Abstract
Over the past 25 years the incidence of tuberculosis in Blackburn has changed from one that was below the national average to one which is consistently in the 10 highest local authority areas in England and Wales. A survey of primary and acquired drug resistance over the same period included 974 ethnic white patients and 538 of Indian subcontinent ethnic origin. Primary drug resistance in the white population has fallen consistently from 1965 onwards and is now zero. Only one case of acquired resistance has occurred in the last five years. Primary resistance in the immigrant community has been 11-15% from 1965 onwards, and five cases of acquired resistance have occurred since 1970. The pattern of drug resistance over this period supports the view that there is no evidence of cross infection between the native white and immigrant ethnic groups.
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Selected References
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- Bates J. H., Mitchison D. A. Geographic distribution of bacteriophage types of Mycobacterium tuberculosis. Am Rev Respir Dis. 1969 Aug;100(2):189–193. doi: 10.1164/arrd.1969.100.2.189. [DOI] [PubMed] [Google Scholar]
- FOX W., WIENER A., MITCHISON D. A., SELKON J. B., SUTHERLAND I. The prevalence of drug-resistant tubercle bacilli in untreated patients with pulmonary tuberculosis; a national survey, 1955-56. Tubercle. 1957 Apr;38(2):71–84. doi: 10.1016/s0041-3879(57)80001-4. [DOI] [PubMed] [Google Scholar]
- Gardner P. A., Moss P. D., Stalker R. Tuberculosis and the immigrant in Blackburn. Public Health. 1972 May;86(4):189–197. doi: 10.1016/s0033-3506(72)80017-9. [DOI] [PubMed] [Google Scholar]
- Grange J. M., Aber V. R., Allen B. W., Mitchison D. A., Mikhail J. R., McSwiggan D. A., Collins C. H. Comparison of strains of Mycobacterium tuberculosis from British, Ugandan and Asian immigrant patients: a study in bacteriophage typing, susceptibility to hydrogen peroxide and sensitivity to thiophen-2-carbonic acid hydrazide. Tubercle. 1977 Dec;58(4):207–215. doi: 10.1016/0041-3879(77)90045-9. [DOI] [PubMed] [Google Scholar]
- Grange J. M., Collins C. H., McSwiggan D. Bacteriophage typing of Mycobacterium tuberculosis strains isolated in South East England. Tubercle. 1976 Mar;57(1):59–66. doi: 10.1016/0041-3879(76)90018-0. [DOI] [PubMed] [Google Scholar]
- Miller A. B., Tall R., Fox W., Lefford M. J., Mitchison D. A. Primary drug resistance in pulmonary tuberculosis in Great Britain: second national survey, 1963. Tubercle. 1966 Mar;47(1):92–108. doi: 10.1016/s0041-3879(66)80053-3. [DOI] [PubMed] [Google Scholar]