Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1985 Dec;40(12):925–930. doi: 10.1136/thx.40.12.925

Indium 111 autologous leucocyte scanning in lobar pneumonia and lung abscesses.

S H Saverymuttu, G Phillips, A M Peters, J P Lavender
PMCID: PMC460228  PMID: 4095674

Abstract

Indium 111 leucocyte scanning was used to examine the kinetics of granulocyte localisation in five patients with lobar pneumonia and four patients with lung abscess. Lung abscesses showed dense accumulation of labelled granulocytes within four hours of injection. In contrast, in all cases of lobar pneumonia granulocytes failed to accumulate over a period of up to 24 hours despite evidence of adequate perfusion and of uptake in inflammation elsewhere. These results suggest that the recruitment of granulocytes to lobar pneumonia may be terminated early in its clinical course.

Full text

PDF
925

Images in this article

926Image
on p.926
927Image
on p.927
927Image
on p.927
927Image
on p.927
928Image
on p.928

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. R., Spence R. A., Laird J. D., Ferguson W. R., Kennedy T. L. Initial experience with indium-111 autologous leucocyte imaging in patients with acute pancreatitis. Br Med J (Clin Res Ed) 1983 Sep 3;287(6393):637–638. doi: 10.1136/bmj.287.6393.637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Buescher E. S., Gallin J. I. Leukocyte transfusions in chronic granulomatous disease: persistence of transfused leukocytes in sputum. N Engl J Med. 1982 Sep 23;307(13):800–803. doi: 10.1056/NEJM198209233071306. [DOI] [PubMed] [Google Scholar]
  3. Coleman R. E., Black R. E., Welch D. M., Maxwell J. G. Indium-111 labeled leukocytes in the evaluation of suspected abdominal abscesses. Am J Surg. 1980 Jan;139(1):99–104. doi: 10.1016/0002-9610(80)90237-8. [DOI] [PubMed] [Google Scholar]
  4. Forstrom L. A., Loken M. K., Cook A., Chandler R., McCullough J. In-111-labeled leukocytes in the diagnosis of rejection and cytomegalovirus infection in renal transplant patients. Clin Nucl Med. 1981 Apr;6(4):146–148. doi: 10.1097/00003072-198104000-00002. [DOI] [PubMed] [Google Scholar]
  5. Gray H. W., Cuthbert I., Richards J. R. Clinical imaging with indium-111 leukocytes: uptake in bowel infarction. J Nucl Med. 1981 Aug;22(8):701–702. [PubMed] [Google Scholar]
  6. Lavender J. P., Irving H., Armstrong J. D., 2nd Krypton-81m ventilation scanning: acute respiratory disease. AJR Am J Roentgenol. 1981 Feb;136(2):309–316. doi: 10.2214/ajr.136.2.309. [DOI] [PubMed] [Google Scholar]
  7. Lichter J. P., Konopka R. G., Hartman M. T., Moser K. M., Spragg R. G. The in vivo behavior of granulocytes labeled with indium-111 in a canine model of pneumococcal pneumonia. Am Rev Respir Dis. 1984 Apr;129(4):602–606. [PubMed] [Google Scholar]
  8. McDougall I. R., Baumert J. E., Lantieri R. L. Evaluation of 111In leukocyte whole body scanning. AJR Am J Roentgenol. 1979 Nov;133(5):849–854. doi: 10.2214/ajr.133.5.849. [DOI] [PubMed] [Google Scholar]
  9. Peters A. M., Saverymuttu S. H., Reavy H. J., Danpure H. J., Osman S., Lavender J. P. Imaging of inflammation with indium-111 tropolonate labeled leukocytes. J Nucl Med. 1983 Jan;24(1):39–44. [PubMed] [Google Scholar]
  10. Raptopoulos V., Doherty P. W., Goss T. P., King M. A., Johnson K., Gantz N. M. Acute osteomyelitis: advantage of white cell scans in early detection. AJR Am J Roentgenol. 1982 Dec;139(6):1077–1082. doi: 10.2214/ajr.139.6.1077. [DOI] [PubMed] [Google Scholar]
  11. Saverymuttu S. H., Peters A. M., Danpure H. J., Reavy H. J., Osman S., Lavender J. P. Lung transit of 111Indium-labelled granulocytes. Relationship to labelling techniques. Scand J Haematol. 1983 Feb;30(2):151–160. doi: 10.1111/j.1600-0609.1983.tb01463.x. [DOI] [PubMed] [Google Scholar]
  12. Saverymuttu S. H., Peters A. M., Lavender J. P., Hodgson H. J., Chadwick V. S. 111Indium autologous leucocytes in inflammatory bowel disease. Gut. 1983 Apr;24(4):293–299. doi: 10.1136/gut.24.4.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Saverymuttu S. H., Peters A. M., Lavender J. P., Pepys M. B., Hodgson H. J., Chadwick V. S. Quantitative fecal indium 111-labeled leukocyte excretion in the assessment of disease in Crohn's disease. Gastroenterology. 1983 Dec;85(6):1333–1339. [PubMed] [Google Scholar]
  14. Saverymuttu S. H., Peters A. M., Reavy H. J., Lavender J. P. Measurement of granulocyte migration and accumulation in inflammation in man. Clin Exp Immunol. 1983 Jun;52(3):607–612. [PMC free article] [PubMed] [Google Scholar]
  15. Segal A. W., Ensell J., Munro J. M., Sarner M. Indium-111 tagged leucocytes in the diagnosis of inflammatory bowel disease. Lancet. 1981 Aug 1;2(8240):230–232. doi: 10.1016/s0140-6736(81)90477-3. [DOI] [PubMed] [Google Scholar]
  16. Wilson D. G., Seabold J. E., Lieberman L. M. Detection of aortoarterial graft infections by leukocyte scintigraphy. Clin Nucl Med. 1983 Sep;8(9):421–423. doi: 10.1097/00003072-198309000-00009. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES