Abstract
In a large scale clinical survey of Scottish pigeon fanciers, 277 people completed a detailed questionnaire and provided a venous blood sample. There were 29 (10.4%) who fulfilled the clinical criteria for pigeon breeders' disease used in the study and 84 (30.3%) who showed a significant serum IgG antibody response to pigeon gammaglobulin (4 micrograms/ml) and were considered to have been sensitised. Increasing exposure was associated with a progressive tendency towards sensitisation, but the intensity of the antibody response was related to the presence of symptoms and not the degree of exposure. Thirteen out of 15 subjects in the survey with a serum concentration of antipigeon IgG greater than 60 micrograms/ml fulfilled the clinical criteria for pigeon breeders' disease, and those affected within 10 years of starting the hobby had the highest mean antibody response. Accurate quantitation of antibody response is therefore helpful in the investigation of pigeon breeders' disease. The radioimmunoassay provides a quantitative method for determining antibody response that can be used in the routine screening of pigeon fanciers and in serial monitoring of their response.
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Selected References
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- Christensen L. T., Schmidt C. D., Robbins L. Pigeon breeders' disease--a prevalence study and review. Clin Allergy. 1975 Dec;5(4):417–430. doi: 10.1111/j.1365-2222.1975.tb01881.x. [DOI] [PubMed] [Google Scholar]
- Elgerfors B., Belin L., Hanson L. A. Pigeon breeder's lung. Clinical and immunological observations. Scand J Respir Dis. 1971;52(3):167–176. [PubMed] [Google Scholar]
- Fink J. N., Barboriak J. J., Sosman A. J., Bukosky R. J., Arkins J. A. Antibodies against pigeon serum proteins in pigeon breeders. J Lab Clin Med. 1968 Jan;71(1):20–24. [PubMed] [Google Scholar]
- Fink J. N., Schlueter D. P., Sosman A. J., Unger G. F., Barboriak J. J., Rimm A. A., Arkins J. A., Dhaliwal K. S. Clinical survey of pigeon breeders. Chest. 1972 Sep;62(3):277–281. doi: 10.1378/chest.62.3.277. [DOI] [PubMed] [Google Scholar]
- McConahey P. J., Dixon F. J. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol. 1966;29(2):185–189. doi: 10.1159/000229699. [DOI] [PubMed] [Google Scholar]
- Moore V. L., Fink J. N. Immunologic studies in hypersensitivity pneumonitis--quantitative precipitins and complement-fixing antibodies in symptomatic and asymptomatic pigeon breeders. J Lab Clin Med. 1975 Apr;85(4):540–545. [PubMed] [Google Scholar]
- REED C. E., BARBEE R. A. PIGEON-BREEDERS' LUNG: A NEWLY OBSERVED INTERSTITIAL PULMONARY DISEASE. JAMA. 1965 Jul 26;193:261–265. doi: 10.1001/jama.1965.03090040005001. [DOI] [PubMed] [Google Scholar]
- Schuyler M. R., Kleinerman J., Pensky J. R., Brandt C., Schmitt D. Pulmonary response to repeated exposure to Micropolyspora faeni. Am Rev Respir Dis. 1983 Dec;128(6):1071–1076. doi: 10.1164/arrd.1983.128.6.1071. [DOI] [PubMed] [Google Scholar]
- Sennekamp J., Niese D., Stroehmann I., Rittner C. Pigeon breeders' lung lacking detectable antibodies. Clin Allergy. 1978 May;8(3):305–310. doi: 10.1111/j.1365-2222.1978.tb03228.x. [DOI] [PubMed] [Google Scholar]