Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1987 Oct;42(10):797–800. doi: 10.1136/thx.42.10.797

Effect of sustained release terbutaline on symptoms and sleep quality in patients with nocturnal asthma.

I C Stewart 1, G B Rhind 1, J T Power 1, D C Flenley 1, N J Douglas 1
PMCID: PMC460955  PMID: 3321540

Abstract

The effect of an oral sustained release beta 2 agonist on symptoms, sleep quality, and peak flow rates has been studied in nine patients with nocturnal asthma. Patients received oral terbutaline 7.5 mg twice daily or placebo for seven days in a double blind crossover study and spent the last two nights of each limb in a sleep laboratory. Oral terbutaline improved morning peak flow (259 v 213 l min-1) and decreased nocturnal inhaler usage (1.3 v 1.9) with no alteration in sleep quality as assessed electroencephalographically. The study shows that oral sustained release terbutaline can be useful in the treatment of nocturnal asthma without impairment of sleep quality.

Full text

PDF
797

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Catterall J. R., Douglas N. J., Calverley P. M., Brash H. M., Brezinova V., Shapiro C. M., Flenley D. C. Irregular breathing and hypoxaemia during sleep in chronic stable asthma. Lancet. 1982 Feb 6;1(8267):301–304. doi: 10.1016/s0140-6736(82)91567-7. [DOI] [PubMed] [Google Scholar]
  2. Douglas N. J. Asthma at night. Clin Chest Med. 1985 Dec;6(4):663–674. [PubMed] [Google Scholar]
  3. Douglas N. J., Brash H. M., Wraith P. K., Calverley P. M., Leggett R. J., McElderry L., Flenley D. C. Accuracy sensitivity to carboxyhemoglobin, and speed of response of the Hewlett-Packard 47201A ear oximeter. Am Rev Respir Dis. 1979 Feb;119(2):311–313. doi: 10.1164/arrd.1979.119.2.311. [DOI] [PubMed] [Google Scholar]
  4. Fairfax A. J., McNabb W. R., Davies H. J., Spiro S. G. Slow-release oral salbutamol and aminophylline in nocturnal asthma: relation of overnight changes in lung function and plasma drug levels. Thorax. 1980 Jul;35(7):526–530. doi: 10.1136/thx.35.7.526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Koëter G. H., Postma D. S., Keyzer J. J., Meurs H. Effect of oral slow-release terbutaline on early morning dyspnoea. Eur J Clin Pharmacol. 1985;28(2):159–162. doi: 10.1007/BF00609685. [DOI] [PubMed] [Google Scholar]
  6. Leferink J. G., Wagemaker-Engels I., Maes R. A. Quantitative analysis of terbutaline in serum and urine at therapeutic levels using gas chromatography--mass spectrometry. J Chromatogr. 1977 May 1;143(3):299–305. doi: 10.1016/s0378-4347(00)81810-1. [DOI] [PubMed] [Google Scholar]
  7. Montplaisir J., Walsh J., Malo J. L. Nocturnal asthma: features of attacks, sleep and breathing patterns. Am Rev Respir Dis. 1982 Jan;125(1):18–22. doi: 10.1164/arrd.1982.125.1.18. [DOI] [PubMed] [Google Scholar]
  8. Niederman M. S., Rafferty T. D., Sasaki C. T., Merrill W. W., Matthay R. A., Reynolds H. Y. Comparison of bacterial adherence to ciliated and squamous epithelial cells obtained from the human respiratory tract. Am Rev Respir Dis. 1983 Jan;127(1):85–90. doi: 10.1164/arrd.1983.127.1.85. [DOI] [PubMed] [Google Scholar]
  9. Rhind G. B., Connaughton J. J., McFie J., Douglas N. J., Flenley D. C. Sustained release choline theophyllinate in nocturnal asthma. Br Med J (Clin Res Ed) 1985 Dec 7;291(6509):1605–1607. doi: 10.1136/bmj.291.6509.1605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Turner-Warwick M. On observing patterns of airflow obstruction in chronic asthma. Br J Dis Chest. 1977 Apr;71(2):73–86. doi: 10.1016/0007-0971(77)90086-9. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES