Fig. 7.
Neuroprotection against cell death is limited to an early segment of the whole erythropoietin (EPO) molecule. PC12 cells were exposed in vitro to toxic Aβ25–35 peptide to induce cell death. The apoptotic cell fraction from fluorescence-activated cell sorting analysis was calculated to quantify the proportion of dead and dying cells. Toxic exposure to Aβ peptide induced large levels of cellular apoptosis that was dramatically reduced by pretreatment with whole EPO, JM-4 peptide, or the second segment of EPO (EP-P#2) **p < 0.01, ***p < 0.001