Abstract
Ten symptomless smokers were switched from their usual cigarette to a low tar, low nicotine test cigarette for two weeks to investigate their immediate response and subsequent acclimatisation to the test cigarette. The tar (T) and nicotine (N) yields of the test cigarettes were T = 3.8 mg, N = 0.6 mg; the median yields of the usual cigarettes were T = 16.4 mg, N = 1.4 mg. The subjects were monitored over a six week period comprising a control period (usual cigarette), a test period (test cigarette), and a return period (usual cigarette), each lasting two weeks. The inhaled smoke volume (smoke from the burning tip of the cigarette which is subsequently inhaled) was measured with a non-invasive radiotracer technique. Puffing indices were recorded using an electronic smoking analyser and flowhead cigarette holder. Measurements were made at the beginning of the control period, at the beginning and end of the test period, and at the end of the return period. Subjects kept records of their cigarette consumption during each of the three periods. Apart from a small change in puff duration, cigarettes were smoked in the same way during the control and return periods. Mean and total puff volumes increased with the low tar, low nicotine cigarette but did not change from the beginning to the end of the test period. There was no significant change between the control, test, and return periods for mean inhaled smoke volume, total inhaled smoke volume, or cigarette consumption. It is concluded that when smokers are switched to a low tar, low nicotine cigarette the puff volume increases but there is no change in the inhaled smoke volume or daily consumption.
Full text
PDF





Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adams L., Lee C., Rawbone R., Guz A. Patterns of smoking: measurement and variability in asymptomatic smokers. Clin Sci (Lond) 1983 Oct;65(4):383–392. doi: 10.1042/cs0650383. [DOI] [PubMed] [Google Scholar]
- Altman D. G., Gore S. M., Gardner M. J., Pocock S. J. Statistical guidelines for contributors to medical journals. Br Med J (Clin Res Ed) 1983 May 7;286(6376):1489–1493. doi: 10.1136/bmj.286.6376.1489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ashton H., Stepney R., Thompson J. W. Self-titration by cigarette smokers. Br Med J. 1979 Aug 11;2(6186):357–360. doi: 10.1136/bmj.2.6186.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ashton H., Watson D. W. Puffing frequency and nicotine intake in cigarette smokers. Br Med J. 1970 Sep 19;3(5724):679–681. doi: 10.1136/bmj.3.5724.679. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Benowitz N. L., Jacob P., 3rd Daily intake of nicotine during cigarette smoking. Clin Pharmacol Ther. 1984 Apr;35(4):499–504. doi: 10.1038/clpt.1984.67. [DOI] [PubMed] [Google Scholar]
- Ebert R. V., McNabb M. E., McCusker K. T., Snow S. L. Amount of nicotine and carbon monoxide inhaled by smokers of low-tar, low-nicotine cigarettes. JAMA. 1983 Nov 25;250(20):2840–2842. [PubMed] [Google Scholar]
- Grant S. G., Woodman G., Newman S. P., Pavia D., Clarke S. W. Sensory mechanisms in the upper respiratory tract affect the inhalation of cigarette smoke in man. Clin Sci (Lond) 1986 Jul;71(1):117–119. doi: 10.1042/cs0710117. [DOI] [PubMed] [Google Scholar]
- Herning R. I., Jones R. T., Bachman J., Mines A. H. Puff volume increases when low-nicotine cigarettes are smoked. Br Med J (Clin Res Ed) 1981 Jul 18;283(6285):187–189. doi: 10.1136/bmj.283.6285.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Knudson R. J., Lebowitz M. D., Holberg C. J., Burrows B. Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis. 1983 Jun;127(6):725–734. doi: 10.1164/arrd.1983.127.6.725. [DOI] [PubMed] [Google Scholar]
- McBride M. J., Guyatt A. R., Kirkham A. J., Cumming G. Assessment of smoking behaviour and ventilation with cigarettes of differing nicotine yields. Clin Sci (Lond) 1984 Dec;67(6):619–631. doi: 10.1042/cs0670619. [DOI] [PubMed] [Google Scholar]
- Russell M. A. Low-tar medium-nicotine cigarettes: a new approach to safer smoking. Br Med J. 1976 Jun 12;1(6023):1430–1433. doi: 10.1136/bmj.1.6023.1430. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Russell M. A., Sutton S. R., Iyer R., Feyerabend C., Vesey C. J. Long-term switching to low-tar low-nicotine cigarettes. Br J Addict. 1982 Jun;77(2):145–158. doi: 10.1111/j.1360-0443.1982.tb01416.x. [DOI] [PubMed] [Google Scholar]
- Russell M. A., Wilson C., Patel U. A., Cole P. V., Feyerabend C. Comparison of effect on tobacco consumption and carbon monoxide absorption of changing to high and low nicotine cigarettes. Br Med J. 1973 Dec 1;4(5891):512–516. doi: 10.1136/bmj.4.5891.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Russell M. A., Wilson C., Patel U. A., Feyerabend C., Cole P. V. Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields. Br Med J. 1975 May 24;2(5968):414–416. doi: 10.1136/bmj.2.5968.414. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sheahan N. F., Pavia D., Bateman J. R., Agnew J. E., Clarke S. W. A technique for monitoring the inhalation of cigarette smoke in man, using krypton-81m. Int J Appl Radiat Isot. 1980 Jul;31(7):438–441. doi: 10.1016/0020-708x(80)90084-8. [DOI] [PubMed] [Google Scholar]
- Sheahan N. F., Pavia D., Bateman J. R., Agnew J. E., Clarke S. W. Objective in vivo analysis of anti-smoking cigarette filters. Thorax. 1981 Mar;36(3):213–216. doi: 10.1136/thx.36.3.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sutton S. R., Feyerabend C., Cole P. V., Russell M. A. Adjustment of smokers to dilution of tobacco smoke by ventilated cigarette holders. Clin Pharmacol Ther. 1978 Oct;24(4):395–405. doi: 10.1002/cpt1978244395. [DOI] [PubMed] [Google Scholar]
- Sutton S. R., Russell M. A., Iyer R., Feyerabend C., Saloojee Y. Relationship between cigarette yields, puffing patterns, and smoke intake: evidence for tar compensation? 1982 Aug 28-Sep 4Br Med J (Clin Res Ed) 285(6342):600–603. doi: 10.1136/bmj.285.6342.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tobin M. J., Sackner M. A. Monitoring smoking patterns of low and high tar cigarettes with inductive plethysmography. Am Rev Respir Dis. 1982 Aug;126(2):258–264. doi: 10.1164/arrd.1982.126.2.258. [DOI] [PubMed] [Google Scholar]
- Wald N. J., Idle M., Boreham J., Bailey A. Inhaling habits among smokers of different types of cigarette. Thorax. 1980 Dec;35(12):925–928. doi: 10.1136/thx.35.12.925. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wald N., Howard S., Smith P. G., Kjeldsen K. Association between atherosclerotic diseases and carboxyhaemoglobin levels in tobacco smokers. Br Med J. 1973 Mar 31;1(5856):761–765. doi: 10.1136/bmj.1.5856.761. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodman G., Newman S. P., Pavia D., Clarke S. W. An in vivo radiotracer method to allow for cigarette filter ventilation during smoking. Clin Phys Physiol Meas. 1985 Nov;6(4):361–364. doi: 10.1088/0143-0815/6/4/009. [DOI] [PubMed] [Google Scholar]
- Woodman G., Newman S. P., Pavia D., Clarke S. W. Calibration and measurement of the inhaled smoke volume in cigarette smoking. Clin Phys Physiol Meas. 1985 Aug;6(3):251–255. doi: 10.1088/0143-0815/6/3/006. [DOI] [PubMed] [Google Scholar]
- Woodman G., Newman S. P., Pavia D., Clarke S. W. Inhaled smoke volume, puffing indices and carbon monoxide uptake in asymptomatic cigarette smokers. Clin Sci (Lond) 1986 Oct;71(4):421–427. doi: 10.1042/cs0710421. [DOI] [PubMed] [Google Scholar]
- Woodman G., Newman S. P., Pavia D., Clarke S. W. Temperature and calibration corrections to puff volume measurements in cigarette smoking. Phys Med Biol. 1984 Nov;29(11):1437–1440. doi: 10.1088/0031-9155/29/11/012. [DOI] [PubMed] [Google Scholar]
