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. 1986 Jan;41(1):6–11. doi: 10.1136/thx.41.1.6

Physiological evidence that emphysema is not a feature of byssinosis.

D Honeybourne, C A Pickering
PMCID: PMC460244  PMID: 3704968

Abstract

A group of women with byssinosis of grades 2 and 3 were seen consecutively over three years in an occupational outpatient clinic. Detailed lung function tests were performed and the results for smokers and non-smokers compared. One hundred and fifty three patients were seen and 50 of these were life time non-smokers, 35 smoked one to nine cigarettes a day, and 68 smoked 10 or more cigarettes a day. After correction for age the mean FEV1 was found to be significantly lower (p less than 0.01) in heavy smokers than in non-smokers. In a subgroup of 89 subjects who were able to perform the carbon monoxide gas transfer test significantly lower values were obtained for the carbon monoxide transfer factor (TLCO), (p less than 0.001), TLCO % predicted (p less than 0.001), and the transfer coefficient (KCO) (p less than 0.001) in the heavy smokers than in the non-smokers, despite the fact that the non-smokers had worked longer in the cotton mills (p less than 0.02). The mean TLCO was significantly lower than predicted in the heavy smokers (p less than 0.001) but not in the non-smokers. A significant negative correlation was found between the number of cigarettes smoked per day and the TLCO (p less than 0.01), TLCO % predicted (p less than 0.001), and KCO (p = 0.005), but not with the number of years spent in the carding area. These results provide evidence supporting recent pathological observations that emphysema is probably due to concomitant cigarette smoking and is not itself a feature of byssinosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Edwards C., Macartney J., Rooke G., Ward F. The pathology of the lung in byssinotics. Thorax. 1975 Dec;30(6):612–623. doi: 10.1136/thx.30.6.612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. FLETCHER C. M., HUGH-JONES P., McNICOL M. W., PRIDE N. B. The diagnosis of pulmonary emphysema in the presence of chronic bronchitis. Q J Med. 1963 Jan;32:33–49. [PubMed] [Google Scholar]
  3. Gandevia B., Milne J. Ventilatory capacity changes on exposure to cotton dust and their relevance to byssinosis in Australia. Br J Ind Med. 1965 Oct;22(4):295–304. doi: 10.1136/oem.22.4.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. González E., Weill H., Ziskind M. M., George R. B. The value of the single breath diffusing capacity in separating chronic bronchitis from pulmonary emphysema. Dis Chest. 1968 Mar;53(3):229–236. doi: 10.1378/chest.53.3.229. [DOI] [PubMed] [Google Scholar]
  5. Guyatt A. R., Douglas J. S., Zuskin E., Bouhuys A. Lung static recoil and airway obstruction in hemp workers with byssinosis. Am Rev Respir Dis. 1973 Nov;108(5):1111–1115. doi: 10.1164/arrd.1973.108.5.1111. [DOI] [PubMed] [Google Scholar]
  6. Merchant J. A., Halprin G. M., Hudson A. R., Kilburn K. H., McKenzie W. M., Jr, Bermanzohn P., Hurst D. J., Hamilton J. D., Germino V. H., Jr Evaluation before and after exposure--the pattern of physiological response to cotton dust. Ann N Y Acad Sci. 1974;221:38–43. doi: 10.1111/j.1749-6632.1974.tb28196.x. [DOI] [PubMed] [Google Scholar]
  7. Morgan W. K., Vesterlund J., Burrell R., Gee J. B., Willoughby W. F. Byssinosis: some unanswered questions. Am Rev Respir Dis. 1982 Aug;126(2):354–357. doi: 10.1164/arrd.1982.126.2.354. [DOI] [PubMed] [Google Scholar]
  8. Pratt P. C., Vollmer R. T., Miller J. A. Epidemiology of pulmonary lesions in nontextile and cotton textile workers: a retrospective autopsy analysis. Arch Environ Health. 1980 May-Jun;35(3):133–138. doi: 10.1080/00039896.1980.10667480. [DOI] [PubMed] [Google Scholar]
  9. Pratt P. C., Vollmer R. T., Miller J. A. Prevalence and severity of morphologic emphysema and bronchitis in non-textile and cotton-textile workers. Chest. 1980 Feb;77(2 Suppl):323–325. doi: 10.1378/chest.77.2.323. [DOI] [PubMed] [Google Scholar]
  10. ROACH S. A., SCHILLING R. S. A clinical and environmental study of byssinosis in the Lancashire cotton industry. Br J Ind Med. 1960 Jan;17:1–9. doi: 10.1136/oem.17.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rees P. J., Chilvers C., Clark T. J. Evaluation of methods used to estimate inhaled dose of carbon monoxide. Thorax. 1980 Jan;35(1):47–51. doi: 10.1136/thx.35.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schachter E. N., Maunder L. R., Beck G. J. The pattern of lung function abnormalities in cotton textile workers. Am Rev Respir Dis. 1984 Apr;129(4):523–527. [PubMed] [Google Scholar]
  13. Van Ganse W. F., Ferris B. G., Jr, Cotes J. E. Cigarette smoking and pulmonary diffusing capacity. (Transfer factor). Am Rev Respir Dis. 1972 Jan;105(1):30–41. doi: 10.1164/arrd.1972.105.1.30. [DOI] [PubMed] [Google Scholar]
  14. Zuskin E., Valić F. Respiratory symptoms and ventilatory function changes in relation to length of exposure to cotton dust. Thorax. 1972 Jul;27(4):454–458. doi: 10.1136/thx.27.4.454. [DOI] [PMC free article] [PubMed] [Google Scholar]

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