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. 1987 Oct;42(10):784–789. doi: 10.1136/thx.42.10.784

Increased plasma motilin concentrations in small cell carcinoma of the lung.

A Noseda 1, T L Peeters 1, M Delhaye 1, V Bormans 1, Y Couvreur 1, G Vandermoten 1, P de Francquen 1, P Rocmans 1, J C Yernault 1
PMCID: PMC460952  PMID: 2892280

Abstract

Plasma samples from 21 patients with small cell carcinoma of the lung were screened for pancreatic polypeptide, somatostatin, motilin, and vasoactive intestinal polypeptide. One patient had severe impairment of both renal and liver function. In the 20 remaining subjects vasoactive intestinal polypeptide concentrations were normal, and only two patients had increased concentrations of somatostatin. Increases in pancreatic polypeptide were detected more commonly (7/20), but these may have been non-specific age related increases. The major finding was high concentrations of motilin (greater than 496 pg/ml) in 17 of 20 patients. Plasma motilin was subsequently assayed in 16 more patients with lung cancer, including 10 patients with non-small cell carcinoma of the lung. At concentrations over 900 pg/ml plasma motilin appears to be a tumour marker for small cell carcinoma of the lung with acceptable sensitivity (59%) and specificity (78%). The origin of increased plasma motilin in small cell carcinoma of the lung was investigated. Bombesin (gastrin releasing peptide), a peptide known to stimulate the release of motilin in man, was, as in previous studies, detected in tumour but not in plasma, except in one patient out of 21. Immunohistochemical studies failed to detect motilin antigen in biopsy samples. Motilin tumour content was found to be low in tumour tissue from three patients with small cell carcinoma of the lung who had appreciable hypermotilinaemia and from three patients with non-small cell carcinoma of the lung who had either normal or slightly raised plasma motilin concentrations. The stimulus to motilin secretion in patients with small cell carcinoma of the lung remains unclear.

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Selected References

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  1. Besterman H. S., Christofides N. D., Welsby P. D., Adrian T. E., Sarson D. L., Bloom S. R. Gut hormones in acute diarrhoea. Gut. 1983 Jul;24(7):665–671. doi: 10.1136/gut.24.7.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bryant M. G., Bloom S. R., Polak J. M., Hobbs S., Domschke W., Domschke S., Mitznegg P., Ruppin H., Demling L. Measurement of gut hormonal peptides in biopsies from human stomach and proximal small intestine. Gut. 1983 Feb;24(2):114–119. doi: 10.1136/gut.24.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carney D. N., Broder L., Edelstein M., Gazdar A. F., Hansen M., Havemann K., Matthews M. J., Sorenson G. D., Videløv L. Experimental studies of the biology of human small cell lung cancer. Cancer Treat Rep. 1983 Jan;67(1):27–35. [PubMed] [Google Scholar]
  4. Carney D. N., Marangos P. J., Ihde D. C., Bunn P. A., Jr, Cohen M. H., Minna J. D., Gazdar A. F. Serum neuron-specific enolase: a marker for disease extent and response to therapy of small-cell lung cancer. Lancet. 1982 Mar 13;1(8272):583–585. doi: 10.1016/s0140-6736(82)91748-2. [DOI] [PubMed] [Google Scholar]
  5. Esscher T., Steinholtz L., Bergh J., Nöu E., Nilsson K., Påhlman S. Neurone specific enolase: a useful diagnostic serum marker for small cell carcinoma of the lung. Thorax. 1985 Feb;40(2):85–90. doi: 10.1136/thx.40.2.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gazdar A. F., Carney D. N., Russell E. K., Sims H. L., Baylin S. B., Bunn P. A., Jr, Guccion J. G., Minna J. D. Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties. Cancer Res. 1980 Oct;40(10):3502–3507. [PubMed] [Google Scholar]
  7. Ghatei M. A., Jung R. T., Stevenson J. C., Hillyard C. J., Adrian T. E., Lee Y. C., Christofides N. D., Sarson D. L., Mashiter K., MacIntyre I. Bombesin: action on gut hormones and calcium in man. J Clin Endocrinol Metab. 1982 May;54(5):980–985. doi: 10.1210/jcem-54-5-980. [DOI] [PubMed] [Google Scholar]
  8. Ghose R. R., Gupta S. K. Oat cell carcinoma of bronchus presenting with somatostatinoma syndrome. Thorax. 1981 Jul;36(7):550–551. doi: 10.1136/thx.36.7.550. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Graham R. C., Jr, Karnovsky M. J. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J Histochem Cytochem. 1966 Apr;14(4):291–302. doi: 10.1177/14.4.291. [DOI] [PubMed] [Google Scholar]
  10. Janssens J., Hellemans J., Adrian T. E., Bloom S. R., Peeters T. L., Christofides N., Vantrappen G. R. Pancreatic polypeptide is not involved in the regulation of the migrating motor complex in man. Regul Pept. 1982 Jan;3(1):41–49. doi: 10.1016/0167-0115(82)90005-2. [DOI] [PubMed] [Google Scholar]
  11. Long R. G., Bryant M. G., Mitchell S. J., Adrian T. E., Polak J. M., Bloom S. R. Clinicopathological study of pancreatic and ganglioneuroblastoma tumours secreting vasoactive intestinal polypeptide (vipomas). Br Med J (Clin Res Ed) 1981 May 30;282(6278):1767–1771. doi: 10.1136/bmj.282.6278.1767. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McLeod R. S., Track N. S., Reynolds L. E. Elevated plasma motilin concentrations in chronic renal disease. Can Med Assoc J. 1979 Aug 4;121(3):268–273. [PMC free article] [PubMed] [Google Scholar]
  13. Peeters T. L., Vantrappen G., Janssens J. Fasting plasma motilin levels are related to the interdigestive motility complex. Gastroenterology. 1980 Oct;79(4):716–719. [PubMed] [Google Scholar]
  14. Penman E., Wass J. A., Besser G. M., Rees L. H. Somatostatin secretion by lung and thymic tumours. Clin Endocrinol (Oxf) 1980 Dec;13(6):613–620. doi: 10.1111/j.1365-2265.1980.tb03430.x. [DOI] [PubMed] [Google Scholar]
  15. Track N. S., Watters L. M., Gauldie J. Motilin, human pancreatic polypeptide (HPP) and gastrin plasma concentrations in fasting subjects. Clin Biochem. 1979 Aug;12(4):109–117. doi: 10.1016/s0009-9120(79)80135-6. [DOI] [PubMed] [Google Scholar]
  16. Vantrappen G., Janssens J., Peeters T. L., Bloom S. R., Christofides N. D., Hellemans J. Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci. 1979 Jul;24(7):497–500. doi: 10.1007/BF01489315. [DOI] [PubMed] [Google Scholar]
  17. Wharton J., Polak J. M., Bloom S. R., Ghatei M. A., Solcia E., Brown M. R., Pearse A. G. Bombesin-like immunoreactivity in the lung. Nature. 1978 Jun 29;273(5665):769–770. doi: 10.1038/273769a0. [DOI] [PubMed] [Google Scholar]
  18. Wood S. M., Wood J. R., Ghatei M. A., Lee Y. C., O'Shaughnessy D., Bloom S. R. Bombesin, somatostatin and neurotensin-like immunoreactivity in bronchial carcinoma. J Clin Endocrinol Metab. 1981 Dec;53(6):1310–1312. doi: 10.1210/jcem-53-6-1310. [DOI] [PubMed] [Google Scholar]
  19. Wood S. M., Wood J. R., Ghatei M. A., Sorenson G. D., Bloom S. Is bombesin a tumour marker for small-cell carcinoma? Lancet. 1982 Mar 20;1(8273):690–691. [PubMed] [Google Scholar]

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