129/Sv×C57BL/6J, (3 months) | Vigilance state, EEG, EMG | deficits in sleep regulation |
| Lipp et al., 199811 | Zrch I,129/Sv×C57BL/6J, backcrossed (24 months) | water maze | no abnormalities |
| Roesler et al., 199919 | Zrch I, 129/Sv×C57BL/6J, (3 months) | OF, EPM, step-down inhibitory avoidance task | slightly increased locomotor activity |
| Coitinho et al., 200314 | Zrch I, 129/Sv×C57BL/6J, (3 and 9 months) | step-down inhibitory avoidance task, OF | impairment of short- and long-term memory, decreased locomotor activity during exploration |
| Criado et al., 200515 | Edingb., homogeneous 129/Ola background and 129/Ola C57BL/10, (backcrossed) | barnes circular maze | increased latency to initiate exploration, deficits in spatial learning |
| Nico et al., 2005a,b17,35 | Zrch I, 129/Sv×C57BL/6J, (3 months) | EPM, OF, swim-test | decreased anxiety and locomotion after acute stress, sensitive to stress, impairment of swimming capacity |
| Lobão-Soares et al., 200736, 200818 | Zrch I, 129/Sv×C57BL/6J, (3 months) | EPM, OF, rota-rod, tropical snake, olfactory discrimination task, defensive attention and risk assessment | less anxiety, reduced duration of grooming, decrease in the attentional defensive response |
| Meotti et al., 200737 | Zrch I, 129/Sv×C57BL/6J, (3 months) | thermal and chemical models of nociception | nociceptive response, more resistant than wild-type mice to thermal nociception |
| Le Pichon et al., 200938 | Zrch I, 129/Sv×C57BL/6J and Edingb. 129/OLA, Ngsk C57BL/6J | cookie finding test | olfactory deficits |
| Rial et al., 200913 | Zrch I, 129/Sv×C57BL/6J (3 and 11 months) | EPM, OF, social recognition, step-down inhibitory avoidance task | less anxiety, decreased locomotor activity, deficits in social recognition |
| Gadotti et al., 201224 | Zrch I C57BL/6J, (2.5 months) | OF, FST, TST | more depressive |
| Schmitz et al., 201412 | Zrch I, 129/Sv×C57BL/6J (3, 9 and 20 months) | OF, NOR, EPM, FC, nest building, rota-rod | cognitive and associated learning deficits, fearlessness during aging, impaired nesting and increased latency to explore a new environment |
| Tomaz et al., 201425 | Zrch I, C57BL6J, (3 months) | offensive aggressive behavior test | increased aggressive behavior |