Table 2. Significant Protein Fold Change: Mouse Brain FU-CJD PK+ compared to Normal PK+.

N	Protein	Uniprot ID	Protein Name	Gene Name	log2fc	Fold-change	SE	adj_pvalue
1	P63017	HSP7C_MOUSE	Heat shock cognate 71 kDa protein	Hspa8	7.174	144.411	0.327	0.000
2	Q64332	SYN2_MOUSE	Synapsin-2	Syn2	5.058	33.318	0.178	0.000
3	P97429	ANXA4_MOUSE	Annexin A4	Anxa4	2.738	6.670	0.220	0.000
4	Q9JIS5	SV2A_MOUSE	Synaptic vesicle glycoprotein 2A	Sv2a	2.552	5.866	0.448	0.000
5	P08551	NFL_MOUSE	Neurofilament light polypeptide	Nefl	2.419	5.350	0.421	0.000
6	Q99104	MYO5A_MOUSE	Unconventional myosin-Va	Myo5a	2.221	4.661	0.248	0.000
7	O08532	CA2D 1_MOUSE	Voltage-dependent calcium channel subunit alpha-	Cacna2d1	1.902	3.737	0.451	0.000
8	P11835	ITB2_MOUSE	Integrin beta-2	Itgb2	1.873	3.663	0.170	0.000
9	Q62261	SPTB2_MOUSE	Spectrin beta chain, non-erythrocytic 1	Sptbn1	1.829	3.554	0.240	0.000
10	P20060	HEXB_MOUSE	Beta-hexosaminidase subunit beta	Hexb	1.544	2.915	0.018	0.000
11	P62631	EF1A2_MOUSE	Elongation factor 1-alpha 2	Eef1a2	1.438	2.710	0.108	0.000
12	P39053	DYN1_MOUSE	Dynamin-1	Dnm1	1.325	2.505	0.533	0.024
13	P47740	AL3 A2_MOUSE	Fatty aldehyde dehydrogenase	Aldh3a2	1.268	2.408	0.065	0.000
14	P09055	ITB1_MOUSE	Integrin beta-1	Itgb1	1.128	2.185	0.131	0.000
15	P55088	AQP4_MOUSE	Aquaporin-4	Aqp4	1.092	2.132	0.079	0.000
16	P48036	ANXA5_MOUSE	Annexin A5	Anxa5	1.049	2.070	0.165	0.000
56	O55125	NIPS1_MOUSE	Protein NipSnap homolog 1	Nipsnap1	-1.838	-3.575	0.425	0.000
57	Q8BYI9	TENR_MOUSE	Tenascin-R	Tnr	-1.857	-3.622	0.243	0.000
58	P50396	GDIA_MOUSE	Rab GDP dissociation inhibitor alpha	Gdi1	-1.974	-3.929	0.186	0.000
59	Q8BG39	SV2 B_MOUSE	Synaptic vesicle glycoprotein 2B	Sv2b	-1.980	-3.945	0.584	0.007
60	Q8VDQ8	SIR2_MOUSE	NAD-dependent protein deacetylase sirtuin-2	Sirt2	-1.980	-3.945	0.402	0.000
61	Q9D051	ODPB_MOUSE	Pyruvate dehydrogenase E1 component subunit be	Pdhb	-2.282	-4.864	0.228	0.000
62	Q9CPU4	MGST3_MOUSE	Microsomal glutathione S-transferase 3	Mgst3	-2.323	-5.004	0.305	0.000
63	Q9D2G2	ODO2_MOUSE	Dihydrolipoyllysine-residue succinyltransferase co	Dlst	-2.355	-5.116	0.144	0.000
64	P08113	ENPL_MOUSE	Endoplasmin	Hsp90b1	-2.376	-5.190	0.434	0.000
65	Q9CQC7	NDUB4_MOUSE	NADH dehydrogenase [ubiquinone] 1 beta subcom	Ndufb4	-2.559	-5.893	0.166	0.000
66	P34884	MIF_MOUSE	Macrophage migration inhibitory factor	Mif	-2.623	-6.162	0.060	0.000
67	Q9DB20	ATPO_MOUSE	AT P synthase subunit O, mitochondrial	Atp5o	-2.681	-6.411	0.558	0.000
68	P12787	COX5 A_MOUSE	Cytochrome c oxidase subunit 5A, mitochondrial	Cox5a	-2.741	-6.684	0.305	0.000
69	O55143	AT2 A2_MOUSE	Sarcoplasmic/endoplasmic reticulum calcium AT P	Atp2a2	-2.821	-7.066	0.240	0.000
70	P70704	AT8A 1_MOUSE	Phospholipid-transporting ATPase IA	Atp8a1	-3.291	-9.790	0.296	0.000
71	Q9CQQ7	AT5F1_MOUSE	AT P synthase F(0) complex subunit B1, mitochon	Atp5f1	-3.578	-11.942	0.232	0.000
72	Q8K2B3	SDH A_MOUSE	Succinate dehydrogenase [ubiquinone] flavoprotei	Sdha	-4.627	-24.706	0.252	0.000
73	P40124	CAP1_MOUSE	Adenylyl cyclase-associated protein 1	Cap1	-4.813	-28.115	0.356	0.000
74	Q99N28	CAD M3_MOUSE	Cell adhesion molecule 3	Cadm3	-5.037	-32.842	0.502	0.000