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. 1986 Nov;41(11):875–879. doi: 10.1136/thx.41.11.875

Interpretation of negative results in fine needle aspiration of discrete pulmonary lesions.

A J Winning, J McIvor, W A Seed, O A Husain, N Metaxas
PMCID: PMC460513  PMID: 3824273

Abstract

A retrospective analysis was carried out on a consecutive series of 181 percutaneous fine needle aspiration biopsies of discrete pulmonary lesions, in which the outcome was established in 95%. In primary bronchial carcinoma the technique had a sensitivity of 86%. There was no relationship between the size, location, or radiological appearance of the lesion and the incidence of false negative results. The principal reason for failure to diagnose malignancy was inadequacy of the material provided for cytological examination. For metastatic neoplasms of non-bronchial origin the procedure had a sensitivity of 42% and a significantly greater false negative rate than for primary bronchial malignancy. For the entire series 72 (40%) of the procedures failed to produce a definite diagnosis, 29 (40%) of these cases subsequently proving to be malignant. A positive diagnosis was established in only 16% of patients with benign conditions. Review of published reports and consideration of the role of this and other biopsy techniques in the investigation of discrete pulmonary lesions lead to the conclusion that needle aspiration biopsy seems particularly appropriate in the investigation of inoperable patients with probable bronchial carcinoma in whom sputum cytology and bronchoscopy do not yield a diagnosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adamson J. S., Jr, Bates J. H. Percutaneous needle biopsy of the lung. Arch Intern Med. 1967 Feb;119(2):164–169. [PubMed] [Google Scholar]
  2. Allison D. J., Hemingway A. P. Percutaneous needle biopsy of the lung. Br Med J (Clin Res Ed) 1981 Mar 14;282(6267):875–878. doi: 10.1136/bmj.282.6267.875. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Aronovitch M., Chartier J., Kahana L. M., Meakins J. F., Groszman M. Needle Biopsy as an Aid to the Precise Diagnosis of Intrathoracic Disease. Can Med Assoc J. 1963 Jan 19;88(3):120–127. [PMC free article] [PubMed] [Google Scholar]
  4. Berquist T. H., Bailey P. B., Cortese D. A., Miller W. E. Transthoracic needle biopsy: accuracy and complications in relation to location and type of lesion. Mayo Clin Proc. 1980 Aug;55(8):475–481. [PubMed] [Google Scholar]
  5. Gibney R. T., Man G. C., King E. G., leRiche J. Aspiration biopsy in the diagnosis of pulmonary disease. Chest. 1981 Sep;80(3):300–303. doi: 10.1378/chest.80.3.300. [DOI] [PubMed] [Google Scholar]
  6. Harrison B. D., Thorpe R. S., Kitchener P. G., McCann B. G., Pilling J. R. Percutaneous Trucut lung biopsy in the diagnosis of localised pulmonary lesions. Thorax. 1984 Jul;39(7):493–499. doi: 10.1136/thx.39.7.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Janower M. L., Land R. E. Lung biopsy. Bronchial brushing and percutaneous puncture. Radiol Clin North Am. 1971 Apr;9(1):73–83. [PubMed] [Google Scholar]
  8. Lalli A. F., McCormack L. J., Zelch M., Reich N. E., Belovich D. Aspiration biopsies of chest lesions. Radiology. 1978 Apr;127(1):35–40. doi: 10.1148/127.1.35. [DOI] [PubMed] [Google Scholar]
  9. Lees W. R., Hall-Craggs M. A., Manhire A. Five years' experience of fine-needle aspiration biopsy: 454 consecutive cases. Clin Radiol. 1985 Sep;36(5):517–520. doi: 10.1016/s0009-9260(85)80204-x. [DOI] [PubMed] [Google Scholar]
  10. Mitchell D. M., Emerson C. J., Collins J. V., Stableforth D. E. Transbronchial lung biopsy with the fibreoptic bronchoscope: analysis of results in 433 patients. Br J Dis Chest. 1981 Jul;75(3):258–262. doi: 10.1016/0007-0971(81)90003-6. [DOI] [PubMed] [Google Scholar]
  11. Poe R. H., Tobin R. E. Sensitivity and specificity of needle biopsy in lung malignancy. Am Rev Respir Dis. 1980 Nov;122(5):725–729. doi: 10.1164/arrd.1980.122.5.725. [DOI] [PubMed] [Google Scholar]
  12. Sargent E. N., Turner A. F., Gordonson J., Schwinn C. P., Pashky O. Percutaneous pulmonary needle biopsy. Report of 350 patients. Am J Roentgenol Radium Ther Nucl Med. 1974 Dec;122(4):758–768. doi: 10.2214/ajr.122.4.758. [DOI] [PubMed] [Google Scholar]
  13. Sinner W. N. Complications of percutaneous transthoracic needle aspiration biopsy. Acta Radiol Diagn (Stockh) 1976 Nov;17(6):813–828. doi: 10.1177/028418517601700609. [DOI] [PubMed] [Google Scholar]
  14. Sinner W. N. Pulmonary neoplasms diagnosed with transthoracic needle biopsy. Cancer. 1979 Apr;43(4):1533–1540. doi: 10.1002/1097-0142(197904)43:4<1533::aid-cncr2820430447>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  15. Stableforth D. E., Knight R. K., Collins J. V., Heard B. E., Clarke S. W. Transbronchial lung biopsy through the fibreoptic bronchoscope. Br J Dis Chest. 1978 Apr;72(2):108–114. doi: 10.1016/0007-0971(78)90019-0. [DOI] [PubMed] [Google Scholar]
  16. Stevens G. M., Weigen J. F., Lillington G. A. Needle aspiration biopsy of localized pulmonary lesions with amplified fluoroscopic guidance. Am J Roentgenol Radium Ther Nucl Med. 1968 Jul;103(3):561–571. doi: 10.2214/ajr.103.3.561. [DOI] [PubMed] [Google Scholar]
  17. Thornbury J. R., Burke D. P., Naylor B. Transthoracic needle aspiration biopsy: accuracy of cytologic typing of malignant neoplasms. AJR Am J Roentgenol. 1981 Apr;136(4):719–724. doi: 10.2214/ajr.136.4.719. [DOI] [PubMed] [Google Scholar]
  18. Zavala D. C., Bedell G. N. Percutaneous lung biopsy with a cutting needle. An analysis of 40 cases and comparison with other biopsy techniques. Am Rev Respir Dis. 1972 Aug;106(2):186–193. doi: 10.1164/arrd.1972.106.2.186. [DOI] [PubMed] [Google Scholar]

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