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. 1986 Apr;41(4):301–305. doi: 10.1136/thx.41.4.301

Effect of selective and non-selective beta blockade on pulmonary function and tracheobronchial mucociliary clearance in healthy subjects.

D Pavia, J R Bateman, A M Lennard-Jones, J E Agnew, S W Clarke
PMCID: PMC460314  PMID: 3526627

Abstract

A controlled, double blind, crossover study was carried out to ascertain the effect of single doses of selective (100 mg atenolol) and non-selective (160 mg propranolol) beta blocker on pulmonary function and tracheobronchial mucociliary clearance. The study group comprised 12 healthy, young subjects. Adequate and comparable blockade was achieved with both drugs, the administration of which resulted in significantly lower pulse rates (at least up to eight hours after administration of the drug) and systolic blood pressures (three hours after drug administration) than were found with placebo. Small (of the order of 5%) but nevertheless statistically significant falls in FEV1 and forced vital capacity accompanied the administration of both beta blockers (but not the placebo) and were measurable up to eight hours after administration of the drug. Indices of pulmonary function had returned to normal by the next day. Peak expiratory flow and indices of small airways function remained unaltered after beta blockade. Mean tracheobronchial mucociliary clearance was depressed after administration of both beta blocking drugs, although the reduction was significant (p less than 0.05) only when propranolol was compared with placebo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Camner P., Philipson K. Human alveolar deposition of 4 micron teflon particles. Arch Environ Health. 1978 Jul-Aug;33(4):181–185. doi: 10.1080/00039896.1978.10667331. [DOI] [PubMed] [Google Scholar]
  2. Camner P., Strandberg K., Philipson K. Increased mucociliary transport by adrenergic stimulation. Arch Environ Health. 1976 Mar-Apr;31(2):79–82. doi: 10.1080/00039896.1976.10667194. [DOI] [PubMed] [Google Scholar]
  3. Dorow P., Weiss T., Felix R., Schmutzler H., Schiess W. Influence of propranolol, metoprolol, and pindolol on mucociliary clearance in patients with coronary heart disease. Respiration. 1984;45(3):286–290. doi: 10.1159/000194632. [DOI] [PubMed] [Google Scholar]
  4. Fazio F., Lafortuna C. Effect of inhaled salbutamol on mucociliary clearance in patients with chronic bronchitis. Chest. 1981 Dec;80(6 Suppl):827–830. doi: 10.1378/chest.80.6.827. [DOI] [PubMed] [Google Scholar]
  5. Foster W. M., Bergofsky E. H., Bohning D. E., Lippmann M., Albert R. E. Effect of adrenergic agents and their mode of action on mucociliary clearance in man. J Appl Physiol. 1976 Aug;41(2):146–152. doi: 10.1152/jappl.1976.41.2.146. [DOI] [PubMed] [Google Scholar]
  6. Gamsu G., Singer M. M., Vincent H. H., Berry S., Nadel J. A. Postoperative impairment of mucous transport in the lung. Am Rev Respir Dis. 1976 Oct;114(4):673–679. doi: 10.1164/arrd.1976.114.4.673. [DOI] [PubMed] [Google Scholar]
  7. Knudson R. J., Lebowitz M. D., Holberg C. J., Burrows B. Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis. 1983 Jun;127(6):725–734. doi: 10.1164/arrd.1983.127.6.725. [DOI] [PubMed] [Google Scholar]
  8. Konietzko N., Klopfer M., Adam W. E., Matthys H. Die mukociliare Klärfunktion der Lunge unter beta-adrenerger Stimulation. Pneumonologie. 1975 Sep 26;152(1-3):203–208. doi: 10.1007/BF02101588. [DOI] [PubMed] [Google Scholar]
  9. Lopez-Vidriero M. T. Airway mucus; production and composition. Chest. 1981 Dec;80(6 Suppl):799–804. [PubMed] [Google Scholar]
  10. Mossberg B., Afzelius B. A., Eliasson R., Camner P. On the pathogenesis of obstructive lung disease. A study on the immotile-cilia syndrome. Scand J Respir Dis. 1978 Apr;59(2):55–65. [PubMed] [Google Scholar]
  11. Pavia D., Bateman J. R., Clarke S. W. Deposition and clearance of inhaled particles. Bull Eur Physiopathol Respir. 1980 May-Jun;16(3):335–366. [PubMed] [Google Scholar]
  12. Pavia D., Sutton P. P., Agnew J. E., Lopez-Vidriero M. T., Newman S. P., Clarke S. W. Measurement of bronchial mucociliary clearance. Eur J Respir Dis Suppl. 1983;127:41–56. [PubMed] [Google Scholar]
  13. Pavia D., Thomson M. L., Clarke S. W., Shannon H. S. Effect of lung function and mode of inhalation on penetration of aerosol into the human lung. Thorax. 1977 Apr;32(2):194–197. doi: 10.1136/thx.32.2.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Santa Cruz R., Landa J., Hirsch J., Sackner M. A. Tracheal mucous velocity in normal man and patients with obstructive lung disease: effects of terbutaline. Am Rev Respir Dis. 1974 Apr;109(4):458–463. doi: 10.1164/arrd.1974.109.4.458. [DOI] [PubMed] [Google Scholar]
  15. Sill V., Novak D., Kaukel E., Lanser K. Schätzung der mukoziliaren Clearance mittels Pharmako-Bronchographie. Prax Pneumol. 1976 Jun;30(6):339–343. [PubMed] [Google Scholar]
  16. Sturgess J., Reid L. An organ culture study of the effect of drugs on the secretory activity of the human bronchial submucosal gland. Clin Sci. 1972 Oct;43(4):533–543. doi: 10.1042/cs0430533. [DOI] [PubMed] [Google Scholar]
  17. Sutton P. P., Pavia D., Bateman J. R., Clarke S. W. The effect of oral aminophylline on lung mucociliary clearance in man. Chest. 1981 Dec;80(6 Suppl):889–892. [PubMed] [Google Scholar]
  18. Thomson M. L., Pavia D. Long-term tobacco smoking and mucociliary clearance from the human lung in health and respiratory impairment. Arch Environ Health. 1973 Feb;26(2):86–89. doi: 10.1080/00039896.1973.10666230. [DOI] [PubMed] [Google Scholar]
  19. Thomson M. L., Short M. D. Mucociliary function in health, chronic obstructive airway disease, and asbestosis. J Appl Physiol. 1969 May;26(5):535–539. doi: 10.1152/jappl.1969.26.5.535. [DOI] [PubMed] [Google Scholar]
  20. Verdugo P., Johnson N. T., Tam P. Y. beta-Adrenergic stimulation of respiratory ciliary activity. J Appl Physiol Respir Environ Exerc Physiol. 1980 May;48(5):868–871. doi: 10.1152/jappl.1980.48.5.868. [DOI] [PubMed] [Google Scholar]
  21. Yeates D. B., Aspin N., Levison H., Jones M. T., Bryan A. C. Mucociliary tracheal transport rates in man. J Appl Physiol. 1975 Sep;39(3):487–495. doi: 10.1152/jappl.1975.39.3.487. [DOI] [PubMed] [Google Scholar]

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