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. 1987 Nov;42(11):863–869. doi: 10.1136/thx.42.11.863

Pattern of collagen types and molecular structure of collagen in acute post-traumatic pulmonary fibrosis.

A G Nerlich 1, M L Nerlich 1, P K Müller 1
PMCID: PMC461011  PMID: 3424268

Abstract

Analyses of collagen types and their amino acid structures have been made with lungs obtained from eight patients who died from the adult respiratory distress syndrome after non-pulmonary trauma. Collagen in lungs from patients with the adult respiratory distress syndrome was twice as soluble as that in control lungs (p less than 0.01). The proportion of type III collagen in the whole organ as well as in the pepsin solubilised fraction was slightly but significantly raised (net increase of about 5-10% type III collagen (p less than 0.05]. Both type I and type III collagen from the patients contained less hydroxylysine than collagen from control lungs. The alterations in tissue composition described here and observed in normal wound healing support the notion that acute post-traumatic pulmonary fibrosis resembles a wound healing process in the lungs.

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Selected References

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  1. Barnes M. J., Morton L. F., Bennett R. C., Bailey A. J., Sims T. J. Presence of type III collagen in guinea-pig dermal scar. Biochem J. 1976 Jul 1;157(1):263–266. doi: 10.1042/bj1570263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bateman E. D., Turner-Warwick M., Haslam P. L., Adelmann-Grill B. C. Cryptogenic fibrosing alveolitis: prediction of fibrogenic activity from immunohistochemical studies of collagen types in lung biopsy specimens. Thorax. 1983 Feb;38(2):93–101. doi: 10.1136/thx.38.2.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Clore J. N., Cohen I. K., Diegelmann R. F. Quantitation of collagen types I and III during wound healing in rat skin. Proc Soc Exp Biol Med. 1979 Jul;161(3):337–340. doi: 10.3181/00379727-161-40548. [DOI] [PubMed] [Google Scholar]
  4. Demling R. H., Nerlich M. Acute respiratory failure. Surg Clin North Am. 1983 Apr;63(2):337–355. doi: 10.1016/s0039-6109(16)42985-3. [DOI] [PubMed] [Google Scholar]
  5. Hering T. M., Marchant R. E., Anderson J. M. Type V collagen during granulation tissue development. Exp Mol Pathol. 1983 Oct;39(2):219–229. doi: 10.1016/0014-4800(83)90053-9. [DOI] [PubMed] [Google Scholar]
  6. Jukes T. H. Mutations in proteins and base changes in condons. Biochem Biophys Res Commun. 1975 Sep 2;66(1):1–8. doi: 10.1016/s0006-291x(75)80286-5. [DOI] [PubMed] [Google Scholar]
  7. Kirk J. M., Bateman E. D., Haslam P. L., Laurent G. J., Turner-Warwick M. Serum type III procollagen peptide concentration in cryptogenic fibrosing alveolitis and its clinical relevance. Thorax. 1984 Oct;39(10):726–732. doi: 10.1136/thx.39.10.726. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kirk J. M., Heard B. E., Kerr I., Turner-Warwick M., Laurent G. J. Quantitation of types I and III collagen in biopsy lung samples from patients with cryptogenic fibrosing alveolitis. Coll Relat Res. 1984 May;4(3):169–182. doi: 10.1016/s0174-173x(84)80039-4. [DOI] [PubMed] [Google Scholar]
  9. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. doi: 10.1038/227680a0. [DOI] [PubMed] [Google Scholar]
  10. Last J. A., Siefkin A. D., Reiser K. M. Type I collagen content is increased in lungs of patients with adult respiratory distress syndrome. Thorax. 1983 May;38(5):364–368. doi: 10.1136/thx.38.5.364. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Laurent G. J., Cockerill P., McAnulty R. J., Hastings J. R. A simplified method for quantitation of the relative amounts of type I and type III collagen in small tissue samples. Anal Biochem. 1981 May 15;113(2):301–312. doi: 10.1016/0003-2697(81)90081-6. [DOI] [PubMed] [Google Scholar]
  12. Laurent G. J. Lung collagen: more than scaffolding. Thorax. 1986 Jun;41(6):418–428. doi: 10.1136/thx.41.6.418. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mittermayer C., Hassenstein J., Riede U. N. Is shock-induced lung fibrosis reversible? A report on recovery from "shock-lung". Pathol Res Pract. 1978 May;162(1):73–87. doi: 10.1016/S0344-0338(78)80131-9. [DOI] [PubMed] [Google Scholar]
  14. Nerlich A. G., Nerlich M. L., Joachim H., Müller P. K. Biochemical changes in parenchymal lung tissue associated with posttraumatic respiratory failure. Eur J Clin Invest. 1984 Jun;14(3):190–198. doi: 10.1111/j.1365-2362.1984.tb01122.x. [DOI] [PubMed] [Google Scholar]
  15. Piez K. A. Molecular weight determination of random coil polypeptides from collagen by molecular sieve chromatography. Anal Biochem. 1968 Nov;26(2):305–312. doi: 10.1016/0003-2697(68)90342-4. [DOI] [PubMed] [Google Scholar]
  16. Porte A., Stoeckel M. E., Mantz J. M., Tempe J. D., Jaeger A., Batzenschlager A. Acute interstitial pulmonary fibrosis. Comparative light and electron microscopic study of 19 cases. Pathogenic and therapeutic implications. Intensive Care Med. 1978 Nov;4(4):181–191. doi: 10.1007/BF01902545. [DOI] [PubMed] [Google Scholar]
  17. Reiser K. M., Last J. A. Pulmonary fibrosis in experimental acute respiratory disease. Am Rev Respir Dis. 1981 Jan;123(1):58–63. doi: 10.1164/arrd.1981.123.1.58. [DOI] [PubMed] [Google Scholar]
  18. Riede U. N., Mittermayer C., Friedburg H., Wybitul K., Sandritter W. Morphologic development of human shock lung. Pathol Res Pract. 1979 Nov;165(3):269–286. doi: 10.1016/s0344-0338(79)80075-8. [DOI] [PubMed] [Google Scholar]
  19. Risteli J., Bächinger H. P., Engel J., Furthmayr H., Timpl R. 7-S collagen: characterization of an unusual basement membrane structure. Eur J Biochem. 1980;108(1):239–250. doi: 10.1111/j.1432-1033.1980.tb04717.x. [DOI] [PubMed] [Google Scholar]
  20. Seyer J. M., Hutcheson E. T., Kang A. H. Collagen polymorphism in idiopathic chronic pulmonary fibrosis. J Clin Invest. 1976 Jun;57(6):1498–1507. doi: 10.1172/JCI108420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Shoemaker C. T., Reiser K. M., Goetzman B. W., Last J. A. Elevated ratios of type I/III collagen in the lungs of chronically ventilated neonates with respiratory distress. Pediatr Res. 1984 Nov;18(11):1176–1180. doi: 10.1203/00006450-198411000-00025. [DOI] [PubMed] [Google Scholar]
  22. Takiya C., Peyrol S., Cordier J. F., Grimaud J. A. Connective matrix organization in human pulmonary fibrosis. Collagen polymorphism analysis in fibrotic deposits by immunohistological methods. Virchows Arch B Cell Pathol Incl Mol Pathol. 1983;44(2):223–240. doi: 10.1007/BF02890172. [DOI] [PubMed] [Google Scholar]
  23. Weber L., Kirsch E., Müller P., Krieg T. Collagen type distribution and macromolecular organization of connective tissue in different layers of human skin. J Invest Dermatol. 1984 Feb;82(2):156–160. doi: 10.1111/1523-1747.ep12259720. [DOI] [PubMed] [Google Scholar]
  24. Zapol W. M., Trelstad R. L., Coffey J. W., Tsai I., Salvador R. A. Pulmonary fibrosis in severe acute respiratory failure. Am Rev Respir Dis. 1979 Apr;119(4):547–554. doi: 10.1164/arrd.1979.119.4.547. [DOI] [PubMed] [Google Scholar]
  25. Zeitz M., Ruiz-Torres A., Merker H. J. Collagen metabolism in granulating wounds of rat skin. Arch Dermatol Res. 1978 Nov 10;263(2):207–214. doi: 10.1007/BF00446442. [DOI] [PubMed] [Google Scholar]

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